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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATXN2L

Summary for ATXN2L

Gene information	Gene symbol	ATXN2L
	Ensembl ID	ENSG00000168488
	Entrez ID	11273
	Gene name	ataxin 2 like
	Synonyms	A2D\|A2lp
	Gene type	protein_coding
	UniProtAcc	Q8WWM7

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Dataset with differentially expressed gene: ATXN2L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.64198	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.422183	2.31e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.431857	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.401281	0.00e+00

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Expression of ATXN2L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATXN2L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATXN2L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATXN2L	hsa-miR-6785-5p	99.3832	NM_148414
ATXN2L	hsa-miR-4728-5p	99.3832	NM_148414
ATXN2L	hsa-miR-149-3p	99.1797	NM_148414
ATXN2L	hsa-miR-6883-5p	99.1797	NM_148414
ATXN2L	hsa-miR-6739-5p	97.8844	NM_007245
ATXN2L	hsa-miR-6733-5p	96.784	NM_007245
ATXN2L	hsa-miR-380-3p	95.3749	NM_145714
ATXN2L	hsa-miR-3153	94.6543	NM_007245
ATXN2L	hsa-miR-5692a	93.1076	NM_145714
ATXN2L	hsa-miR-2054	92.5849	NM_145714
ATXN2L	hsa-miR-4761-5p	91.8264	NM_007245
ATXN2L	hsa-miR-12136	91.5374	NM_145714
ATXN2L	hsa-miR-12125	91.4539	NM_145714
ATXN2L	hsa-miR-6797-5p	91.343	NM_007245
ATXN2L	hsa-miR-1249-5p	91.343	NM_007245
ATXN2L	hsa-miR-203b-3p	89.5239	NM_007245
ATXN2L	hsa-miR-4731-5p	89.2298	NM_148414
ATXN2L	hsa-miR-548n	89.0726	NM_145714
ATXN2L	hsa-miR-3692-5p	87.4491	NM_007245
ATXN2L	hsa-miR-3120-5p	87.4133	NM_007245
ATXN2L	hsa-miR-6825-5p	86.4814	NM_007245
ATXN2L	hsa-miR-7106-5p	86.2106	NM_148414
ATXN2L	hsa-miR-4282	84.4638	NM_145714
ATXN2L	hsa-miR-6799-5p	83.8631	NM_148414
ATXN2L	hsa-miR-625-5p	83.076	NM_145714

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Motifs and transcription factors (TFs) regulating ATXN2L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATXN2L	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ATXN2L	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ATXN2L	transfac_pro__M06071	ZNF814 (directAnnotation).
ATXN2L	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ATXN2L	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ATXN2L	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ATXN2L	transfac_pro__M04950	EGR1 (directAnnotation).
ATXN2L	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ATXN2L	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ATXN2L	transfac_pro__M00652	NRF1 (directAnnotation).
ATXN2L	transfac_pro__M04866	HDAC2 (directAnnotation).
ATXN2L	jaspar__MA1122.1	TFDP1 (directAnnotation).
ATXN2L	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ATXN2L	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ATXN2L	jaspar__MA0502.2	NFYB (directAnnotation).
ATXN2L	metacluster_144.12	ZNF419; ZNF773 (directAnnotation).
ATXN2L	transfac_pro__M02090	E2F4 (directAnnotation).
ATXN2L	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."