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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: B3GLCT

Summary for B3GLCT

Gene information	Gene symbol	B3GLCT
	Ensembl ID	ENSG00000187676
	Entrez ID	145173
	Gene name	beta 3-glucosyltransferase
	Synonyms	B3GALTL\|B3Glc-T\|B3GTL
	Gene type	protein_coding
	UniProtAcc	Q6Y288

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Dataset with differentially expressed gene: B3GLCT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.14838	3.09e-02

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Expression of B3GLCT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to B3GLCT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating B3GLCT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
B3GLCT	hsa-miR-29a-5p	99.0544	NM_194318
B3GLCT	hsa-miR-135b-5p	98.032	NM_194318
B3GLCT	hsa-miR-135a-5p	98.032	NM_194318
B3GLCT	hsa-miR-548e-5p	96.9846	NM_194318
B3GLCT	hsa-miR-548az-3p	95.5034	NM_194318
B3GLCT	hsa-miR-548a-3p	94.7599	NM_194318
B3GLCT	hsa-miR-548e-3p	94.6381	NM_194318
B3GLCT	hsa-miR-548ar-3p	94.6381	NM_194318
B3GLCT	hsa-miR-548bc	94.6381	NM_194318
B3GLCT	hsa-miR-548f-3p	94.6381	NM_194318
B3GLCT	hsa-miR-3613-3p	93.4808	NM_194318
B3GLCT	hsa-miR-4762-3p	93.383	NM_194318
B3GLCT	hsa-miR-5011-5p	92.9764	NM_194318
B3GLCT	hsa-miR-539-5p	91.9665	NM_194318
B3GLCT	hsa-miR-6809-3p	91.9164	NM_194318
B3GLCT	hsa-let-7a-3p	91.7107	NM_194318
B3GLCT	hsa-miR-200b-3p	91.5648	NM_194318
B3GLCT	hsa-miR-200c-3p	91.5648	NM_194318
B3GLCT	hsa-miR-429	91.5648	NM_194318
B3GLCT	hsa-miR-4753-3p	90.5169	NM_194318
B3GLCT	hsa-miR-410-3p	90.1215	NM_194318
B3GLCT	hsa-miR-190a-3p	89.4244	NM_194318
B3GLCT	hsa-miR-6508-5p	89.3518	NM_194318
B3GLCT	hsa-miR-7-5p	89.3351	NM_194318
B3GLCT	hsa-let-7b-3p	88.9602	NM_194318
B3GLCT	hsa-miR-95-5p	88.5143	NM_194318
B3GLCT	hsa-miR-6873-3p	87.8585	NM_194318
B3GLCT	hsa-miR-6833-3p	87.3945	NM_194318
B3GLCT	hsa-miR-641	87.2625	NM_194318
B3GLCT	hsa-miR-3617-5p	87.2625	NM_194318
B3GLCT	hsa-let-7f-1-3p	85.3754	NM_194318
B3GLCT	hsa-miR-98-3p	85.3754	NM_194318
B3GLCT	hsa-miR-6875-3p	85.3696	NM_194318
B3GLCT	hsa-miR-146b-3p	85.3564	NM_194318
B3GLCT	hsa-miR-4441	85.1864	NM_194318
B3GLCT	hsa-miR-4768-5p	84.0441	NM_194318
B3GLCT	hsa-miR-4275	83.7946	NM_194318
B3GLCT	hsa-miR-8067	83.5437	NM_194318
B3GLCT	hsa-miR-12136	83.072	NM_194318
B3GLCT	hsa-miR-4680-3p	83.0296	NM_194318
B3GLCT	hsa-miR-548g-3p	82.9484	NM_194318
B3GLCT	hsa-miR-4446-5p	82.0748	NM_194318
B3GLCT	hsa-miR-6776-3p	81.1409	NM_194318
B3GLCT	hsa-miR-6780a-3p	80.5358	NM_194318
B3GLCT	hsa-miR-4775	80.3382	NM_194318
B3GLCT	hsa-miR-6754-5p	80.1986	NM_194318
B3GLCT	hsa-miR-4270	80.0653	NM_194318
B3GLCT	hsa-miR-6878-5p	80.0106	NM_194318

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Motifs and transcription factors (TFs) regulating B3GLCT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
B3GLCT	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
B3GLCT	transfac_pro__M00716	ZBTB14 (directAnnotation).
B3GLCT	swissregulon__hs__CHD1	CHD1 (directAnnotation).
B3GLCT	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
B3GLCT	transfac_pro__M04893	TAF1 (directAnnotation).
B3GLCT	transfac_pro__M03876	ZBTB33 (directAnnotation).
B3GLCT	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
B3GLCT	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."