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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BCL10

Summary for BCL10

Gene information	Gene symbol	BCL10
	Ensembl ID	ENSG00000142867
	Entrez ID	8915
	Gene name	BCL10 immune signaling adaptor
	Synonyms	c-E10\|CARMEN\|CIPER\|CLAP\|mE10
	Gene type	protein_coding
	UniProtAcc	O95999

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Dataset with differentially expressed gene: BCL10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.01221	1.59e-04
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.651657	0.00e+00

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Expression of BCL10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BCL10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
BCL10	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating BCL10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BCL10	hsa-miR-12136	99.6004	NM_003921
BCL10	hsa-miR-4775	99.0026	NM_003921
BCL10	hsa-miR-590-3p	98.368	NM_003921
BCL10	hsa-miR-372-5p	97.2713	NM_003921
BCL10	hsa-miR-5701	95.5802	NM_003921
BCL10	hsa-miR-5680	95.1774	NM_001320715
BCL10	hsa-miR-616-5p	94.9508	NM_003921
BCL10	hsa-miR-371b-5p	94.9508	NM_003921
BCL10	hsa-miR-373-5p	94.9508	NM_003921
BCL10	hsa-miR-4282	94.6434	NM_003921
BCL10	hsa-miR-622	91.4215	NM_003921
BCL10	hsa-miR-31-3p	91.2682	NM_003921
BCL10	hsa-miR-548k	90.9929	NM_003921
BCL10	hsa-miR-548av-5p	90.9929	NM_003921
BCL10	hsa-miR-8054	90.9929	NM_003921
BCL10	hsa-miR-3938	89.5347	NM_003921
BCL10	hsa-miR-4766-5p	89.4215	NM_003921
BCL10	hsa-miR-7159-3p	88.7841	NM_003921
BCL10	hsa-miR-3529-3p	88.7631	NM_003921
BCL10	hsa-miR-30e-5p	88.7178	NM_003921
BCL10	hsa-miR-30a-5p	88.7178	NM_003921
BCL10	hsa-miR-30b-5p	88.7178	NM_003921
BCL10	hsa-miR-30d-5p	88.7178	NM_003921
BCL10	hsa-miR-30c-5p	88.7178	NM_003921
BCL10	hsa-miR-371a-5p	88.3099	NM_003921
BCL10	hsa-miR-340-5p	88.1287	NM_003921
BCL10	hsa-miR-500a-5p	87.978	NM_003921
BCL10	hsa-miR-651-3p	86.2058	NM_003921
BCL10	hsa-miR-548c-3p	85.7694	NM_003921
BCL10	hsa-miR-450b-5p	83.2893	NM_003921
BCL10	hsa-miR-5704	83.0649	NM_003921
BCL10	hsa-miR-5582-3p	82.8496	NM_003921
BCL10	hsa-miR-3148	82.6307	NM_001320715

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Motifs and transcription factors (TFs) regulating BCL10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BCL10	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
BCL10	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
BCL10	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
BCL10	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
BCL10	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
BCL10	metacluster_135.11	NR2C2 (directAnnotation).
BCL10	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BCL10	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
BCL10	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
BCL10	hdpi__ZNF304	ZNF304 (directAnnotation).
BCL10	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
BCL10	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."