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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor

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Acts as a drug target< (This gene does not contain this module)

Gene: BHLHE40

Summary for BHLHE40

Gene informationGene symbol

BHLHE40

Ensembl ID

ENSG00000134107

Entrez ID

8553

Gene namebasic helix-loop-helix family member e40
SynonymsBHLHB2|Clast5|DEC1|SHARP2|STRA13
Gene typeprotein_coding
UniProtAcc

O14503


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Dataset with differentially expressed gene: BHLHE40

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE131984_Pac

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)ChemotherapypaclitaxelNAMalignant cells-0.4742343.82e-22

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostcDCs0.394937.22e-07

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostpDCs0.937211.11e-05

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells0.348551.06e-11

GSE153697

patientsBone marrow aspirateAcute lymphoblastic leukemiaRelapsed B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyanti-CD19 CAR-TNAMalignant cells-0.271275.18e-04

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostCD4+ T cells0.2649760.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostB cells0.2954964.31e-22

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostNK cells-0.3420314.66e-04

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD8+ T cells0.3068310.00e+00

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAMono/Macro-0.7087560.00e+00

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD8+ T cells-0.6914850.00e+00

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD4+ T cells-0.8576380.00e+00

GSE212217

patientsPeripheral blood mononuclear cellsEndometrial cancerEpigenetic MMRd endometrial carcinomaImmunotherapypembrolizumabprecDCs0.2503931.38e-05

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postNeutrophils0.5763484.70e-17

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD8+ T cells0.6057872.55e-33

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)postMono/Macro-0.2641490.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preNK cells0.3076954.05e-24

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMono/Macro0.3636742.77e-03

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMalignant cells0.5823862.07e-24

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postB cells-0.6797342.15e-04

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postNeutrophils0.517383.09e-08

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMono/Macro-0.4738920.00e+00

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreCD8+ T cells-0.2665346.64e-16

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreNK cells-0.4181531.35e-10

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreCD8+ T cells0.4048890.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostcDCs-0.3121141.21e-16

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells-0.6387560.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells-0.6558250.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreNK cells0.5057296.86e-08

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreMalignant cells-0.4370980.00e+00

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells0.3988823.84e-20

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells-0.3238320.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasoneprecDCs-0.4235751.89e-03

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Expression of BHLHE40 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to BHLHE40

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BHLHE40

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
BHLHE40hsa-miR-1277-5p99.1676NM_003670
BHLHE40hsa-miR-548an99.0536NM_003670
BHLHE40hsa-miR-612498.5297NM_003670
BHLHE40hsa-miR-848598.2314NM_003670
BHLHE40hsa-miR-6515-3p98.024NM_003670
BHLHE40hsa-miR-1236-3p97.9104NM_003670
BHLHE40hsa-miR-4753-3p97.13NM_003670
BHLHE40hsa-miR-584-3p96.2573NM_003670
BHLHE40hsa-miR-446595.2107NM_003670
BHLHE40hsa-miR-26b-5p95.2107NM_003670
BHLHE40hsa-miR-26a-5p95.2107NM_003670
BHLHE40hsa-miR-1245b-5p95.19NM_003670
BHLHE40hsa-miR-129795.0767NM_003670
BHLHE40hsa-miR-5011-5p94.5106NM_003670
BHLHE40hsa-miR-57794.4433NM_003670
BHLHE40hsa-miR-426293.4809NM_003670
BHLHE40hsa-miR-181b-5p93.4809NM_003670
BHLHE40hsa-miR-181c-5p93.4809NM_003670
BHLHE40hsa-miR-181a-5p93.4809NM_003670
BHLHE40hsa-miR-181d-5p93.4809NM_003670
BHLHE40hsa-miR-5692b93.3767NM_003670
BHLHE40hsa-miR-5692c93.3767NM_003670
BHLHE40hsa-let-7f-1-3p92.9449NM_003670
BHLHE40hsa-miR-98-3p92.9449NM_003670
BHLHE40hsa-let-7b-3p92.9449NM_003670
BHLHE40hsa-let-7a-3p92.9449NM_003670
BHLHE40hsa-miR-314292.5914NM_003670
BHLHE40hsa-miR-942-5p91.9957NM_003670
BHLHE40hsa-miR-448489.2266NM_003670
BHLHE40hsa-miR-6768-3p89.2266NM_003670
BHLHE40hsa-miR-94488.4456NM_003670
BHLHE40hsa-miR-524-5p87.3398NM_003670
BHLHE40hsa-miR-520d-5p87.3398NM_003670
BHLHE40hsa-miR-4477a87.1671NM_003670
BHLHE40hsa-miR-6766-5p86.6751NM_003670
BHLHE40hsa-miR-615-5p86.6694NM_003670
BHLHE40hsa-miR-127-5p86.5969NM_003670
BHLHE40hsa-miR-190a-3p86.2651NM_003670
BHLHE40hsa-miR-429385.9618NM_003670
BHLHE40hsa-miR-4789-5p85.0992NM_003670
BHLHE40hsa-miR-518c-5p83.8192NM_003670
BHLHE40hsa-miR-302c-5p83.7886NM_003670
BHLHE40hsa-miR-314383.3905NM_003670
BHLHE40hsa-miR-6800-3p83.3373NM_003670
BHLHE40hsa-miR-445383.2306NM_003670
BHLHE40hsa-miR-453883.2306NM_003670
BHLHE40hsa-miR-6809-3p82.8763NM_003670
BHLHE40hsa-miR-100-3p82.7672NM_003670
BHLHE40hsa-miR-651-5p82.3183NM_003670
BHLHE40hsa-miR-1185-1-3p81.3949NM_003670
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Motifs and transcription factors (TFs) regulating BHLHE40

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
BHLHE40metacluster_170.2KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
BHLHE40jaspar__MA0079.5SP1 (directAnnotation).
BHLHE40kznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
BHLHE40kznf__ZNF548_Imbeault2017_RP_RCADEZNF548 (directAnnotation).
BHLHE40metacluster_172.6CHD2; E2F1 (directAnnotation).
BHLHE40transfac_pro__M06783ZNF443 (directAnnotation).
BHLHE40homer__ATTGCGCAAC_CEBPCEBPB (inferredBy_Orthology).
BHLHE40transfac_pro__M06763ZNF225 (directAnnotation).
BHLHE40tfdimers__MD00152HOXA13; NKX6-2 (directAnnotation).
BHLHE40transfac_pro__M02015FOXA3 (directAnnotation).
BHLHE40taipale_tf_pairs__HOXB2_RFX5_TAATKRNNNNGCAAC_CAP_reprHOXB2; RFX5 (directAnnotation).
BHLHE40tfdimers__MD00115E2F1; NR1I2; RXRA (directAnnotation).
BHLHE40jaspar__MA1561.1SOX12 (directAnnotation).
BHLHE40taipale_tf_pairs__HOXD12_ETV4_RSCGGAAGTCGTAAAN_CAPETV4; HOXD12 (directAnnotation).
BHLHE40dbtfbs__E4F1_K562_ENCSR731LHZ_merged_N1E4F1 (directAnnotation).
BHLHE40taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAPETV4; GCM1 (directAnnotation).
BHLHE40taipale_tf_pairs__HOXD12_TBX21_AGGTGTKAAGTCGTAAA_CAP_reprHOXD12; TBX21 (directAnnotation).
BHLHE40metacluster_77.20SOX1 (inferredBy_Orthology).
BHLHE40metacluster_77.14SOX7 (inferredBy_Orthology).
BHLHE40transfac_pro__M05538ZNF536 (inferredBy_Orthology).
BHLHE40transfac_pro__M07431SOX11 (directAnnotation).
BHLHE40taipale_tf_pairs__HOXB2_SOX15_NYMATTANNNNNNACAATR_CAP_reprHOXB2; SOX15 (directAnnotation).
BHLHE40metacluster_82.5ZKSCAN8; ZNF205; ZNF227; ZNF594 (directAnnotation).
BHLHE40metacluster_153.2HBP1; SOX1; SOX10; SOX11; SOX13; SOX13; SOX13; SOX15; SOX15; SOX15; SOX15; SOX17; SOX17; SOX18; SOX2; SOX2; SOX2; SOX2; SOX21; SOX3; SOX30; SOX4; SOX5; SOX5; SOX5; SOX6; SOX6; SOX6; SOX7; SOX8; SOX9; SRY; SRY (directAnnotation). SOX17; SOX2 (inferredBy_Orthology).
BHLHE40transfac_pro__M02869HOXA3 (inferredBy_Orthology).
BHLHE40metacluster_77.10SRY (inferredBy_Orthology).
BHLHE40kznf__ZNF384_Schmitges2016_RCADEZNF384 (directAnnotation).
BHLHE40metacluster_130.3ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
BHLHE40metacluster_157.2ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
BHLHE40jaspar__MA1125.1ZNF384 (directAnnotation).
BHLHE40kznf__CTCF_Rhee2011.2_ChIP-exoCTCF (directAnnotation).
BHLHE40metacluster_32.24ZNF287 (directAnnotation).
BHLHE40metacluster_137.2ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
BHLHE40kznf__ZNF613_Imbeault2017_RP_RCADEZNF613 (directAnnotation).
BHLHE40transfac_pro__M06569ZNF775 (directAnnotation).
BHLHE40transfac_pro__M01969FOXO1 (directAnnotation).
BHLHE40transfac_pro__M05759ZNF544 (directAnnotation).
BHLHE40taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_reprCEBPB; GCM1 (directAnnotation).
BHLHE40transfac_pro__M06249ZNF616 (directAnnotation).
BHLHE40taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYA_CAP_reprELK1; FOXI1 (directAnnotation).
BHLHE40transfac_pro__M06742ZNF304 (directAnnotation).
BHLHE40transfac_pro__M05927ZNF408 (directAnnotation).
BHLHE40transfac_pro__M02080ISL2 (directAnnotation).
BHLHE40transfac_pro__M06462ZNF441 (directAnnotation).
BHLHE40cisbp__M00212SOX13 (inferredBy_Orthology).
BHLHE40metacluster_144.8ZNF30; ZNF30 (directAnnotation).
BHLHE40swissregulon__hs__CHD1CHD1 (directAnnotation).
BHLHE40kznf__ZNF90_Imbeault2017_OM_RCADEZNF90 (directAnnotation).
BHLHE40taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_methZNF460 (directAnnotation).
BHLHE40transfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.
TFmotifExpressionCell typeDatasetTimepoint
BHLHE40metacluster_57.3downMalignant cells

GSE131984_Pac

NA
BHLHE40metacluster_14.17downNK cells

GSE169246_PacAteTissue

post
BHLHE40metacluster_14.2downNK cells

GSE169246_PacAteTissue

post
BHLHE40metacluster_14.4downNK cells

GSE169246_PacAteTissue

post
BHLHE40metacluster_57.3upNeutrophils

GSE207422_Sin

post
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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."