Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BEX2

Summary for BEX2

Gene information	Gene symbol	BEX2
	Ensembl ID	ENSG00000133134
	Entrez ID	84707
	Gene name	brain expressed X-linked 2
	Synonyms	DJ79P11.1
	Gene type	protein_coding
	UniProtAcc	Q9BXY8

Top

Dataset with differentially expressed gene: BEX2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.93341	3.02e-15
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.790028	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.369921	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.558954	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.48136	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.520501	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.32527	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.458603	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.26408	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.596171	0.00e+00

Top

Expression of BEX2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to BEX2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating BEX2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BEX2	hsa-miR-5581-3p	94.1112	NM_001168399
BEX2	hsa-miR-548ar-3p	90.954	NM_001168399
BEX2	hsa-miR-548az-3p	88.2615	NM_001168399
BEX2	hsa-miR-548bc	88.2615	NM_001168399
BEX2	hsa-miR-548f-3p	88.2615	NM_001168399
BEX2	hsa-miR-548a-3p	88.2615	NM_001168399
BEX2	hsa-miR-548e-3p	88.2615	NM_001168399
BEX2	hsa-miR-133a-5p	86.6183	NM_001168399
BEX2	hsa-miR-6872-3p	85.362	NM_001168399

Page: 1

Top

Motifs and transcription factors (TFs) regulating BEX2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BEX2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
BEX2	metacluster_3.14	WT1; WT1 (directAnnotation).
BEX2	transfac_pro__M06827	ZBTB11 (directAnnotation).
BEX2	jaspar__MA1934.1	FIGLA (directAnnotation).
BEX2	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
BEX2	transfac_pro__M04617	ZBTB7A (directAnnotation).
BEX2	transfac_pro__M07436	WT1 (directAnnotation).
BEX2	hdpi__HIP2	UBE2K (directAnnotation).
BEX2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
BEX2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
BEX2	transfac_pro__M04893	TAF1 (directAnnotation).
BEX2	transfac_pro__M03876	ZBTB33 (directAnnotation).
BEX2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BEX2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
BEX2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BEX2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
BEX2	tfdimers__MD00339	HMGA1; HMGA2; TFAP2C (directAnnotation).
BEX2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
BEX2	transfac_pro__M06554	ZNF483 (directAnnotation).
BEX2	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
BEX2	jaspar__MA0502.2	NFYB (directAnnotation).
BEX2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
BEX2	metacluster_7.13	ZFX (directAnnotation).
BEX2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
BEX2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
BEX2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
BEX2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BEX2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
BEX2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
BEX2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BEX2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
BEX2	transfac_pro__M00938	E2F1 (directAnnotation).
BEX2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
BEX2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
BEX2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
BEX2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
BEX2	swissregulon__hs__KLF6	KLF6 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."