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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BCAM

Summary for BCAM

Gene information	Gene symbol	BCAM
	Ensembl ID	ENSG00000187244
	Entrez ID	4059
	Gene name	basal cell adhesion molecule (Lutheran blood group)
	Synonyms	CD239\|LU
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: BCAM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.44056	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.503597	0.00e+00

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Expression of BCAM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BCAM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BCAM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BCAM	hsa-miR-3605-5p	99.965	NM_001013257
BCAM	hsa-miR-6857-5p	99.8746	NM_001013257
BCAM	hsa-miR-4492	99.4656	NM_001013257
BCAM	hsa-miR-6894-5p	98.7032	NM_001013257
BCAM	hsa-miR-6810-5p	98.2859	NM_001013257
BCAM	hsa-miR-7154-3p	97.65	NM_001013257
BCAM	hsa-miR-4450	97.3803	NM_001013257
BCAM	hsa-miR-92a-1-5p	97.339	NM_001013257
BCAM	hsa-miR-762	97.2797	NM_001013257
BCAM	hsa-miR-765	97.1613	NM_001013257
BCAM	hsa-miR-4498	97.0594	NM_001013257
BCAM	hsa-miR-5001-5p	97.0594	NM_001013257
BCAM	hsa-miR-11181-3p	96.4697	NM_001013257
BCAM	hsa-miR-6855-5p	96.1801	NM_001013257
BCAM	hsa-miR-766-5p	96.1291	NM_001013257
BCAM	hsa-miR-450a-2-3p	95.3924	NM_001013257
BCAM	hsa-miR-199a-5p	95.2549	NM_001013257
BCAM	hsa-miR-199b-5p	95.2549	NM_001013257
BCAM	hsa-miR-3679-5p	94.6112	NM_001013257
BCAM	hsa-miR-185-3p	94.4422	NM_001013257
BCAM	hsa-miR-92a-2-5p	93.9533	NM_001013257
BCAM	hsa-miR-6734-5p	93.7088	NM_001013257
BCAM	hsa-miR-4651	93.372	NM_001013257
BCAM	hsa-miR-608	92.5689	NM_001013257
BCAM	hsa-miR-2110	92.317	NM_001013257
BCAM	hsa-miR-1185-5p	92.1685	NM_001013257
BCAM	hsa-miR-6763-5p	91.8689	NM_001013257
BCAM	hsa-miR-3170	91.1754	NM_001013257
BCAM	hsa-miR-28-5p	90.6424	NM_001013257
BCAM	hsa-miR-3139	90.6424	NM_001013257
BCAM	hsa-miR-708-5p	90.6424	NM_001013257
BCAM	hsa-miR-4283	90.2955	NM_001013257
BCAM	hsa-miR-3689d	90.2498	NM_001013257
BCAM	hsa-miR-6851-5p	90.2498	NM_001013257
BCAM	hsa-miR-5187-5p	89.2424	NM_001013257
BCAM	hsa-miR-3150a-3p	88.9187	NM_001013257
BCAM	hsa-miR-7155-5p	88.4485	NM_001013257
BCAM	hsa-miR-8085	86.9461	NM_001013257
BCAM	hsa-miR-6731-5p	86.9461	NM_001013257
BCAM	hsa-miR-6798-5p	84.7458	NM_001013257
BCAM	hsa-miR-6873-5p	84.1019	NM_005581
BCAM	hsa-miR-323a-5p	83.9871	NM_001013257
BCAM	hsa-miR-6876-5p	83.7452	NM_005581
BCAM	hsa-miR-4476	83.7452	NM_005581
BCAM	hsa-miR-1227-5p	83.6234	NM_001013257
BCAM	hsa-miR-3198	82.0959	NM_001013257
BCAM	hsa-miR-6756-5p	81.2362	NM_001013257
BCAM	hsa-miR-4764-5p	81.1966	NM_001013257
BCAM	hsa-miR-4721	80.6759	NM_001013257
BCAM	hsa-miR-6825-5p	80.3694	NM_001013257

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Motifs and transcription factors (TFs) regulating BCAM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BCAM	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."