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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BCCIP

Summary for BCCIP

Gene information	Gene symbol	BCCIP
	Ensembl ID	ENSG00000107949
	Entrez ID	56647
	Gene name	BRCA2 and CDKN1A interacting protein
	Synonyms	BCCIPalpha\|TOK-1
	Gene type	protein_coding
	UniProtAcc	Q9P287

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Dataset with differentially expressed gene: BCCIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.12619	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.325086	1.29e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.368033	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.423681	2.58e-30
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.390158	8.53e-17
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.393304	8.02e-21
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.389181	8.64e-17

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Expression of BCCIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BCCIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BCCIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BCCIP	hsa-miR-597-5p	96.5872	NM_078469
BCCIP	hsa-miR-4778-3p	95.1974	NM_078468
BCCIP	hsa-miR-127-3p	93.9156	NM_078469
BCCIP	hsa-miR-6511b-5p	93.386	NM_078469
BCCIP	hsa-miR-6811-5p	93.386	NM_078469
BCCIP	hsa-miR-4427	93.2478	NM_078468
BCCIP	hsa-miR-203a-3p	93.1896	NM_078469
BCCIP	hsa-miR-7-2-3p	92.0539	NM_016567
BCCIP	hsa-miR-7-1-3p	92.0539	NM_016567
BCCIP	hsa-miR-4682	91.1024	NM_078468
BCCIP	hsa-miR-6760-3p	90.6979	NM_078468
BCCIP	hsa-miR-6124	89.4925	NM_078468
BCCIP	hsa-miR-4490	88.4101	NM_078468
BCCIP	hsa-miR-6769a-3p	88.1898	NM_016567
BCCIP	hsa-miR-374a-3p	87.9433	NM_016567
BCCIP	hsa-miR-545-3p	87.54	NM_078469
BCCIP	hsa-miR-4793-3p	86.2776	NM_078469
BCCIP	hsa-miR-29a-3p	86.1009	NM_078469
BCCIP	hsa-miR-29c-3p	86.1009	NM_078469
BCCIP	hsa-miR-29b-3p	86.1009	NM_078469
BCCIP	hsa-miR-7-5p	86.0228	NM_078469
BCCIP	hsa-miR-4517	85.041	NM_078469
BCCIP	hsa-miR-934	83.2432	NM_078469
BCCIP	hsa-miR-30e-3p	83.2406	NM_078468
BCCIP	hsa-miR-30a-3p	83.2406	NM_078468
BCCIP	hsa-miR-30d-3p	83.2406	NM_078468
BCCIP	hsa-miR-4742-3p	83.0851	NM_078469
BCCIP	hsa-miR-371a-5p	82.8418	NM_016567
BCCIP	hsa-miR-582-3p	82.3893	NM_078468
BCCIP	hsa-miR-6774-5p	81.9594	NM_078469
BCCIP	hsa-miR-635	81.9594	NM_078469
BCCIP	hsa-miR-4680-3p	81.0675	NM_078468
BCCIP	hsa-miR-592	80.8943	NM_078469

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Motifs and transcription factors (TFs) regulating BCCIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BCCIP	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
BCCIP	jaspar__MA0748.2	YY2 (directAnnotation).
BCCIP	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
BCCIP	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
BCCIP	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
BCCIP	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."