Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BAK1

Summary for BAK1

Gene information	Gene symbol	BAK1
	Ensembl ID	ENSG00000030110
	Entrez ID	578
	Gene name	BCL2 antagonist/killer 1
	Synonyms	BAK\|BCL2L7\|CDN1
	Gene type	protein_coding
	UniProtAcc	Q16611

Top

Dataset with differentially expressed gene: BAK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.558861	4.11e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.514511	2.47e-36

Top

Expression of BAK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to BAK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
BAK1	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating BAK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BAK1	hsa-miR-4319	97.6542	NM_001188
BAK1	hsa-miR-125b-5p	96.5924	NM_001188
BAK1	hsa-miR-125a-5p	96.5924	NM_001188
BAK1	hsa-miR-4739	95.7236	NM_001188
BAK1	hsa-miR-6778-3p	94.6015	NM_001188
BAK1	hsa-miR-4756-5p	94.2125	NM_001188
BAK1	hsa-miR-1321	94.2125	NM_001188
BAK1	hsa-miR-1909-3p	91.3145	NM_001188
BAK1	hsa-miR-6722-3p	91.1686	NM_001188
BAK1	hsa-miR-7106-5p	89.9817	NM_001188
BAK1	hsa-miR-670-5p	88.0855	NM_001188
BAK1	hsa-miR-6073	87.5536	NM_001188
BAK1	hsa-miR-1297	86.8131	NM_001188
BAK1	hsa-miR-5682	84.9992	NM_001188
BAK1	hsa-miR-4732-3p	84.8654	NM_001188
BAK1	hsa-miR-503-3p	84.7072	NM_001188
BAK1	hsa-miR-26b-5p	84.2132	NM_001188
BAK1	hsa-miR-26a-5p	84.2132	NM_001188
BAK1	hsa-miR-4700-5p	83.1706	NM_001188
BAK1	hsa-miR-29b-3p	82.5254	NM_001188
BAK1	hsa-miR-29c-3p	82.5254	NM_001188
BAK1	hsa-miR-29a-3p	82.5254	NM_001188
BAK1	hsa-miR-4465	81.5868	NM_001188
BAK1	hsa-miR-345-3p	81.1974	NM_001188
BAK1	hsa-miR-4667-5p	80.7539	NM_001188

Page: 1

Top

Motifs and transcription factors (TFs) regulating BAK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BAK1	taipale_cyt_meth__LBX2_CTCGTTAN_eDBD	LBX2 (directAnnotation).
BAK1	transfac_pro__M06564	ZNF578 (directAnnotation).
BAK1	jaspar__MA1948.1	ETV5 (directAnnotation).
BAK1	transfac_pro__M06372	ZNF841 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."