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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ATP2C1

Summary for ATP2C1

Gene information	Gene symbol	ATP2C1
	Ensembl ID	ENSG00000017260
	Entrez ID	27032
	Gene name	ATPase secretory pathway Ca2+ transporting 1
	Synonyms	ATP2C1A\|BCPM\|KIAA1347\|PMR1\|SPCA1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ATP2C1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.308598	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.384954	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.342827	1.31e-30

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Expression of ATP2C1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP2C1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP2C1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP2C1	hsa-miR-153-5p	99.396	NM_001199184
ATP2C1	hsa-miR-4705	99.0969	NM_001199184
ATP2C1	hsa-miR-4311	95.9791	NM_001001487
ATP2C1	hsa-miR-12128	95.3372	NM_001001487
ATP2C1	hsa-miR-3123	95.2302	NM_001001487
ATP2C1	hsa-miR-6853-3p	95.1752	NM_001199184
ATP2C1	hsa-miR-4662a-3p	94.9994	NM_001199184
ATP2C1	hsa-miR-1914-5p	94.3502	NM_001199184
ATP2C1	hsa-miR-302b-5p	93.143	NM_001199184
ATP2C1	hsa-miR-302d-5p	93.143	NM_001199184
ATP2C1	hsa-miR-6886-3p	92.9468	NM_001199184
ATP2C1	hsa-miR-519b-3p	92.744	NM_001199184
ATP2C1	hsa-miR-519a-3p	92.744	NM_001199184
ATP2C1	hsa-miR-519c-3p	92.744	NM_001199184
ATP2C1	hsa-miR-3682-5p	92.6544	NM_001199184
ATP2C1	hsa-miR-6830-5p	92.318	NM_001199184
ATP2C1	hsa-miR-590-3p	92.0992	NM_001199184
ATP2C1	hsa-miR-338-5p	91.8394	NM_001199184
ATP2C1	hsa-miR-224-5p	91.1089	NM_001199184
ATP2C1	hsa-miR-203a-3p	90.9368	NM_001199184
ATP2C1	hsa-miR-194-5p	90.4148	NM_001199184
ATP2C1	hsa-miR-302c-5p	89.9982	NM_001199184
ATP2C1	hsa-miR-579-3p	89.902	NM_001199184
ATP2C1	hsa-miR-664b-3p	89.902	NM_001199184
ATP2C1	hsa-miR-450b-5p	89.6115	NM_001199184
ATP2C1	hsa-miR-5582-5p	89.039	NM_001199184
ATP2C1	hsa-miR-495-5p	88.6501	NM_001199184
ATP2C1	hsa-miR-223-5p	88.4061	NM_001199184
ATP2C1	hsa-miR-3143	88.1964	NM_001199184
ATP2C1	hsa-miR-195-3p	87.8903	NM_001199184
ATP2C1	hsa-miR-16-2-3p	87.8903	NM_001199184
ATP2C1	hsa-miR-298	87.8521	NM_001199184
ATP2C1	hsa-miR-4793-5p	87.3927	NM_001199184
ATP2C1	hsa-miR-7975	87.3433	NM_001199184
ATP2C1	hsa-miR-155-5p	86.9787	NM_001199184
ATP2C1	hsa-miR-19a-3p	86.1334	NM_001199184
ATP2C1	hsa-miR-19b-3p	86.1334	NM_001199184
ATP2C1	hsa-miR-4777-3p	86.0813	NM_001199184
ATP2C1	hsa-miR-1273h-3p	85.2505	NM_001001487
ATP2C1	hsa-miR-548c-3p	84.3476	NM_001199184
ATP2C1	hsa-miR-302e	84.2546	NM_001199184
ATP2C1	hsa-miR-105-5p	84.2032	NM_001001487
ATP2C1	hsa-miR-7853-5p	84.2032	NM_001001487
ATP2C1	hsa-miR-938	83.2489	NM_001199184
ATP2C1	hsa-miR-3925-5p	83.1103	NM_001001487
ATP2C1	hsa-miR-494-3p	82.6967	NM_001199184
ATP2C1	hsa-miR-1264	81.3262	NM_001199184
ATP2C1	hsa-miR-888-5p	81.0472	NM_001199184
ATP2C1	hsa-miR-3941	81.0298	NM_001199184
ATP2C1	hsa-miR-5088-3p	80.6557	NM_001199184

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Motifs and transcription factors (TFs) regulating ATP2C1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP2C1	metacluster_7.13	ZFX (directAnnotation).
ATP2C1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ATP2C1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ATP2C1	jaspar__MA1483.2	ELF2 (directAnnotation).
ATP2C1	metacluster_151.2	ZNF23 (directAnnotation).
ATP2C1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ATP2C1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ATP2C1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ATP2C1	hdpi__ETV4	ETV4 (directAnnotation).
ATP2C1	transfac_pro__M06071	ZNF814 (directAnnotation).
ATP2C1	transfac_pro__M05628	ZNF735 (directAnnotation).
ATP2C1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ATP2C1	jaspar__MA1933.1	SREBF2 (directAnnotation).
ATP2C1	jaspar__MA0079.5	SP1 (directAnnotation).
ATP2C1	transfac_pro__M04826	EP300 (directAnnotation).
ATP2C1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ATP2C1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ATP2C1	transfac_pro__M04950	EGR1 (directAnnotation).
ATP2C1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ATP2C1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
ATP2C1	transfac_pro__M04866	HDAC2 (directAnnotation).
ATP2C1	jaspar__MA1122.1	TFDP1 (directAnnotation).
ATP2C1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ATP2C1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ATP2C1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ATP2C1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ATP2C1	cisbp__M00968	MTF2 (directAnnotation).
ATP2C1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ATP2C1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ATP2C1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ATP2C1	cisbp__M00788	ZFY (inferredBy_Orthology).
ATP2C1	hdpi__ZNF304	ZNF304 (directAnnotation).
ATP2C1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ATP2C1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ATP2C1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ATP2C1	transfac_pro__M01199	TRIM28 (directAnnotation).
ATP2C1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ATP2C1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ATP2C1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATP2C1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ATP2C1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ATP2C1	"Calcium"	DB01373	small molecule
ATP2C1	"Enflurane"	DB00228	small molecule
ATP2C1	"Isoflurane"	DB00753	small molecule
ATP2C1	"Methoxyflurane"	DB01028	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."