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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATRN

Summary for ATRN

Gene information	Gene symbol	ATRN
	Ensembl ID	ENSG00000088812
	Entrez ID	8455
	Gene name	attractin
	Synonyms	DPPT-L\|MGCA
	Gene type	protein_coding
	UniProtAcc	O75882

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Dataset with differentially expressed gene: ATRN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.50971	1.64e-03

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Expression of ATRN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATRN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATRN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATRN	hsa-miR-6508-5p	98.7358	NM_139321
ATRN	hsa-miR-8067	98.6283	NM_139321
ATRN	hsa-miR-6077	98.1921	NM_139321
ATRN	hsa-miR-5688	97.813	NM_139321
ATRN	hsa-miR-4699-3p	97.5159	NM_139321
ATRN	hsa-miR-205-3p	97.3946	NM_139321
ATRN	hsa-miR-495-3p	97.0778	NM_139321
ATRN	hsa-miR-3663-3p	95.7958	NM_139321
ATRN	hsa-miR-138-1-3p	95.3153	NM_139321
ATRN	hsa-miR-6867-5p	94.4548	NM_139321
ATRN	hsa-miR-5582-5p	94.4157	NM_139321
ATRN	hsa-miR-5579-3p	94.2221	NM_139321
ATRN	hsa-miR-5571-5p	93.8017	NM_139321
ATRN	hsa-miR-5010-3p	93.7786	NM_139321
ATRN	hsa-miR-338-5p	93.671	NM_139321
ATRN	hsa-miR-4308	93.1582	NM_139321
ATRN	hsa-miR-3924	93.0346	NM_139321
ATRN	hsa-miR-1910-5p	92.748	NM_139321
ATRN	hsa-miR-4255	92.2052	NM_139321
ATRN	hsa-miR-492	92.037	NM_139321
ATRN	hsa-miR-1245b-3p	91.9708	NM_139321
ATRN	hsa-miR-29c-3p	91.1481	NM_139321
ATRN	hsa-miR-29a-3p	91.1481	NM_139321
ATRN	hsa-miR-29b-3p	91.1481	NM_139321
ATRN	hsa-miR-4423-3p	90.9572	NM_139321
ATRN	hsa-miR-627-3p	90.2719	NM_139321
ATRN	hsa-miR-548x-5p	89.9103	NM_139321
ATRN	hsa-miR-548f-5p	89.9103	NM_139321
ATRN	hsa-miR-548aj-5p	89.9103	NM_139321
ATRN	hsa-miR-548g-5p	89.9103	NM_139321
ATRN	hsa-miR-507	89.4598	NM_139321
ATRN	hsa-miR-5580-3p	89.1015	NM_139322
ATRN	hsa-miR-4438	88.8797	NM_139321
ATRN	hsa-miR-452-3p	88.6019	NM_139321
ATRN	hsa-miR-6752-3p	88.4531	NM_139321
ATRN	hsa-miR-4759	88.3659	NM_139321
ATRN	hsa-miR-3622a-5p	88.2295	NM_139321
ATRN	hsa-miR-183-5p	88.1742	NM_139321
ATRN	hsa-miR-10397-5p	87.8062	NM_139321
ATRN	hsa-miR-4711-5p	87.4641	NM_139321
ATRN	hsa-miR-5009-3p	87.4525	NM_139321
ATRN	hsa-miR-30d-3p	87.1174	NM_139321
ATRN	hsa-miR-30a-3p	87.1174	NM_139321
ATRN	hsa-miR-30e-3p	87.1174	NM_139321
ATRN	hsa-miR-5003-3p	86.8064	NM_139321
ATRN	hsa-miR-6783-3p	86.8001	NM_139321
ATRN	hsa-miR-6081	86.6837	NM_139321
ATRN	hsa-miR-6828-3p	86.4314	NM_139321
ATRN	hsa-miR-2681-5p	86.2357	NM_139321
ATRN	hsa-miR-557	85.9732	NM_139321

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Motifs and transcription factors (TFs) regulating ATRN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATRN	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."