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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATP8B1

Summary for ATP8B1

Gene information	Gene symbol	ATP8B1
	Ensembl ID	ENSG00000081923
	Entrez ID	5205
	Gene name	ATPase phospholipid transporting 8B1
	Synonyms	ATPIC\|BRIC\|FIC1\|PFIC\|PFIC1
	Gene type	protein_coding
	UniProtAcc	O43520

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Dataset with differentially expressed gene: ATP8B1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.37286	0.00e+00

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Expression of ATP8B1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP8B1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP8B1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP8B1	hsa-miR-4795-3p	97.6688	NM_005603
ATP8B1	hsa-miR-8083	95.9278	NM_005603
ATP8B1	hsa-miR-126-5p	95.5955	NM_005603
ATP8B1	hsa-miR-188-3p	92.9006	NM_005603
ATP8B1	hsa-miR-3686	92.8636	NM_005603
ATP8B1	hsa-miR-3121-3p	92.0195	NM_005603
ATP8B1	hsa-miR-651-3p	90.3953	NM_005603
ATP8B1	hsa-miR-4789-5p	90.3419	NM_005603
ATP8B1	hsa-miR-153-5p	89.9436	NM_005603
ATP8B1	hsa-miR-4330	88.8751	NM_005603
ATP8B1	hsa-miR-5701	88.0376	NM_005603
ATP8B1	hsa-miR-514b-3p	88.0334	NM_005603
ATP8B1	hsa-miR-514a-3p	88.0334	NM_005603
ATP8B1	hsa-miR-340-5p	87.9225	NM_005603
ATP8B1	hsa-miR-6838-3p	87.6153	NM_005603
ATP8B1	hsa-miR-548aw	86.6973	NM_005603
ATP8B1	hsa-miR-204-5p	86.4628	NM_005603
ATP8B1	hsa-miR-211-5p	86.4628	NM_005603
ATP8B1	hsa-miR-5003-3p	86.2475	NM_005603
ATP8B1	hsa-miR-875-3p	86.0349	NM_005603
ATP8B1	hsa-miR-4646-5p	85.6596	NM_005603
ATP8B1	hsa-miR-590-3p	85.5924	NM_005603
ATP8B1	hsa-miR-487a-3p	84.3296	NM_005603
ATP8B1	hsa-miR-154-3p	84.3296	NM_005603
ATP8B1	hsa-miR-642b-3p	84.2728	NM_005603
ATP8B1	hsa-miR-642a-3p	84.2728	NM_005603
ATP8B1	hsa-miR-6830-3p	83.8886	NM_005603
ATP8B1	hsa-miR-587	83.112	NM_005603
ATP8B1	hsa-miR-5685	81.6665	NM_005603
ATP8B1	hsa-miR-4690-3p	81.6665	NM_005603
ATP8B1	hsa-miR-4451	81.654	NM_005603
ATP8B1	hsa-miR-6814-5p	80.8891	NM_005603
ATP8B1	hsa-miR-204-3p	80.7006	NM_005603
ATP8B1	hsa-miR-4328	80.3415	NM_005603
ATP8B1	hsa-miR-1231	80.0382	NM_005603

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Motifs and transcription factors (TFs) regulating ATP8B1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP8B1	metacluster_135.11	NR2C2 (directAnnotation).
ATP8B1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ATP8B1	tfdimers__MD00038	TFAP2C (directAnnotation).
ATP8B1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ATP8B1	metacluster_7.13	ZFX (directAnnotation).
ATP8B1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ATP8B1	cisbp__M00968	MTF2 (directAnnotation).
ATP8B1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ATP8B1	cisbp__M00341	PAX6 (directAnnotation).
ATP8B1	metacluster_198.3	ZFP64 (directAnnotation).
ATP8B1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ATP8B1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ATP8B1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ATP8B1	cisbp__M00788	ZFY (inferredBy_Orthology).
ATP8B1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ATP8B1	metacluster_175.1	ZNF283 (directAnnotation).
ATP8B1	hdpi__ZNF304	ZNF304 (directAnnotation).
ATP8B1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ATP8B1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ATP8B1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ATP8B1	transfac_pro__M01199	TRIM28 (directAnnotation).
ATP8B1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ATP8B1	metacluster_151.2	ZNF23 (directAnnotation).
ATP8B1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ATP8B1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATP8B1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ATP8B1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."