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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATP2B1

Summary for ATP2B1

Gene information	Gene symbol	ATP2B1
	Ensembl ID	ENSG00000070961
	Entrez ID	490
	Gene name	ATPase plasma membrane Ca2+ transporting 1
	Synonyms	PMCA1
	Gene type	protein_coding
	UniProtAcc	P20020

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Dataset with differentially expressed gene: ATP2B1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.336377	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.325259	3.35e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.262035	1.04e-29
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.462619	1.05e-02
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.512833	1.59e-11
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.368829	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.406883	1.68e-20
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.339662	1.44e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.510743	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	0.415345	3.42e-16
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	1.18145	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-2.04324	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.337298	4.20e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.526201	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.648948	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.740484	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.335637	0.00e+00

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Expression of ATP2B1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP2B1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP2B1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP2B1	hsa-miR-4262	97.8758	NM_001001323
ATP2B1	hsa-miR-520d-5p	96.9019	NM_001682
ATP2B1	hsa-miR-524-5p	96.9019	NM_001682
ATP2B1	hsa-miR-181d-5p	96.412	NM_001001323
ATP2B1	hsa-miR-181a-5p	96.412	NM_001001323
ATP2B1	hsa-miR-181b-5p	96.412	NM_001001323
ATP2B1	hsa-miR-181c-5p	96.412	NM_001001323
ATP2B1	hsa-miR-330-3p	96.1359	NM_001001323
ATP2B1	hsa-miR-4311	95.8671	NM_001001323
ATP2B1	hsa-miR-1283	94.675	NM_001682
ATP2B1	hsa-miR-1252-3p	94.2852	NM_001682
ATP2B1	hsa-miR-6806-5p	93.877	NM_001682
ATP2B1	hsa-miR-219a-1-3p	93.7114	NM_001682
ATP2B1	hsa-miR-6733-3p	93.4254	NM_001001323
ATP2B1	hsa-miR-3613-3p	92.4005	NM_001682
ATP2B1	hsa-miR-548an	91.6072	NM_001001323
ATP2B1	hsa-miR-6884-3p	91.4087	NM_001001323
ATP2B1	hsa-miR-582-5p	91.3071	NM_001001323
ATP2B1	hsa-miR-759	91.2476	NM_001001323
ATP2B1	hsa-miR-4803	91.1924	NM_001001323
ATP2B1	hsa-miR-3658	90.7369	NM_001682
ATP2B1	hsa-miR-4711-5p	90.1742	NM_001001323
ATP2B1	hsa-miR-27b-3p	89.647	NM_001001323
ATP2B1	hsa-miR-27a-3p	89.647	NM_001001323
ATP2B1	hsa-miR-9985	89.647	NM_001001323
ATP2B1	hsa-miR-1323	89.5862	NM_001682
ATP2B1	hsa-miR-5692a	89.48	NM_001001323
ATP2B1	hsa-miR-4713-3p	89.2327	NM_001001323
ATP2B1	hsa-miR-1252-5p	88.5824	NM_001001323
ATP2B1	hsa-miR-20a-3p	88.3936	NM_001001323
ATP2B1	hsa-miR-144-3p	88.2238	NM_001682
ATP2B1	hsa-miR-6728-5p	87.7332	NM_001682
ATP2B1	hsa-miR-873-5p	87.4867	NM_001682
ATP2B1	hsa-miR-1246	87.2825	NM_001682
ATP2B1	hsa-miR-548o-3p	87.2547	NM_001682
ATP2B1	hsa-miR-4482-3p	87.021	NM_001001323
ATP2B1	hsa-miR-338-5p	87.0161	NM_001001323
ATP2B1	hsa-miR-520h	86.9769	NM_001001323
ATP2B1	hsa-miR-520g-3p	86.9769	NM_001001323
ATP2B1	hsa-miR-3667-5p	86.9288	NM_001682
ATP2B1	hsa-miR-4422	86.8633	NM_001001323
ATP2B1	hsa-miR-4282	86.5483	NM_001001323
ATP2B1	hsa-miR-5693	86.4995	NM_001682
ATP2B1	hsa-miR-6740-3p	86.43	NM_001682
ATP2B1	hsa-miR-877-5p	86.3559	NM_001682
ATP2B1	hsa-miR-6835-3p	85.9335	NM_001001323
ATP2B1	hsa-miR-544b	85.7256	NM_001001323
ATP2B1	hsa-miR-6837-5p	85.6724	NM_001001323
ATP2B1	hsa-miR-4685-5p	85.6724	NM_001001323
ATP2B1	hsa-miR-498-3p	85.5237	NM_001001323

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Motifs and transcription factors (TFs) regulating ATP2B1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP2B1	metacluster_52.5	HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2 (directAnnotation).
ATP2B1	metacluster_76.1	ZNF345; ZNF345 (directAnnotation). MYB; MYBL1 (inferredBy_Orthology).
ATP2B1	transfac_pro__M06180	ZNF445 (directAnnotation).
ATP2B1	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
ATP2B1	transfac_pro__M06764	ZNF112 (directAnnotation).
ATP2B1	transfac_pro__M06159	ZNF83 (directAnnotation).
ATP2B1	transfac_pro__M06317	ZNF829 (directAnnotation).
ATP2B1	transfac_pro__M04861	SIX5 (directAnnotation).
ATP2B1	metacluster_172.23	ZBTB32; ZBTB32 (directAnnotation).
ATP2B1	hdpi__FLI1	FLI1 (directAnnotation).
ATP2B1	jaspar__MA0502.2	NFYB (directAnnotation).
ATP2B1	metacluster_168.4	ZNF652 (directAnnotation).
ATP2B1	transfac_pro__M06550	ZNF519 (directAnnotation).
ATP2B1	jaspar__MA1956.1	FOXO1 (directAnnotation).
ATP2B1	jaspar__MA1954.1	FOXO1 (directAnnotation).
ATP2B1	jaspar__MA1946.1	FOXI1 (directAnnotation).
ATP2B1	jaspar__MA1955.1	FOXO1 (directAnnotation).
ATP2B1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
ATP2B1	tfdimers__MD00075	FOXO4; NANOG (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."