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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ATP6V1C1

Summary for ATP6V1C1

Gene information	Gene symbol	ATP6V1C1
	Ensembl ID	ENSG00000155097
	Entrez ID	528
	Gene name	ATPase H+ transporting V1 subunit C1
	Synonyms	ATP6C\|ATP6D\|VATC\|Vma5
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ATP6V1C1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.47905	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.319132	4.85e-16

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Expression of ATP6V1C1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP6V1C1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP6V1C1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP6V1C1	hsa-miR-5011-5p	99.6051	NM_001695
ATP6V1C1	hsa-miR-29a-5p	97.9412	NM_001695
ATP6V1C1	hsa-miR-934	96.1135	NM_001695
ATP6V1C1	hsa-miR-6867-5p	96.0421	NM_001695
ATP6V1C1	hsa-miR-4709-5p	95.7819	NM_001695
ATP6V1C1	hsa-miR-144-5p	95.3328	NM_001695
ATP6V1C1	hsa-miR-519c-3p	93.6527	NM_001695
ATP6V1C1	hsa-miR-519b-3p	93.6527	NM_001695
ATP6V1C1	hsa-miR-519a-3p	93.6527	NM_001695
ATP6V1C1	hsa-miR-12136	93.4405	NM_001695
ATP6V1C1	hsa-miR-95-5p	93.0256	NM_001695
ATP6V1C1	hsa-miR-6833-3p	91.1686	NM_001695
ATP6V1C1	hsa-miR-4768-5p	89.0664	NM_001695
ATP6V1C1	hsa-miR-3146	87.1099	NM_001695
ATP6V1C1	hsa-miR-5692a	86.6988	NM_001695
ATP6V1C1	hsa-miR-7844-5p	86.2738	NM_001695
ATP6V1C1	hsa-miR-3121-5p	85.3824	NM_001695
ATP6V1C1	hsa-miR-4255	84.7322	NM_001695
ATP6V1C1	hsa-miR-8077	83.1903	NM_001695
ATP6V1C1	hsa-miR-4753-3p	83.1455	NM_001695
ATP6V1C1	hsa-miR-134-3p	82.8901	NM_001695
ATP6V1C1	hsa-miR-3618	82.1993	NM_001695
ATP6V1C1	hsa-miR-10527-5p	81.7833	NM_001695
ATP6V1C1	hsa-miR-510-3p	81.2937	NM_001695
ATP6V1C1	hsa-miR-190a-3p	80.3272	NM_001695
ATP6V1C1	hsa-miR-3158-5p	80.0079	NM_001695

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Motifs and transcription factors (TFs) regulating ATP6V1C1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP6V1C1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ATP6V1C1	jaspar__MA1483.2	ELF2 (directAnnotation).
ATP6V1C1	transfac_pro__M04826	EP300 (directAnnotation).
ATP6V1C1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ATP6V1C1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ATP6V1C1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ATP6V1C1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ATP6V1C1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ATP6V1C1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
ATP6V1C1	cisbp__M02645	ETS1 (directAnnotation).
ATP6V1C1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
ATP6V1C1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
ATP6V1C1	hdpi__ELF2	ELF2 (directAnnotation).
ATP6V1C1	metacluster_183.4	ETS1 (inferredBy_Orthology).
ATP6V1C1	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ATP6V1C1	"D-tartaric acid"	DB01694	small molecule
ATP6V1C1	"Thonzonium"	DB09552	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."