Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BARD1

Summary for BARD1

Gene information	Gene symbol	BARD1
	Ensembl ID	ENSG00000138376
	Entrez ID	580
	Gene name	BRCA1 associated RING domain 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q99728

Top

Dataset with differentially expressed gene: BARD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.603231	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.287817	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.477556	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.33966	1.54e-44

Top

Expression of BARD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to BARD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating BARD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BARD1	hsa-miR-580-5p	97.8752	NM_000465
BARD1	hsa-miR-300	96.8447	NM_001282549
BARD1	hsa-miR-381-3p	96.8447	NM_001282549
BARD1	hsa-miR-4261	96.2614	NM_001282549
BARD1	hsa-miR-551b-5p	95.0399	NM_001282549
BARD1	hsa-miR-4736	93.2119	NM_001282549
BARD1	hsa-miR-6830-5p	91.6139	NM_001282549
BARD1	hsa-miR-147b-5p	91.2568	NM_001282549
BARD1	hsa-miR-1297	91.0114	NM_001282549
BARD1	hsa-miR-103a-2-5p	90.7297	NM_001282549
BARD1	hsa-miR-103a-1-5p	90.7297	NM_001282549
BARD1	hsa-miR-8063	88.8125	NM_001282549
BARD1	hsa-miR-5697	88.8122	NM_001282549
BARD1	hsa-miR-5692a	88.4154	NM_001282549
BARD1	hsa-miR-548d-3p	88.3427	NM_001282549
BARD1	hsa-miR-548h-3p	88.3427	NM_001282549
BARD1	hsa-miR-548z	88.3427	NM_001282549
BARD1	hsa-miR-548ac	88.3427	NM_001282549
BARD1	hsa-miR-548bb-3p	88.3427	NM_001282549
BARD1	hsa-miR-340-5p	88.0836	NM_001282549
BARD1	hsa-miR-4698	86.0846	NM_001282549
BARD1	hsa-miR-569	85.7039	NM_001282549
BARD1	hsa-miR-4477a	84.3824	NM_001282549
BARD1	hsa-miR-3613-3p	84.3684	NM_001282549
BARD1	hsa-miR-3152-3p	83.2543	NM_001282549
BARD1	hsa-miR-4775	83.1636	NM_001282549
BARD1	hsa-miR-26b-5p	81.5584	NM_001282549
BARD1	hsa-miR-26a-5p	81.5584	NM_001282549
BARD1	hsa-miR-371a-5p	80.9941	NM_001282549
BARD1	hsa-miR-4496	80.1963	NM_001282549

Page: 1

Top

Motifs and transcription factors (TFs) regulating BARD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BARD1	metacluster_7.13	ZFX (directAnnotation).
BARD1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
BARD1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
BARD1	metacluster_151.2	ZNF23 (directAnnotation).
BARD1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
BARD1	transfac_pro__M05479	ZNF580 (directAnnotation).
BARD1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
BARD1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BARD1	metacluster_182.10	ZFX (directAnnotation).
BARD1	hdpi__ETV4	ETV4 (directAnnotation).
BARD1	transfac_pro__M05628	ZNF735 (directAnnotation).
BARD1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
BARD1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
BARD1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BARD1	jaspar__MA0079.5	SP1 (directAnnotation).
BARD1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
BARD1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
BARD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BARD1	transfac_pro__M07397	ZNF148 (directAnnotation).
BARD1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
BARD1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
BARD1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
BARD1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
BARD1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
BARD1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
BARD1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
BARD1	transfac_pro__M01175	ZBTB7B (directAnnotation).
BARD1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
BARD1	tfdimers__MD00151	CHURC1 (directAnnotation).
BARD1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
BARD1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
BARD1	transfac_pro__M01303	SP1 (directAnnotation).
BARD1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
BARD1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
BARD1	transfac_pro__M02090	E2F4 (directAnnotation).
BARD1	transfac_pro__M01714	KLF15 (directAnnotation).
BARD1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
BARD1	jaspar__MA1122.1	TFDP1 (directAnnotation).
BARD1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
BARD1	transfac_pro__M02089	E2F3 (directAnnotation).
BARD1	metacluster_3.14	WT1; WT1 (directAnnotation).
BARD1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
BARD1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
BARD1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
BARD1	cisbp__M07938	E2F1 (directAnnotation).
BARD1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
BARD1	transfac_pro__M07436	WT1 (directAnnotation).
BARD1	transfac_pro__M02281	SP1 (directAnnotation).
BARD1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
BARD1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."