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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BBC3

Summary for BBC3

Gene information	Gene symbol	BBC3
	Ensembl ID	ENSG00000105327
	Entrez ID	27113
	Gene name	BCL2 binding component 3
	Synonyms	JFY1\|PUMA
	Gene type	protein_coding
	UniProtAcc	Q9BXH1

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Dataset with differentially expressed gene: BBC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.335372	7.07e-19
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.751713	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.368506	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.275991	1.20e-15

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Expression of BBC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BBC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
BBC3	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating BBC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BBC3	hsa-let-7a-2-3p	90.8375	NM_001127241
BBC3	hsa-let-7g-3p	90.8375	NM_001127241
BBC3	hsa-miR-29a-5p	89.4613	NM_001127240
BBC3	hsa-miR-144-3p	89.0797	NM_001127241
BBC3	hsa-miR-1200	85.4877	NM_001127241
BBC3	hsa-miR-96-3p	85.2901	NM_001127240
BBC3	hsa-miR-4505	85.0799	NM_001127240
BBC3	hsa-miR-4496	84.6967	NM_001127240
BBC3	hsa-miR-4652-5p	84.1187	NM_001127241
BBC3	hsa-miR-5787	83.9725	NM_001127240
BBC3	hsa-miR-4324	83.7371	NM_001127241
BBC3	hsa-miR-4732-3p	83.5677	NM_001127241
BBC3	hsa-miR-222-3p	81.6439	NM_001127241
BBC3	hsa-miR-221-3p	81.6439	NM_001127241

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Motifs and transcription factors (TFs) regulating BBC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BBC3	transfac_pro__M01299	MECP2 (directAnnotation).
BBC3	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
BBC3	transfac_pro__M04826	EP300 (directAnnotation).
BBC3	cisbp__M08198	ELF1 (directAnnotation).
BBC3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
BBC3	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
BBC3	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
BBC3	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
BBC3	jaspar__MA0502.2	NFYB (directAnnotation).
BBC3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
BBC3	metacluster_22.17	NFE2 (directAnnotation).
BBC3	cisbp__M01725	SREBF2 (inferredBy_Orthology).
BBC3	metacluster_22.19	NFE2 (directAnnotation).
BBC3	metacluster_57.2	BACH1; MITF; MITF; TFE3; TFE3; TFE3; TFEB; USF2 (directAnnotation). MITF; TFE3; USF1; USF2 (inferredBy_Orthology).
BBC3	jaspar__MA1562.1	SOX14 (directAnnotation).
BBC3	metacluster_14.23	TFE3 (directAnnotation).
BBC3	transfac_pro__M05942	ZNF700 (directAnnotation).
BBC3	transfac_pro__M06084	ZNF208 (directAnnotation).
BBC3	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
BBC3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
BBC3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
BBC3	metacluster_143.13	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."