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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATXN3

Summary for ATXN3

Gene information	Gene symbol	ATXN3
	Ensembl ID	ENSG00000066427
	Entrez ID	4287
	Gene name	ataxin 3
	Synonyms	ATX3\|JOS\|MJD\|SCA3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ATXN3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.2503	9.17e-18

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Expression of ATXN3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATXN3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATXN3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATXN3	hsa-miR-5011-5p	99.9254	NM_001164779
ATXN3	hsa-miR-190a-3p	99.4849	NM_001164779
ATXN3	hsa-miR-153-5p	99.1499	NM_001164779
ATXN3	hsa-miR-3148	98.4372	NM_001164779
ATXN3	hsa-miR-607	98.3381	NM_001164778
ATXN3	hsa-miR-4262	98.031	NM_001164776
ATXN3	hsa-miR-3613-3p	97.7771	NM_001164779
ATXN3	hsa-miR-10527-5p	97.5582	NM_001164776
ATXN3	hsa-miR-548c-3p	96.4667	NM_001164776
ATXN3	hsa-miR-12133	95.5076	NM_001164776
ATXN3	hsa-miR-1271-5p	95.5076	NM_001164776
ATXN3	hsa-miR-96-5p	95.0222	NM_001164776
ATXN3	hsa-miR-3145-3p	94.8234	NM_001164779
ATXN3	hsa-miR-181d-5p	94.2035	NM_001164776
ATXN3	hsa-miR-181b-5p	94.2035	NM_001164776
ATXN3	hsa-miR-181c-5p	94.2035	NM_001164776
ATXN3	hsa-miR-181a-5p	94.2035	NM_001164776
ATXN3	hsa-miR-548ar-3p	93.5786	NM_001164779
ATXN3	hsa-miR-3688-3p	93.4212	NM_001164776
ATXN3	hsa-miR-548a-3p	93.1092	NM_001164779
ATXN3	hsa-miR-548e-3p	93.1092	NM_001164779
ATXN3	hsa-miR-548bc	93.1092	NM_001164779
ATXN3	hsa-miR-548az-3p	93.1092	NM_001164779
ATXN3	hsa-miR-548f-3p	93.1092	NM_001164779
ATXN3	hsa-miR-3926	92.8117	NM_001164776
ATXN3	hsa-miR-92b-3p	92.3353	NM_001164776
ATXN3	hsa-miR-92a-3p	92.3353	NM_001164776
ATXN3	hsa-miR-32-5p	92.3353	NM_001164776
ATXN3	hsa-miR-670-5p	92.1859	NM_001164776
ATXN3	hsa-miR-367-3p	91.413	NM_001164776
ATXN3	hsa-miR-363-3p	91.413	NM_001164776
ATXN3	hsa-miR-25-3p	91.413	NM_001164776
ATXN3	hsa-miR-4775	91.2357	NM_001164779
ATXN3	hsa-miR-4422	90.6187	NM_001164776
ATXN3	hsa-miR-561-3p	90.0579	NM_001164779
ATXN3	hsa-miR-9718	89.6206	NM_001164779
ATXN3	hsa-miR-548at-5p	89.5146	NM_001164779
ATXN3	hsa-miR-4642	89.175	NM_001164776
ATXN3	hsa-miR-1185-1-3p	89.1293	NM_001164776
ATXN3	hsa-miR-1185-2-3p	89.1293	NM_001164776
ATXN3	hsa-miR-619-5p	89.0578	NM_001164779
ATXN3	hsa-miR-5692a	88.9838	NM_001164776
ATXN3	hsa-miR-6827-3p	88.5589	NM_001164779
ATXN3	hsa-miR-6867-5p	88.5169	NM_001164776
ATXN3	hsa-miR-6835-3p	87.3363	NM_001164776
ATXN3	hsa-miR-3617-5p	87.3349	NM_001164776
ATXN3	hsa-miR-641	87.3349	NM_001164776
ATXN3	hsa-miR-616-5p	87.3258	NM_001164779
ATXN3	hsa-miR-373-5p	87.3258	NM_001164779
ATXN3	hsa-miR-371b-5p	87.3258	NM_001164779

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Motifs and transcription factors (TFs) regulating ATXN3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATXN3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ATXN3	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ATXN3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ATXN3	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ATXN3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ATXN3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATXN3	cisbp__M00249	WT1 (directAnnotation).
ATXN3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ATXN3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ATXN3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ATXN3	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."