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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BBS7

Summary for BBS7

Gene information	Gene symbol	BBS7
	Ensembl ID	ENSG00000138686
	Entrez ID	55212
	Gene name	Bardet-Biedl syndrome 7
	Synonyms	BBS2L1\|FLJ10715
	Gene type	protein_coding
	UniProtAcc	Q8IWZ6

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Dataset with differentially expressed gene: BBS7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.373271	0.00e+00

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Expression of BBS7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BBS7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BBS7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BBS7	hsa-miR-5011-5p	99.4371	NM_176824
BBS7	hsa-miR-501-5p	94.3435	NM_018190
BBS7	hsa-miR-6796-3p	90.8827	NM_018190
BBS7	hsa-miR-190a-3p	90.2201	NM_176824
BBS7	hsa-miR-3159	90.2	NM_176824
BBS7	hsa-miR-1277-5p	89.9451	NM_176824
BBS7	hsa-miR-1258	87.6663	NM_176824
BBS7	hsa-miR-513b-3p	87.6471	NM_176824
BBS7	hsa-miR-5582-3p	87.4052	NM_176824
BBS7	hsa-miR-302c-5p	87.0587	NM_176824
BBS7	hsa-miR-758-5p	86.5895	NM_176824
BBS7	hsa-miR-335-3p	85.1276	NM_176824
BBS7	hsa-miR-1297	84.6186	NM_018190
BBS7	hsa-miR-3189-3p	84.554	NM_018190
BBS7	hsa-miR-372-5p	83.4309	NM_176824
BBS7	hsa-miR-3611	83.3947	NM_176824
BBS7	hsa-miR-4780	82.2629	NM_176824
BBS7	hsa-miR-3143	82.1703	NM_176824
BBS7	hsa-miR-6755-3p	81.9546	NM_018190
BBS7	hsa-miR-623	81.5443	NM_176824
BBS7	hsa-miR-130a-5p	81.1653	NM_176824
BBS7	hsa-miR-26a-5p	81.106	NM_018190
BBS7	hsa-miR-26b-5p	81.106	NM_018190
BBS7	hsa-miR-4465	81.106	NM_018190
BBS7	hsa-miR-4775	80.4773	NM_176824

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Motifs and transcription factors (TFs) regulating BBS7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BBS7	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
BBS7	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."