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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATP1B2

Summary for ATP1B2

Gene information	Gene symbol	ATP1B2
	Ensembl ID	ENSG00000129244
	Entrez ID	482
	Gene name	ATPase Na+/K+ transporting subunit beta 2
	Synonyms	AMOG
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ATP1B2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.345186	0.00e+00

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Expression of ATP1B2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP1B2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP1B2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP1B2	hsa-miR-4747-5p	96.5896	NM_001303263
ATP1B2	hsa-miR-5196-5p	96.5896	NM_001303263
ATP1B2	hsa-miR-5011-5p	95.2096	NM_001303263
ATP1B2	hsa-miR-190a-3p	95.1982	NM_001303263
ATP1B2	hsa-miR-6756-5p	94.325	NM_001303263
ATP1B2	hsa-miR-608	93.7509	NM_001303263
ATP1B2	hsa-miR-4651	93.7509	NM_001303263
ATP1B2	hsa-miR-2467-3p	93.1865	NM_001303263
ATP1B2	hsa-miR-1249-5p	92.6317	NM_001303263
ATP1B2	hsa-miR-4441	92.0329	NM_001303263
ATP1B2	hsa-miR-6769b-5p	91.696	NM_001303263
ATP1B2	hsa-miR-6769a-5p	90.9592	NM_001303263
ATP1B2	hsa-miR-6766-5p	90.7441	NM_001303263
ATP1B2	hsa-miR-6808-5p	90.5635	NM_001303263
ATP1B2	hsa-miR-6797-5p	90.5009	NM_001303263
ATP1B2	hsa-miR-940	89.8976	NM_001303263
ATP1B2	hsa-miR-892c-5p	89.4084	NM_001303263
ATP1B2	hsa-miR-4316	89.1501	NM_001303263
ATP1B2	hsa-miR-6893-5p	88.6926	NM_001303263
ATP1B2	hsa-miR-6867-5p	88.6899	NM_001303263
ATP1B2	hsa-miR-4270	88.2383	NM_001303263
ATP1B2	hsa-miR-2467-5p	87.8529	NM_001303263
ATP1B2	hsa-miR-6830-5p	87.6959	NM_001303263
ATP1B2	hsa-miR-6730-3p	87.5561	NM_001303263
ATP1B2	hsa-miR-6754-5p	87.0687	NM_001303263
ATP1B2	hsa-miR-3613-3p	86.1595	NM_001303263
ATP1B2	hsa-miR-4728-5p	86.0886	NM_001303263
ATP1B2	hsa-miR-4314	86.04	NM_001303263
ATP1B2	hsa-miR-7154-3p	85.0039	NM_001303263
ATP1B2	hsa-miR-4275	84.6587	NM_001303263
ATP1B2	hsa-miR-6758-5p	83.2844	NM_001303263
ATP1B2	hsa-miR-6878-5p	82.7255	NM_001303263
ATP1B2	hsa-miR-103a-3p	82.5747	NM_001303263
ATP1B2	hsa-miR-107	82.5747	NM_001303263
ATP1B2	hsa-miR-4692	82.4326	NM_001303263
ATP1B2	hsa-miR-4749-3p	81.9515	NM_001303263
ATP1B2	hsa-miR-505-5p	81.2153	NM_001303263
ATP1B2	hsa-miR-6856-5p	81.1657	NM_001303263
ATP1B2	hsa-miR-7157-5p	80.5138	NM_001303263
ATP1B2	hsa-miR-6133	80.4501	NM_001303263
ATP1B2	hsa-miR-4510	80.4501	NM_001303263
ATP1B2	hsa-miR-6129	80.4501	NM_001303263
ATP1B2	hsa-miR-6130	80.4501	NM_001303263
ATP1B2	hsa-miR-6127	80.4501	NM_001303263
ATP1B2	hsa-miR-6847-5p	80.2336	NM_001303263

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Motifs and transcription factors (TFs) regulating ATP1B2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP1B2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."