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| Expression of this gene in the resistant group across all datasets and cell types |
| Significant ligand-receptor pairs related to this gene (This gene does not contain this module) |
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| Acts as a transcription factor (This gene does not contain this module) |
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Gene: BCL2 |
Summary for BCL2 |
| Gene information | Gene symbol | BCL2 | Ensembl ID | ENSG00000171791 |
| Entrez ID | 596 | |
| Gene name | BCL2 apoptosis regulator | |
| Synonyms | Bcl-2|PPP1R50 | |
| Gene type | protein_coding | |
| UniProtAcc | NA |
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Dataset with differentially expressed gene: BCL2 |
 Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group. |
| Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | B cells | 0.384535 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | CD4+ T cells | 0.41065 | 0.00e+00 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | B cells | 0.491185 | 7.84e-36 |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | pre | CD4+ T cells | 0.310776 | 1.35e-22 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD4+ T cells | 0.57173 | 0.00e+00 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD8+ T cells | 0.324626 | 0.00e+00 |
GSE197268_Tisa-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | tisa-cel (CAR-T) | pre | CD4+ T cells | 0.300521 | 3.34e-38 |
GSE189460 | patients | Bone marrow aspirate | Multiple myeloma | Multiple myeloma (MM) | Targeted therapy | bortezomib + melphalan + prednisolone | pre | Malignant cells | 0.528497 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD8+ T cells | 0.283166 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD4+ T cells | 0.689053 | 0.00e+00 |
GSE152469 | patients | Peripheral blood mononuclear cells | Chronic lymphocytic leukemia | Chronic lymphocytic leukemia (CLL) | Targeted therapy | ibrutinib | NA | Malignant cells | 0.631405 | 0.00e+00 |
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Expression of BCL2 in the resistant group across all datasets and cell types |
| Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.) |
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Significant ligand-receptor pairs related to BCL2 |
| This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.) |
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Known drug resistance mechanisms of this gene |
| This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information. |
| Gene symbol | Mechanism |
BCL2 | Aberration of the Drug's Therapeutic Target |
BCL2 | Epigenetic Alteration of DNA, RNA or Protein |
BCL2 | Regulation by the Disease Microenvironment |
BCL2 | Unusual Activation of Pro-survival Pathway |
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MicroRNAs (miRNA) regulating BCL2 |
| This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.) |
| Gene symbol | miRNA | Score | GeneBank accession |
| BCL2 | hsa-miR-6867-5p | 99.9932 | NM_000633 |
| BCL2 | hsa-miR-4495 | 99.0025 | NM_000633 |
| BCL2 | hsa-miR-448 | 98.5909 | NM_000633 |
| BCL2 | hsa-miR-4708-5p | 97.7701 | NM_000633 |
| BCL2 | hsa-miR-5692a | 97.6528 | NM_000633 |
| BCL2 | hsa-miR-3680-3p | 96.0238 | NM_000633 |
| BCL2 | hsa-miR-646 | 93.7183 | NM_000633 |
| BCL2 | hsa-miR-4262 | 93.0764 | NM_000633 |
| BCL2 | hsa-miR-202-5p | 92.8723 | NM_000633 |
| BCL2 | hsa-miR-486-3p | 92.784 | NM_000633 |
| BCL2 | hsa-miR-1178-3p | 91.0622 | NM_000633 |
| BCL2 | hsa-miR-181c-5p | 90.1581 | NM_000633 |
| BCL2 | hsa-miR-181a-5p | 90.1581 | NM_000633 |
| BCL2 | hsa-miR-181d-5p | 90.1581 | NM_000633 |
| BCL2 | hsa-miR-181b-5p | 90.1581 | NM_000633 |
| BCL2 | hsa-miR-522-3p | 90.0482 | NM_000633 |
| BCL2 | hsa-miR-224-3p | 90.0482 | NM_000633 |
| BCL2 | hsa-miR-1237-3p | 89.9685 | NM_000633 |
| BCL2 | hsa-miR-4260 | 89.1838 | NM_000633 |
| BCL2 | hsa-miR-450b-5p | 89.1616 | NM_000633 |
| BCL2 | hsa-miR-6776-3p | 88.8882 | NM_000633 |
| BCL2 | hsa-miR-507 | 86.8573 | NM_000633 |
| BCL2 | hsa-miR-1276 | 86.3422 | NM_000633 |
| BCL2 | hsa-miR-3177-5p | 86.1543 | NM_000633 |
| BCL2 | hsa-miR-4637 | 86.0839 | NM_000633 |
| BCL2 | hsa-miR-3161 | 84.8188 | NM_000633 |
| BCL2 | hsa-miR-33a-3p | 84.8038 | NM_000633 |
| BCL2 | hsa-miR-511-3p | 83.7676 | NM_000633 |
| BCL2 | hsa-miR-557 | 83.5479 | NM_000633 |
| BCL2 | hsa-miR-153-3p | 83.0947 | NM_000633 |
| BCL2 | hsa-let-7g-3p | 82.1375 | NM_000633 |
| BCL2 | hsa-let-7a-2-3p | 82.1375 | NM_000633 |
| BCL2 | hsa-miR-4307 | 81.4712 | NM_000633 |
| BCL2 | hsa-miR-4755-5p | 81.2311 | NM_000633 |
| BCL2 | hsa-miR-5006-3p | 81.2311 | NM_000633 |
| BCL2 | hsa-miR-5011-5p | 81.1489 | NM_000633 |
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Motifs and transcription factors (TFs) regulating BCL2 |
| This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.) |
| Gene symbol | motif | TF_highConf |
| BCL2 | kznf__ZNF613_Imbeault2017_RP_RCADE | ZNF613 (directAnnotation). |
| BCL2 | metacluster_111.5 | E4F1; E4F1 (directAnnotation). |
| BCL2 | taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr | FLI1; FOXI1 (directAnnotation). |
| BCL2 | transfac_pro__M01237 | TERF1 (directAnnotation). |
| BCL2 | transfac_public__M00415 | ZEB1 (directAnnotation). |
| BCL2 | metacluster_52.10 | GTF3C2; ZNF436 (directAnnotation). |
| BCL2 | transfac_pro__M06528 | ZNF527 (directAnnotation). |
| BCL2 | metacluster_65.12 | ATF6 (directAnnotation). |
| BCL2 | metacluster_74.16 | HNF1A (directAnnotation). |
| BCL2 | transfac_pro__M06117 | ZNF23 (directAnnotation). |
| BCL2 | transfac_pro__M06339 | ZNF425 (directAnnotation). |
| BCL2 | taipale__MYBL2_DBD_AACCGTTAACGGNN | MYBL2 (directAnnotation). |
| BCL2 | transfac_pro__M05977 | ZNF257 (directAnnotation). |
| BCL2 | tfdimers__MD00260 | GTF2IRD1; IKZF2 (directAnnotation). |
| BCL2 | transfac_pro__M05939 | ZNF471 (directAnnotation). |
| BCL2 | transfac_pro__M02080 | ISL2 (directAnnotation). |
| BCL2 | transfac_pro__M06295 | ZNF667 (inferredBy_Orthology). |
| BCL2 | metacluster_130.14 | ZIM3 (directAnnotation). PRDM1 (inferredBy_Orthology). |
| BCL2 | taipale_tf_pairs__CUX1_PITX1_GGATTANNNNATCRATN_CAP_repr | CUX1; PITX1 (directAnnotation). |
| BCL2 | transfac_pro__M06544 | ZFP62 (directAnnotation). |
| BCL2 | kznf__ZBTB14_Schmitges2016_RCADE | ZBTB14 (directAnnotation). |
| BCL2 | dbtfbs__SETDB1_HEK293_ENCSR348AGV_merged_N1 | SETDB1 (directAnnotation). |
| BCL2 | kznf__ZNF2_Imbeault2017_RP_ChIP-seq | ZNF2 (directAnnotation). |
| BCL2 | taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP | ELK1; FOXO1 (directAnnotation). |
| BCL2 | taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr | ELK1; TBX21 (directAnnotation). |
| BCL2 | transfac_pro__M05397 | ZNF444 (directAnnotation). |
| BCL2 | metacluster_166.5 | ERG; ETV2; FLI1 (directAnnotation). |
| BCL2 | taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP | ETV4; GCM1 (directAnnotation). |
| BCL2 | jaspar__MA1963.1 | SATB1 (directAnnotation). |
| BCL2 | taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr | ETV2; SOX15 (directAnnotation). |
| BCL2 | hocomoco__DPRX_HUMAN.H11MO.0.D | DPRX (directAnnotation). |
| BCL2 | hdpi__NRL | NRL (directAnnotation). |
| BCL2 | flyfactorsurvey__Mad_FlyReg_FBgn0011648 | SMAD9 (inferredBy_Orthology). |
| BCL2 | cisbp__M00341 | PAX6 (directAnnotation). |
| BCL2 | cisbp__M00968 | MTF2 (directAnnotation). |
| BCL2 | hdpi__FEZF2 | FEZF2 (directAnnotation). |
| BCL2 | transfac_pro__M07310 | SP5 (directAnnotation). |
| BCL2 | metacluster_67.2 | ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology). |
| BCL2 | homer__TWVGGTCCGC_HINFP | HINFP (directAnnotation). |
| BCL2 | metacluster_61.1 | DEAF1; DEAF1 (directAnnotation). |
| BCL2 | metacluster_155.11 | SPZ1 (directAnnotation). |
| BCL2 | swissregulon__hs__ZBTB14 | ZBTB14 (directAnnotation). |
| BCL2 | kznf__ZNF548_Imbeault2017_RP_RCADE | ZNF548 (directAnnotation). |
| BCL2 | hdpi__HTATIP2 | HTATIP2 (directAnnotation). |
| BCL2 | hdpi__HIP2 | UBE2K (directAnnotation). |
| BCL2 | hdpi__ZNF304 | ZNF304 (directAnnotation). |
| BCL2 | transfac_pro__M01240 | GTF2IRD1 (directAnnotation). |
| BCL2 | metacluster_151.1 | KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation). |
| BCL2 | idmmpmm__Mad | SMAD9 (inferredBy_Orthology). |
| BCL2 | transfac_pro__M02089 | E2F3 (directAnnotation). |
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Acts as a transcription factor |
| This table shows that this differential gene acts as a transcription factor. |
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Acts as a drug target |
| This table shows that this differential gene acts as a drug target. |
| Target name | Drug name | Drug ID | Drug type |
| BCL2 | "AN-9" | DB05103 | small molecule |
| BCL2 | "Apoptone" | DB06307 | small molecule |
| BCL2 | "Dexibuprofen" | DB09213 | small molecule |
| BCL2 | "Docetaxel" | DB01248 | small molecule |
| BCL2 | "Eribulin" | DB08871 | small molecule |
| BCL2 | "Ibuprofen" | DB01050 | small molecule |
| BCL2 | "Navitoclax" | DB12340 | small molecule |
| BCL2 | "Obatoclax" | DB12191 | small molecule |
| BCL2 | "Oleandrin" | DB12843 | small molecule |
| BCL2 | "Paclitaxel docosahexaenoic acid" | DB05297 | small molecule |
| BCL2 | "Paclitaxel" | DB01229 | small molecule |
| BCL2 | "Rasagiline" | DB01367 | small molecule |
| BCL2 | "Terpinen-4-ol" | DB12816 | small molecule |
| BCL2 | "Venetoclax" | DB11581 | small molecule |
| Page: 1 |
| 1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
| 2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |
| 1 | MicroRNA-497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl-2 |
| 2 | Knockdown of the oncogene lncRNA NEAT1 restores the availability of miR-34c and improves the sensitivity to cisplatin in osteosarcoma |
| 3 | MicroRNA-630 may confer favorable cisplatin-based chemotherapy and clinical outcomes in non-small cell lung cancer by targeting Bcl-2 |
| 4 | MiRNA-21: a biomarker predictive for platinum-based adjuvant chemotherapy response in patients with non-small cell lung cancer |
| 5 | miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP |
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