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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATP2B4

Summary for ATP2B4

Gene information	Gene symbol	ATP2B4
	Ensembl ID	ENSG00000058668
	Entrez ID	493
	Gene name	ATPase plasma membrane Ca2+ transporting 4
	Synonyms	ATP2B2\|MXRA1\|PMCA4
	Gene type	protein_coding
	UniProtAcc	P23634

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Dataset with differentially expressed gene: ATP2B4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.78924	8.56e-17
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.332948	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.409783	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.356254	0.00e+00

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Expression of ATP2B4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP2B4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP2B4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP2B4	hsa-miR-548b-3p	98.2646	NM_001684
ATP2B4	hsa-miR-548aa	97.9079	NM_001001396
ATP2B4	hsa-miR-548ap-3p	97.9079	NM_001001396
ATP2B4	hsa-miR-548t-3p	97.9079	NM_001001396
ATP2B4	hsa-miR-8068	97.5091	NM_001001396
ATP2B4	hsa-miR-3688-3p	97.0301	NM_001684
ATP2B4	hsa-miR-3663-5p	97.0138	NM_001001396
ATP2B4	hsa-miR-6845-3p	96.895	NM_001684
ATP2B4	hsa-miR-183-5p	96.7408	NM_001001396
ATP2B4	hsa-miR-877-3p	96.698	NM_001001396
ATP2B4	hsa-miR-3133	96.345	NM_001001396
ATP2B4	hsa-miR-5193	95.895	NM_001001396
ATP2B4	hsa-miR-889-5p	95.7846	NM_001001396
ATP2B4	hsa-miR-4747-5p	95.4945	NM_001684
ATP2B4	hsa-miR-5196-5p	95.4945	NM_001684
ATP2B4	hsa-miR-4668-5p	95.4494	NM_001684
ATP2B4	hsa-miR-3065-5p	93.2261	NM_001684
ATP2B4	hsa-miR-5011-5p	92.9869	NM_001001396
ATP2B4	hsa-miR-3919	92.9068	NM_001001396
ATP2B4	hsa-miR-4690-5p	91.675	NM_001684
ATP2B4	hsa-miR-5580-3p	91.5714	NM_001684
ATP2B4	hsa-miR-3175	91.0718	NM_001684
ATP2B4	hsa-miR-7162-3p	91.0464	NM_001001396
ATP2B4	hsa-miR-6516-5p	90.9265	NM_001684
ATP2B4	hsa-miR-498-3p	90.4527	NM_001001396
ATP2B4	hsa-miR-6757-5p	90.0927	NM_001684
ATP2B4	hsa-miR-4801	89.3876	NM_001684
ATP2B4	hsa-miR-4738-3p	89.1363	NM_001001396
ATP2B4	hsa-miR-29b-3p	88.5565	NM_001001396
ATP2B4	hsa-miR-29c-3p	88.5565	NM_001001396
ATP2B4	hsa-miR-29a-3p	88.5565	NM_001001396
ATP2B4	hsa-miR-96-5p	88.248	NM_001001396
ATP2B4	hsa-miR-6741-5p	88.2056	NM_001684
ATP2B4	hsa-miR-1271-5p	87.8773	NM_001001396
ATP2B4	hsa-miR-12133	87.8773	NM_001001396
ATP2B4	hsa-miR-545-3p	87.8222	NM_001684
ATP2B4	hsa-miR-27b-5p	87.6904	NM_001001396
ATP2B4	hsa-miR-3202	87.4676	NM_001684
ATP2B4	hsa-miR-6879-5p	86.8196	NM_001684
ATP2B4	hsa-miR-4632-5p	86.8196	NM_001684
ATP2B4	hsa-miR-6735-5p	86.8196	NM_001684
ATP2B4	hsa-miR-4436b-3p	86.8196	NM_001684
ATP2B4	hsa-miR-7843-5p	86.8196	NM_001684
ATP2B4	hsa-miR-767-5p	85.9856	NM_001001396
ATP2B4	hsa-miR-3150a-3p	85.6844	NM_001684
ATP2B4	hsa-miR-6763-5p	85.6844	NM_001684
ATP2B4	hsa-miR-548h-3p	85.3091	NM_001684
ATP2B4	hsa-miR-548ac	85.3091	NM_001684
ATP2B4	hsa-miR-548d-3p	85.3091	NM_001684
ATP2B4	hsa-miR-548bb-3p	85.3091	NM_001684

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Motifs and transcription factors (TFs) regulating ATP2B4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP2B4	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ATP2B4	transfac_pro__M03876	ZBTB33 (directAnnotation).
ATP2B4	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ATP2B4	jaspar__MA1483.2	ELF2 (directAnnotation).
ATP2B4	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
ATP2B4	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
ATP2B4	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
ATP2B4	taipale_tf_pairs__ERF_CEBPD_RSMGGAANTTGCGYAAN_CAP	CEBPD; ERF (directAnnotation).
ATP2B4	hdpi__GTF3C2	GTF3C2 (directAnnotation).
ATP2B4	transfac_pro__M07437	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."