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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BEND6

Summary for BEND6

Gene information	Gene symbol	BEND6
	Ensembl ID	ENSG00000151917
	Entrez ID	221336
	Gene name	BEN domain containing 6
	Synonyms	bA203B9.1\|C6orf65\|FLJ30162
	Gene type	protein_coding
	UniProtAcc	Q5SZJ8

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Dataset with differentially expressed gene: BEND6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.270114	9.19e-18
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.799188	0.00e+00

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Expression of BEND6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BEND6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BEND6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BEND6	hsa-miR-153-5p	96.8727	NM_001318539
BEND6	hsa-miR-4705	93.459	NM_152731
BEND6	hsa-miR-3674	92.2433	NM_001318539
BEND6	hsa-miR-1587	90.7663	NM_152731
BEND6	hsa-miR-4804-3p	90.6702	NM_152731
BEND6	hsa-miR-4775	90.6242	NM_001318539
BEND6	hsa-miR-6867-5p	89.7451	NM_152731
BEND6	hsa-miR-1236-3p	89.4008	NM_001318539
BEND6	hsa-miR-3143	89.316	NM_152731
BEND6	hsa-miR-1825	89.1865	NM_152731
BEND6	hsa-miR-4656	88.9709	NM_152731
BEND6	hsa-miR-204-5p	88.9037	NM_001318539
BEND6	hsa-miR-211-5p	88.9037	NM_001318539
BEND6	hsa-miR-3620-5p	88.5558	NM_152731
BEND6	hsa-miR-7112-3p	87.3599	NM_152731
BEND6	hsa-miR-4490	87.2336	NM_152731
BEND6	hsa-miR-466	86.9151	NM_152731
BEND6	hsa-miR-3200-5p	86.2276	NM_001318539
BEND6	hsa-miR-5100	86.1237	NM_001318539
BEND6	hsa-miR-3191-5p	85.9122	NM_152731
BEND6	hsa-miR-7156-5p	85.6447	NM_152731
BEND6	hsa-miR-4742-3p	85.6253	NM_152731
BEND6	hsa-miR-1288-5p	85.495	NM_001318539
BEND6	hsa-miR-627-3p	84.5426	NM_001318539
BEND6	hsa-miR-6762-3p	84.4068	NM_152731
BEND6	hsa-miR-345-3p	84.1631	NM_152731
BEND6	hsa-miR-4273	84.0887	NM_152731
BEND6	hsa-miR-10226	83.6509	NM_152731
BEND6	hsa-miR-670-5p	81.8382	NM_152731
BEND6	hsa-miR-6501-5p	81.2195	NM_001318539
BEND6	hsa-miR-4254	80.7663	NM_001318539
BEND6	hsa-miR-500a-3p	80.766	NM_001318539
BEND6	hsa-miR-3149	80.2977	NM_001318539
BEND6	hsa-miR-4307	80.2396	NM_152731
BEND6	hsa-miR-4696	80.234	NM_001318539
BEND6	hsa-miR-335-3p	80.0513	NM_001318539

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Motifs and transcription factors (TFs) regulating BEND6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BEND6	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
BEND6	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
BEND6	transfac_pro__M04950	EGR1 (directAnnotation).
BEND6	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
BEND6	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
BEND6	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
BEND6	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
BEND6	transfac_pro__M00652	NRF1 (directAnnotation).
BEND6	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
BEND6	transfac_pro__M04866	HDAC2 (directAnnotation).
BEND6	jaspar__MA1122.1	TFDP1 (directAnnotation).
BEND6	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
BEND6	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
BEND6	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
BEND6	metacluster_7.13	ZFX (directAnnotation).
BEND6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BEND6	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
BEND6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
BEND6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BEND6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
BEND6	cisbp__M00249	WT1 (directAnnotation).
BEND6	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
BEND6	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
BEND6	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
BEND6	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."