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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BICD2

Summary for BICD2

Gene information	Gene symbol	BICD2
	Ensembl ID	ENSG00000185963
	Entrez ID	23299
	Gene name	BICD cargo adaptor 2
	Synonyms	KIAA0699
	Gene type	protein_coding
	UniProtAcc	Q8TD16

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Dataset with differentially expressed gene: BICD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.283052	1.74e-05

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Expression of BICD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BICD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BICD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BICD2	hsa-miR-4795-3p	99.7626	NM_001003800
BICD2	hsa-miR-3140-5p	99.3866	NM_001003800
BICD2	hsa-miR-605-3p	98.694	NM_001003800
BICD2	hsa-miR-6749-3p	97.5224	NM_015250
BICD2	hsa-miR-527	97.2369	NM_001003800
BICD2	hsa-miR-518a-5p	97.2369	NM_001003800
BICD2	hsa-miR-126-5p	96.4897	NM_001003800
BICD2	hsa-miR-6507-5p	96.1626	NM_015250
BICD2	hsa-miR-6730-3p	95.6278	NM_001003800
BICD2	hsa-miR-6126	95.1205	NM_001003800
BICD2	hsa-miR-1253	94.9267	NM_001003800
BICD2	hsa-miR-210-5p	94.5399	NM_001003800
BICD2	hsa-miR-7152-5p	94.3466	NM_001003800
BICD2	hsa-miR-378a-5p	94.228	NM_001003800
BICD2	hsa-miR-101-3p	93.3937	NM_001003800
BICD2	hsa-miR-3074-5p	93.3834	NM_001003800
BICD2	hsa-miR-3667-3p	93.279	NM_015250
BICD2	hsa-miR-1200	93.2513	NM_001003800
BICD2	hsa-miR-942-3p	93.2371	NM_001003800
BICD2	hsa-miR-23a-3p	92.9073	NM_001003800
BICD2	hsa-miR-23b-3p	92.9073	NM_001003800
BICD2	hsa-miR-23c	92.9073	NM_001003800
BICD2	hsa-miR-548as-3p	92.8677	NM_001003800
BICD2	hsa-miR-3117-5p	92.5572	NM_001003800
BICD2	hsa-miR-338-5p	91.2103	NM_001003800
BICD2	hsa-miR-369-3p	91.0263	NM_015250
BICD2	hsa-miR-6719-3p	90.994	NM_001003800
BICD2	hsa-miR-450b-5p	90.6796	NM_015250
BICD2	hsa-miR-10393-5p	90.5598	NM_001003800
BICD2	hsa-miR-4330	90.1542	NM_001003800
BICD2	hsa-miR-624-5p	89.954	NM_001003800
BICD2	hsa-miR-4263	89.8338	NM_015250
BICD2	hsa-miR-6731-3p	88.9273	NM_001003800
BICD2	hsa-miR-570-5p	88.6876	NM_015250
BICD2	hsa-miR-548ba	88.6876	NM_015250
BICD2	hsa-miR-548ai	88.6876	NM_015250
BICD2	hsa-miR-548ag	88.6876	NM_015250
BICD2	hsa-miR-9-3p	88.5873	NM_001003800
BICD2	hsa-miR-452-5p	88.5466	NM_015250
BICD2	hsa-miR-656-3p	88.4483	NM_001003800
BICD2	hsa-miR-655-3p	88.352	NM_015250
BICD2	hsa-miR-374c-5p	88.352	NM_015250
BICD2	hsa-miR-4493	88.118	NM_001003800
BICD2	hsa-miR-12135	87.6234	NM_001003800
BICD2	hsa-miR-3167	87.4757	NM_015250
BICD2	hsa-miR-4659a-3p	87.2352	NM_015250
BICD2	hsa-miR-4659b-3p	87.2352	NM_015250
BICD2	hsa-miR-129-5p	86.9418	NM_001003800
BICD2	hsa-miR-3163	86.8351	NM_001003800
BICD2	hsa-miR-4793-3p	86.8084	NM_001003800

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Motifs and transcription factors (TFs) regulating BICD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."