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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BACE2

Summary for BACE2

Gene information	Gene symbol	BACE2
	Ensembl ID	ENSG00000182240
	Entrez ID	25825
	Gene name	beta-secretase 2
	Synonyms	AEPLC\|ALP56\|CEAP1\|DRAP
	Gene type	protein_coding
	UniProtAcc	Q9Y5Z0

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Dataset with differentially expressed gene: BACE2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.452601	4.77e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.886139	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.10818	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.29198	0.00e+00

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Expression of BACE2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BACE2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BACE2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BACE2	hsa-miR-520a-5p	96.8209	NM_138991
BACE2	hsa-miR-525-5p	96.8209	NM_138991
BACE2	hsa-miR-607	95.0823	NM_138992
BACE2	hsa-miR-3658	94.4946	NM_138991
BACE2	hsa-miR-4503	92.6333	NM_138991
BACE2	hsa-miR-7152-5p	92.572	NM_138991
BACE2	hsa-miR-3180-5p	91.8211	NM_138992
BACE2	hsa-miR-3148	88.8514	NM_138991
BACE2	hsa-miR-4739	86.9468	NM_138992
BACE2	hsa-miR-4756-5p	86.9468	NM_138992
BACE2	hsa-miR-1321	86.9468	NM_138992
BACE2	hsa-miR-6512-3p	86.8362	NM_138992
BACE2	hsa-miR-6720-5p	86.8362	NM_138992
BACE2	hsa-miR-12123	86.7116	NM_138992
BACE2	hsa-miR-4709-3p	85.0023	NM_138991
BACE2	hsa-miR-1225-5p	84.3727	NM_138991
BACE2	hsa-miR-5582-5p	83.699	NM_138991
BACE2	hsa-miR-3671	83.4319	NM_138992
BACE2	hsa-miR-4297	82.4177	NM_138992
BACE2	hsa-miR-659-3p	82.0189	NM_138992
BACE2	hsa-miR-4755-5p	81.5832	NM_138991
BACE2	hsa-miR-5006-3p	81.5832	NM_138991
BACE2	hsa-miR-6830-5p	81.2635	NM_138991
BACE2	hsa-miR-576-5p	80.3642	NM_138991
BACE2	hsa-miR-3184-3p	80.2158	NM_138991
BACE2	hsa-miR-4751	80.0334	NM_138991
BACE2	hsa-miR-516b-5p	80.0142	NM_138991

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Motifs and transcription factors (TFs) regulating BACE2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BACE2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
BACE2	hdpi__ETV4	ETV4 (directAnnotation).
BACE2	jaspar__MA0079.5	SP1 (directAnnotation).
BACE2	transfac_pro__M04826	EP300 (directAnnotation).
BACE2	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
BACE2	transfac_pro__M06035	ZNF749 (directAnnotation).
BACE2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
BACE2	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
BACE2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
BACE2	cisbp__M00968	MTF2 (directAnnotation).
BACE2	cisbp__M00341	PAX6 (directAnnotation).
BACE2	metacluster_198.3	ZFP64 (directAnnotation).
BACE2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BACE2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
BACE2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
BACE2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BACE2	transfac_pro__M01199	TRIM28 (directAnnotation).
BACE2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BACE2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BACE2	transfac_pro__M03806	ZBTB7C (directAnnotation).
BACE2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BACE2	homer__GKTAATGR_Nkx6.1	NKX6-1 (inferredBy_Orthology).
BACE2	metacluster_51.10	HOXA5 (directAnnotation).
BACE2	metacluster_51.30	HOXB7 (directAnnotation).
BACE2	metacluster_51.22	MEOX1 (directAnnotation).
BACE2	metacluster_51.7	VAX1 (directAnnotation).
BACE2	metacluster_51.8	HOXB2 (directAnnotation).
BACE2	metacluster_51.17	HOXB5 (directAnnotation).
BACE2	metacluster_51.6	EMX1 (directAnnotation).
BACE2	tfdimers__MD00024	FOXO1; PAX4 (directAnnotation).
BACE2	taipale_tf_pairs__GCM2_PITX1_RTRCGGGSGATTAN_CAP_repr	GCM2; PITX1 (directAnnotation).
BACE2	jaspar__MA0707.2	MNX1 (directAnnotation).
BACE2	metacluster_51.29	HOXD8 (directAnnotation).
BACE2	taipale_tf_pairs__ELK1_HOXA3_NCCGGWNNNNNNNNNNNSCATTAN_CAP_repr	ELK1; HOXA3 (directAnnotation).
BACE2	metacluster_51.19	HOXD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."