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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BAMBI

Summary for BAMBI

Gene information	Gene symbol	BAMBI
	Ensembl ID	ENSG00000095739
	Entrez ID	25805
	Gene name	BMP and activin membrane bound inhibitor
	Synonyms	NMA
	Gene type	protein_coding
	UniProtAcc	Q13145

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Dataset with differentially expressed gene: BAMBI

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	1.49323	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.981656	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.339354	9.06e-24
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.461958	7.93e-43

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Expression of BAMBI in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BAMBI

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BAMBI

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BAMBI	hsa-miR-5011-5p	99.0842	NM_012342
BAMBI	hsa-miR-6895-3p	97.7023	NM_012342
BAMBI	hsa-miR-500a-5p	93.6593	NM_012342
BAMBI	hsa-miR-593-3p	90.8051	NM_012342
BAMBI	hsa-miR-6818-3p	90.1553	NM_012342
BAMBI	hsa-miR-19a-3p	88.9691	NM_012342
BAMBI	hsa-miR-19b-3p	88.9691	NM_012342
BAMBI	hsa-miR-513c-3p	87.9667	NM_012342
BAMBI	hsa-miR-513a-3p	87.9667	NM_012342
BAMBI	hsa-miR-548e-5p	87.8766	NM_012342
BAMBI	hsa-miR-10527-5p	87.7376	NM_012342
BAMBI	hsa-miR-106b-5p	86.3714	NM_012342
BAMBI	hsa-miR-20a-5p	86.3714	NM_012342
BAMBI	hsa-miR-1277-5p	85.8535	NM_012342
BAMBI	hsa-miR-95-5p	83.9834	NM_012342
BAMBI	hsa-miR-5000-5p	83.5919	NM_012342
BAMBI	hsa-miR-4311	83.4433	NM_012342
BAMBI	hsa-miR-3606-3p	83.298	NM_012342
BAMBI	hsa-miR-4753-3p	81.7226	NM_012342
BAMBI	hsa-miR-1252-3p	81.5838	NM_012342
BAMBI	hsa-miR-12125	80.593	NM_012342

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Motifs and transcription factors (TFs) regulating BAMBI

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BAMBI	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
BAMBI	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
BAMBI	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
BAMBI	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
BAMBI	transfac_public__M00278	GATA1; LDB1; LMO2; TAL1; TCF3 (inferredBy_Orthology).
BAMBI	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
BAMBI	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
BAMBI	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
BAMBI	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
BAMBI	jaspar__MA1957.1	ELK1 (directAnnotation).
BAMBI	metacluster_135.11	NR2C2 (directAnnotation).
BAMBI	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BAMBI	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BAMBI	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
BAMBI	cisbp__M00968	MTF2 (directAnnotation).
BAMBI	metacluster_160.20	JUND; PRDM15 (directAnnotation).
BAMBI	cisbp__M00341	PAX6 (directAnnotation).
BAMBI	metacluster_198.3	ZFP64 (directAnnotation).
BAMBI	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BAMBI	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BAMBI	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
BAMBI	cisbp__M00788	ZFY (inferredBy_Orthology).
BAMBI	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
BAMBI	metacluster_175.1	ZNF283 (directAnnotation).
BAMBI	hdpi__ZNF304	ZNF304 (directAnnotation).
BAMBI	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
BAMBI	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
BAMBI	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BAMBI	transfac_pro__M01199	TRIM28 (directAnnotation).
BAMBI	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
BAMBI	metacluster_151.2	ZNF23 (directAnnotation).
BAMBI	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BAMBI	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BAMBI	transfac_pro__M03806	ZBTB7C (directAnnotation).
BAMBI	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BAMBI	transfac_pro__M05981	ZNF233 (directAnnotation).
BAMBI	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
BAMBI	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
BAMBI	transfac_pro__M06111	ZNF254 (directAnnotation).
BAMBI	metacluster_172.6	CHD2; E2F1 (directAnnotation).
BAMBI	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."