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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATP13A2

Summary for ATP13A2

Gene information	Gene symbol	ATP13A2
	Ensembl ID	ENSG00000159363
	Entrez ID	23400
	Gene name	ATPase cation transporting 13A2
	Synonyms	CLN12\|HSA9947\|PARK9
	Gene type	protein_coding
	UniProtAcc	Q9NQ11

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Dataset with differentially expressed gene: ATP13A2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.753623	1.07e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.329792	7.91e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.524921	0.00e+00

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Expression of ATP13A2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP13A2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP13A2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP13A2	hsa-miR-199a-5p	87.997	NM_001141973
ATP13A2	hsa-miR-199b-5p	87.997	NM_001141973
ATP13A2	hsa-miR-24-3p	87.9383	NM_022089
ATP13A2	hsa-miR-1233-5p	82.5349	NM_022089
ATP13A2	hsa-miR-6778-5p	82.5349	NM_022089

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Motifs and transcription factors (TFs) regulating ATP13A2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP13A2	transfac_pro__M06839	ZNF263 (inferredBy_Orthology).
ATP13A2	tfdimers__MD00550	PITX3; TEAD1 (directAnnotation).
ATP13A2	transfac_pro__M06568	ZNF501 (directAnnotation).
ATP13A2	tfdimers__MD00208	IRF1; LTF (directAnnotation).
ATP13A2	transfac_pro__M06795	ZNF780B (directAnnotation).
ATP13A2	transfac_pro__M06252	ZNF415 (directAnnotation).
ATP13A2	transfac_pro__M06153	ZNF83 (directAnnotation).
ATP13A2	taipale_tf_pairs__TEAD4_SPDEF_RGWATSCGGATGNNNNTCCKNNN_CAP_repr	SPDEF; TEAD4 (directAnnotation).
ATP13A2	kznf__ZNF736_Imbeault2017_OM_RCADE	ZNF736 (directAnnotation).
ATP13A2	tfdimers__MD00502	PBX1; SOX9 (directAnnotation).
ATP13A2	tfdimers__MD00599	NR1I2; RXRA; STAT1 (directAnnotation).
ATP13A2	taipale_tf_pairs__TEAD4_HOXA13_RCATWCCNNNNNNNNYNNTAAA_CAP_repr	HOXA13; TEAD4 (directAnnotation).
ATP13A2	transfac_pro__M06127	ZSCAN22 (directAnnotation).
ATP13A2	transfac_pro__M04906	SIN3A (directAnnotation).
ATP13A2	transfac_pro__M05827	ZNF544 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."