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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: BHLHE41

Summary for BHLHE41

Gene information	Gene symbol	BHLHE41
	Ensembl ID	ENSG00000123095
	Entrez ID	79365
	Gene name	basic helix-loop-helix family member e41
	Synonyms	BHLHB3\|DEC2\|SHARP-1\|SHARP1
	Gene type	protein_coding
	UniProtAcc	Q9C0J9

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Dataset with differentially expressed gene: BHLHE41

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.78998	3.21e-05
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.477452	1.82e-14
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.277425	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.354087	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.400828	0.00e+00

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Expression of BHLHE41 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BHLHE41

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BHLHE41

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BHLHE41	hsa-miR-4325	96.4729	NM_030762
BHLHE41	hsa-miR-1304-5p	92.6872	NM_030762
BHLHE41	hsa-miR-6509-5p	91.2872	NM_030762
BHLHE41	hsa-miR-4429	88.8499	NM_030762
BHLHE41	hsa-miR-4732-3p	88.2277	NM_030762
BHLHE41	hsa-miR-3152-3p	88.0456	NM_030762
BHLHE41	hsa-miR-532-5p	88.0213	NM_030762
BHLHE41	hsa-miR-504-3p	87.5567	NM_030762
BHLHE41	hsa-miR-944	87.4398	NM_030762
BHLHE41	hsa-miR-548m	87.4152	NM_030762
BHLHE41	hsa-miR-526b-3p	87.0509	NM_030762
BHLHE41	hsa-miR-106b-5p	86.3311	NM_030762
BHLHE41	hsa-miR-20a-5p	86.3311	NM_030762
BHLHE41	hsa-miR-6749-3p	85.8524	NM_030762
BHLHE41	hsa-miR-1275	85.2795	NM_030762
BHLHE41	hsa-miR-4665-5p	85.2795	NM_030762
BHLHE41	hsa-miR-5590-3p	84.8615	NM_030762
BHLHE41	hsa-miR-142-5p	84.8615	NM_030762
BHLHE41	hsa-miR-320c	84.8126	NM_030762
BHLHE41	hsa-miR-320a-3p	84.8126	NM_030762
BHLHE41	hsa-miR-320d	84.8126	NM_030762
BHLHE41	hsa-miR-320b	84.8126	NM_030762
BHLHE41	hsa-miR-519d-3p	84.3094	NM_030762
BHLHE41	hsa-miR-17-5p	84.3094	NM_030762
BHLHE41	hsa-miR-20b-5p	84.3094	NM_030762
BHLHE41	hsa-miR-93-5p	84.3094	NM_030762
BHLHE41	hsa-miR-106a-5p	84.3094	NM_030762
BHLHE41	hsa-miR-301b-3p	83.4882	NM_030762
BHLHE41	hsa-miR-4295	83.4882	NM_030762
BHLHE41	hsa-miR-130b-3p	83.4882	NM_030762
BHLHE41	hsa-miR-301a-3p	83.4882	NM_030762
BHLHE41	hsa-miR-130a-3p	83.4882	NM_030762
BHLHE41	hsa-miR-3666	83.4882	NM_030762
BHLHE41	hsa-miR-454-3p	83.4882	NM_030762
BHLHE41	hsa-miR-5009-5p	82.8149	NM_030762
BHLHE41	hsa-miR-146a-5p	82.3262	NM_030762
BHLHE41	hsa-miR-146b-5p	82.3262	NM_030762
BHLHE41	hsa-miR-7153-5p	82.3262	NM_030762
BHLHE41	hsa-miR-888-5p	81.2752	NM_030762
BHLHE41	hsa-miR-8058	80.2267	NM_030762

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Motifs and transcription factors (TFs) regulating BHLHE41

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BHLHE41	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
BHLHE41	transfac_pro__M07387	ZBTB7A (directAnnotation).
BHLHE41	transfac_pro__M07436	WT1 (directAnnotation).
BHLHE41	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
BHLHE41	transfac_pro__M00716	ZBTB14 (directAnnotation).
BHLHE41	swissregulon__hs__CHD1	CHD1 (directAnnotation).
BHLHE41	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
BHLHE41	transfac_pro__M04893	TAF1 (directAnnotation).
BHLHE41	transfac_pro__M03876	ZBTB33 (directAnnotation).
BHLHE41	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
BHLHE41	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BHLHE41	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
BHLHE41	transfac_pro__M06660	ZNF670 (directAnnotation).
BHLHE41	swissregulon__mm__Nkx2-3	NKX2-3 (inferredBy_Orthology).
BHLHE41	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
BHLHE41	transfac_pro__M04722	SPI1 (directAnnotation).
BHLHE41	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
BHLHE41	transfac_pro__M07399	NKX6-1 (directAnnotation).
BHLHE41	transfac_pro__M01425	HNF1B (directAnnotation).
BHLHE41	tfdimers__MD00145	ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).
BHLHE41	transfac_public__M00039	CREB1 (directAnnotation).
BHLHE41	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
BHLHE41	transfac_pro__M07329	SP7 (directAnnotation).
BHLHE41	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
BHLHE41	metacluster_3.14	WT1; WT1 (directAnnotation).
BHLHE41	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
BHLHE41	transfac_pro__M01837	KLF11 (directAnnotation).
BHLHE41	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
BHLHE41	transfac_pro__M07310	SP5 (directAnnotation).
BHLHE41	swissregulon__hs__KLF6	KLF6 (directAnnotation).
BHLHE41	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
BHLHE41	cisbp__M00968	MTF2 (directAnnotation).
BHLHE41	transfac_pro__M04916	TAF1 (directAnnotation).
BHLHE41	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
BHLHE41	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
BHLHE41	transfac_pro__M01303	SP1 (directAnnotation).
BHLHE41	dbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1	ZFP91 (directAnnotation).
BHLHE41	swissregulon__hs__SOX1	SOX1 (directAnnotation).
BHLHE41	jaspar__MA1633.2	BACH1 (directAnnotation).
BHLHE41	tfdimers__MD00097	GABPA; PAX4 (directAnnotation).
BHLHE41	transfac_pro__M06353	ZNF782 (directAnnotation).
BHLHE41	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
BHLHE41	transfac_pro__M06257	ZNF616 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
BHLHE41	metacluster_14.6	up	Malignant cells	GSE161801_IMiD	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."