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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: BCLAF1

Summary for BCLAF1

Gene information	Gene symbol	BCLAF1
	Ensembl ID	ENSG00000029363
	Entrez ID	9774
	Gene name	BCL2 associated transcription factor 1
	Synonyms	BTF\|KIAA0164
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: BCLAF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.282465	3.61e-42
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.326375	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.336616	6.29e-10
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.336864	1.24e-11
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.484938	1.42e-19
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.304396	2.78e-26
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.313147	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.31676	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.679363	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.677958	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.881002	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.667893	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.658981	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.542177	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.818155	3.10e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.265973	8.12e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.307552	0.00e+00

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Expression of BCLAF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BCLAF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BCLAF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BCLAF1	hsa-miR-510-3p	98.5803	NM_001077440
BCLAF1	hsa-miR-4282	98.3931	NM_001077440
BCLAF1	hsa-miR-1305	95.8792	NM_001077440
BCLAF1	hsa-miR-513c-5p	94.6719	NM_001077440
BCLAF1	hsa-miR-514b-5p	94.6719	NM_001077440
BCLAF1	hsa-miR-4262	94.6524	NM_001077440
BCLAF1	hsa-miR-222-5p	94.1651	NM_001077440
BCLAF1	hsa-miR-7-1-3p	92.8037	NM_001077440
BCLAF1	hsa-miR-7-2-3p	92.8037	NM_001077440
BCLAF1	hsa-miR-499b-3p	92.7779	NM_001077440
BCLAF1	hsa-miR-499a-3p	92.7779	NM_001077440
BCLAF1	hsa-miR-545-5p	92.7278	NM_001077440
BCLAF1	hsa-miR-181d-5p	91.8766	NM_001077440
BCLAF1	hsa-miR-181c-5p	91.8766	NM_001077440
BCLAF1	hsa-miR-181a-5p	91.8766	NM_001077440
BCLAF1	hsa-miR-181b-5p	91.8766	NM_001077440
BCLAF1	hsa-miR-570-3p	91.807	NM_001077440
BCLAF1	hsa-miR-582-5p	91.5721	NM_001077440
BCLAF1	hsa-miR-4482-3p	90.9445	NM_001077440
BCLAF1	hsa-miR-5692a	90.6446	NM_001077440
BCLAF1	hsa-miR-659-3p	89.4507	NM_001077440
BCLAF1	hsa-miR-224-5p	88.6442	NM_001077440
BCLAF1	hsa-miR-4267	87.4703	NM_001077440
BCLAF1	hsa-miR-6516-5p	86.7033	NM_001077440
BCLAF1	hsa-miR-4717-5p	86.2588	NM_001077440
BCLAF1	hsa-miR-524-5p	85.8423	NM_001077440
BCLAF1	hsa-miR-520d-5p	85.8423	NM_001077440
BCLAF1	hsa-miR-153-5p	85.3095	NM_001077440
BCLAF1	hsa-miR-205-3p	85.1111	NM_001077440
BCLAF1	hsa-miR-6780a-3p	84.7675	NM_001077440
BCLAF1	hsa-miR-6833-3p	84.7176	NM_001077440
BCLAF1	hsa-miR-6828-3p	83.9739	NM_001077440
BCLAF1	hsa-miR-591	83.5597	NM_001077440
BCLAF1	hsa-miR-7111-3p	83.5406	NM_001077440
BCLAF1	hsa-miR-4719	82.4692	NM_001077440
BCLAF1	hsa-miR-5688	82.3549	NM_001077440
BCLAF1	hsa-miR-4768-5p	81.7017	NM_001077440
BCLAF1	hsa-miR-3148	81.3959	NM_001077440
BCLAF1	hsa-miR-5582-3p	81.3165	NM_001077440
BCLAF1	hsa-miR-4504	81.2277	NM_001077440
BCLAF1	hsa-miR-1323	80.5376	NM_001077440
BCLAF1	hsa-miR-548ar-3p	80.416	NM_001077440
BCLAF1	hsa-miR-625-5p	80.0818	NM_001077440

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Motifs and transcription factors (TFs) regulating BCLAF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BCLAF1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
BCLAF1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
BCLAF1	transfac_pro__M01783	SP2 (directAnnotation).
BCLAF1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
BCLAF1	cisbp__M00341	PAX6 (directAnnotation).
BCLAF1	transfac_pro__M01253	CNOT3 (directAnnotation).
BCLAF1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
BCLAF1	metacluster_7.13	ZFX (directAnnotation).
BCLAF1	cisbp__M00968	MTF2 (directAnnotation).
BCLAF1	transfac_pro__M04817	ZBTB33 (directAnnotation).
BCLAF1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
BCLAF1	transfac_pro__M02089	E2F3 (directAnnotation).
BCLAF1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
BCLAF1	jaspar__MA0748.2	YY2 (directAnnotation).
BCLAF1	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
BCLAF1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
BCLAF1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
BCLAF1	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
BCLAF1	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
BCLAF1	transfac_pro__M00652	NRF1 (directAnnotation).
BCLAF1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
BCLAF1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
BCLAF1	hdpi__EBF1	EBF1 (directAnnotation).
BCLAF1	metacluster_101.3	MYB (directAnnotation).
BCLAF1	hdpi__TP73	TP73 (directAnnotation).
BCLAF1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
BCLAF1	transfac_pro__M04950	EGR1 (directAnnotation).
BCLAF1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
BCLAF1	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
BCLAF1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
BCLAF1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
BCLAF1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
BCLAF1	cisbp__M02645	ETS1 (directAnnotation).
BCLAF1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
BCLAF1	hdpi__TIMELESS	TIMELESS (directAnnotation).
BCLAF1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
BCLAF1	transfac_pro__M05893	ZNF676 (directAnnotation).
BCLAF1	hdpi__ETV4	ETV4 (directAnnotation).
BCLAF1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
BCLAF1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
BCLAF1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
BCLAF1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
BCLAF1	hdpi__FLI1	FLI1 (directAnnotation).
BCLAF1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
BCLAF1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
BCLAF1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BCLAF1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
BCLAF1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
BCLAF1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
BCLAF1	cisbp__M00788	ZFY (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
BCLAF1	metacluster_166.4	down	Malignant cells	GSE153697	NA
BCLAF1	metacluster_166.4	up	CD4+ T cells	GSE169246_PacBlood	pre
BCLAF1	metacluster_166.4	up	B cells	GSE169246_PacTissue	pre
BCLAF1	metacluster_166.4	down	CD4+ T cells	GSE199333	post
BCLAF1	metacluster_166.4	down	Malignant cells	GSE199333	post
BCLAF1	metacluster_166.4	down	NK cells	GSE199333	post
BCLAF1	metacluster_166.4	down	B cells	GSE199333	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."