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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: B2M

Summary for B2M

Gene informationGene symbol

B2M

Ensembl ID

ENSG00000273686

Entrez ID

567

Gene namebeta-2-microglobulin
SynonymsNA
Gene typeprotein_coding
UniProtAcc

P61769


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Dataset with differentially expressed gene: B2M

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells0.6076741.70e-11

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-0.8264880.00e+00

GSE138267

CDXTumor tissueLung cancerSmall cell lung cancer (SCLC)ChemotherapyNANAMalignant cells1.721380.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostNK cells0.3598620.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostCD8+ T cells0.3703330.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostCD4+ T cells0.2569190.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelprecDCs-0.3398754.85e-15

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro-0.6238180.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD8+ T cells-0.4095920.00e+00

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelprecDCs-0.3569823.22e-02

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelprePlasma cells0.4145931.98e-20

GSE153697

patientsBone marrow aspirateAcute lymphoblastic leukemiaRelapsed B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyanti-CD19 CAR-TNAMalignant cells0.2725411.48e-19

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostCD8+ T cells0.2647040.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelprecDCs-0.518718.56e-36

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostCD4+ T cells0.2591530.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostB cells0.7127070.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostMono/Macro0.3534521.34e-06

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelprePlasma cells-0.3644425.93e-29

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreMono/Macro-0.5446270.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreMast cells-0.7870341.55e-04

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelprepDCs-0.3783322.95e-03

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD8+ T cells0.3703562.20e-05

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD4+ T cells-0.7473531.22e-06

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAErythrocytes-0.9780230.00e+00

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD4+ T cells-0.3503870.00e+00

GSE150930

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaMucosa-assisted lymphoid tissue (MALT) lymphomaImmunotherapyrituximab + cyclophosphamide + fludarabineNAMalignant cells0.5063510.00e+00

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postPlasma cells0.5944951.09e-03

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMast cells1.275035.70e-06

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postNeutrophils0.2899845.15e-22

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD8+ T cells0.3066560.00e+00

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMono/Macro0.4487231.01e-17

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postB cells0.3474121.35e-07

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD4+ T cells0.3773061.40e-45

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD8+ T cells0.3207740.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD4+ T cells-0.317932.26e-29

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postB cells-0.8501452.56e-16

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMalignant cells0.6757271.64e-22

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postNeutrophils0.2794494.67e-20

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostMalignant cells1.225170.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMalignant cells0.9670890.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreNK cells0.3295253.10e-17

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells0.2589930.00e+00

GSE149214

PC9 cell lineCell lineLung cancerEGFR-mutated non-small cell lung cancer (NSCLC)Targeted therapyerlotinibNAMalignant cells0.5440570.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostcDCs0.281385.66e-22

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostMalignant cells0.320630.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostErythrocytes0.7698931.83e-08

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpreErythrocytes-1.160146.05e-05

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells0.39030.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostB cells0.9560131.23e-03

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells0.4887870.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells-0.2756150.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreErythrocytes-1.16930.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreMalignant cells-0.4006070.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreB cells-0.5076341.85e-02

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreNK cells0.3107845.64e-14

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostMalignant cells0.7708530.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostCD4+ T cells0.7537121.77e-30

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostNK cells1.160890.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostCD8+ T cells0.7384920.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD8+ T cells0.5241920.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreNK cells0.4766931.56e-04

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells-0.2611681.99e-27

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells0.5002440.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostCD4+ T cells-0.3684489.03e-15

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostMalignant cells0.4837370.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-1.43230.00e+00

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells-1.250020.00e+00

GSE164897_Vem

A375 cell lineCell lineMelanomaBRAFV600E-mutant melanomaTargeted therapyvemurafenibNAMalignant cells0.2561640.00e+00

GSE164897_VemCob

A375 cell lineCell lineMelanomaBRAFV600E-mutant melanomaTargeted therapyvemurafenib + combimetinibNAMalignant cells1.686590.00e+00

GSE164897_VemTra

A375 cell lineCell lineMelanomaB+E2:E57RAFV600E-mutant melanomaTargeted therapyvemurafenib + trametinibNAMalignant cells1.996680.00e+00

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Expression of B2M in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to B2M

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating B2M

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
B2Mhsa-miR-211395.4566NM_004048
B2Mhsa-miR-195-3p86.1354NM_004048
B2Mhsa-miR-16-2-3p86.1354NM_004048
B2Mhsa-miR-3679-3p85.9952NM_004048
B2Mhsa-miR-548ax85.0748NM_004048
B2Mhsa-miR-548ao-5p85.0748NM_004048
B2Mhsa-miR-449584.8154NM_004048
B2Mhsa-miR-314381.652NM_004048
B2Mhsa-miR-4796-3p81.4806NM_004048
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Motifs and transcription factors (TFs) regulating B2M

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
B2Mcisbp__M00808MYPOP (inferredBy_Orthology).
B2Mmetacluster_198.7AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
B2Mhdpi__TP73TP73 (directAnnotation).
B2Mhocomoco__TYY2_HUMAN.H11MO.0.DYY2 (directAnnotation).
B2Mtransfac_pro__M02090E2F4 (directAnnotation).
B2Mkznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
B2Mkznf__ZNF282_Imbeault2017_OM_RCADEZNF282 (directAnnotation).
B2Mtransfac_pro__M06304ZNF260 (directAnnotation).
B2Mtransfac_pro__M05574ZFP92 (directAnnotation).
B2Mmetacluster_174.2CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
B2Mswissregulon__mm__E2f7E2F7 (inferredBy_Orthology).
B2Mtransfac_pro__M00652NRF1 (directAnnotation).
B2Mtransfac_pro__M06952BATF (directAnnotation).
B2Mtransfac_pro__M12441ZNF281 (inferredBy_Orthology).
B2Mtransfac_pro__M05349SNAI3 (directAnnotation).
B2Mtransfac_pro__M06196ZNF81 (directAnnotation).
B2Mmetacluster_2.9IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
B2Mtransfac_pro__M05804ZBTB41 (inferredBy_Orthology).
B2Mtransfac_pro__M05798ZNF517 (directAnnotation).
B2Mtransfac_pro__M00767RXRA (directAnnotation). NR1H4 (inferredBy_Orthology).
B2Mtransfac_pro__M06107ZNF43 (directAnnotation).
B2Mtransfac_pro__M05397ZNF444 (directAnnotation).
B2Mjaspar__MA1125.1ZNF384 (directAnnotation).
B2Mmetacluster_141.6MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
B2Mtaipale__YY2_DBD_NNCCGCCATNW_reprYY2 (directAnnotation).
B2Mmetacluster_141.4GLIS2 (directAnnotation).
B2Mjaspar__MA0748.2YY2 (directAnnotation).
B2Mtransfac_pro__M06259ZNF91 (directAnnotation).
B2Mhdpi__TIMELESSTIMELESS (directAnnotation).
B2Mmetacluster_141.9TAF1; YY1; YY1 (directAnnotation).
B2Mtaipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_reprFLI1; FOXI1 (directAnnotation).
B2Mtfdimers__MD00066ELF1 (directAnnotation).
B2Mtfdimers__MD00302IRF7; IRF8 (directAnnotation).
B2Mtaipale_tf_pairs__GCM1_FIGLA_CAGCTGNNNNNNNNTGCGGG_CAPFIGLA; GCM1 (directAnnotation).
B2Mjaspar__MA1721.1ZNF93 (directAnnotation).
B2Mkznf__ZNF383_Imbeault2017_OM_RCADEZNF383 (directAnnotation).
B2Mtransfac_pro__M06230ZSCAN2 (inferredBy_Orthology).
B2Mtransfac_pro__M06334ZNF782 (directAnnotation).
B2Mtaipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_reprERF; HOXA3 (directAnnotation).
B2Mmetacluster_141.2E2F2; E2F3 (directAnnotation).
B2Mstark__RCGCMATTWYY1 (inferredBy_Orthology).
B2Mtfdimers__MD00475FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND; ZNF333 (directAnnotation).
B2Mtransfac_pro__M06237ZNF846 (directAnnotation).
B2Mcisbp__M00249WT1 (directAnnotation).
B2Mcisbp__M00839FOXP1 (directAnnotation).
B2Mtransfac_pro__M06750ZNF510 (directAnnotation).
B2Mmetacluster_139.9TFE3 (inferredBy_Orthology).
B2Mtransfac_pro__M04912FOXA1 (directAnnotation).
B2Mmetacluster_108.2ZNF286A (directAnnotation).
B2Mtransfac_pro__M05357POU4F2 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
B2M"3-Indolebutyric Acid"

DB02740

small molecule
B2M"Copper"

DB09130

small molecule
B2M"N-Formylmethionine"

DB04464

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."