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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATP11A

Summary for ATP11A

Gene information	Gene symbol	ATP11A
	Ensembl ID	ENSG00000068650
	Entrez ID	23250
	Gene name	ATPase phospholipid transporting 11A
	Synonyms	ATPIH\|ATPIS\|KIAA1021
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ATP11A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.31499	9.95e-18
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-0.350965	5.65e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.440141	1.98e-22
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.299793	1.30e-28

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Expression of ATP11A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP11A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP11A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP11A	hsa-miR-6867-5p	99.9951	NM_032189
ATP11A	hsa-miR-1207-5p	99.4907	NM_032189
ATP11A	hsa-miR-323a-3p	99.1694	NM_032189
ATP11A	hsa-miR-4763-3p	99.0714	NM_032189
ATP11A	hsa-miR-4455	97.8868	NM_015205
ATP11A	hsa-miR-3191-3p	96.4591	NM_032189
ATP11A	hsa-miR-6893-3p	95.7986	NM_015205
ATP11A	hsa-miR-7856-5p	95.7752	NM_015205
ATP11A	hsa-miR-370-3p	95.774	NM_015205
ATP11A	hsa-miR-544a	95.6827	NM_032189
ATP11A	hsa-miR-9-3p	95.3631	NM_015205
ATP11A	hsa-miR-3671	94.572	NM_015205
ATP11A	hsa-miR-148b-3p	93.3553	NM_015205
ATP11A	hsa-miR-148a-3p	93.3553	NM_015205
ATP11A	hsa-miR-152-3p	93.3553	NM_015205
ATP11A	hsa-miR-216b-3p	92.7051	NM_032189
ATP11A	hsa-miR-4477b	91.6232	NM_015205
ATP11A	hsa-miR-590-3p	91.3845	NM_032189
ATP11A	hsa-miR-4722-5p	91.0325	NM_032189
ATP11A	hsa-miR-7152-5p	90.9908	NM_032189
ATP11A	hsa-miR-548at-5p	90.7928	NM_032189
ATP11A	hsa-miR-3123	89.7295	NM_032189
ATP11A	hsa-miR-3926	89.6554	NM_015205
ATP11A	hsa-miR-549a-3p	89.5128	NM_032189
ATP11A	hsa-miR-1976	88.8115	NM_032189
ATP11A	hsa-miR-3646	87.3794	NM_032189
ATP11A	hsa-miR-559	87.2764	NM_032189
ATP11A	hsa-miR-548f-5p	87.2076	NM_032189
ATP11A	hsa-miR-9-5p	87.1607	NM_015205
ATP11A	hsa-miR-548ad-5p	86.9155	NM_032189
ATP11A	hsa-miR-548am-5p	86.9155	NM_032189
ATP11A	hsa-miR-548a-5p	86.9155	NM_032189
ATP11A	hsa-miR-548o-5p	86.9155	NM_032189
ATP11A	hsa-miR-548bb-5p	86.9155	NM_032189
ATP11A	hsa-miR-548h-5p	86.9155	NM_032189
ATP11A	hsa-miR-548as-5p	86.9155	NM_032189
ATP11A	hsa-miR-548w	86.9155	NM_032189
ATP11A	hsa-miR-548b-5p	86.9155	NM_032189
ATP11A	hsa-miR-548ae-5p	86.9155	NM_032189
ATP11A	hsa-miR-548d-5p	86.9155	NM_032189
ATP11A	hsa-miR-548j-5p	86.9155	NM_032189
ATP11A	hsa-miR-548i	86.9155	NM_032189
ATP11A	hsa-miR-548ay-5p	86.9155	NM_032189
ATP11A	hsa-miR-548aq-5p	86.9155	NM_032189
ATP11A	hsa-miR-548ar-5p	86.9155	NM_032189
ATP11A	hsa-miR-548au-5p	86.9155	NM_032189
ATP11A	hsa-miR-548ap-5p	86.9155	NM_032189
ATP11A	hsa-miR-548c-5p	86.9155	NM_032189
ATP11A	hsa-miR-548ab	86.9155	NM_032189
ATP11A	hsa-miR-548y	86.9155	NM_032189

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Motifs and transcription factors (TFs) regulating ATP11A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP11A	tfdimers__MD00292	HLTF; POU5F1 (directAnnotation).
ATP11A	transfac_pro__M07604	MECOM; RUNX1 (directAnnotation).
ATP11A	taipale_tf_pairs__ETV2_EVX1_RSCGGWAATNNNYATTAN_CAP	ETV2; EVX1 (directAnnotation).
ATP11A	tfdimers__MD00313	ING4; NFATC4 (directAnnotation).
ATP11A	transfac_pro__M01877	GATA2 (directAnnotation).
ATP11A	kznf__ZNF33A_Najafabadi2015_ChIP-seq	ZNF33A (directAnnotation).
ATP11A	tfdimers__MD00107	HOXA13; TFAP2C (directAnnotation).
ATP11A	metacluster_165.3	HOMEZ; HOMEZ; HOMEZ (directAnnotation).
ATP11A	cisbp__M00273	CRX (directAnnotation).
ATP11A	transfac_pro__M02919	HNF1A (inferredBy_Orthology).
ATP11A	swissregulon__hs__DBP	DBP (directAnnotation).
ATP11A	transfac_pro__M07607	NFATC3 (directAnnotation).
ATP11A	tfdimers__MD00465	CRX; IKZF1 (directAnnotation).
ATP11A	jaspar__MA1483.2	ELF2 (directAnnotation).
ATP11A	hdpi__ETV4	ETV4 (directAnnotation).
ATP11A	transfac_pro__M04862	NRF1 (directAnnotation).
ATP11A	transfac_pro__M06173	ZNF85 (directAnnotation).
ATP11A	transfac_pro__M04950	EGR1 (directAnnotation).
ATP11A	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
ATP11A	taipale_tf_pairs__HOXB2_PAX1_NNMATTAGTCACGCWTSRNTG_CAP_repr	HOXB2; PAX1 (directAnnotation).
ATP11A	transfac_pro__M06135	ZNF28 (directAnnotation).
ATP11A	taipale_tf_pairs__HOXB2_PAX9_NNMATTAGTCACGCWTSRNTG_CAP	HOXB2; PAX9 (directAnnotation).
ATP11A	transfac_pro__M03806	ZBTB7C (directAnnotation).
ATP11A	tfdimers__MD00483	ZBTB14 (directAnnotation).
ATP11A	transfac_pro__M06085	ZNF26 (directAnnotation).
ATP11A	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
ATP11A	tfdimers__MD00364	WT1 (directAnnotation).
ATP11A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ATP11A	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ATP11A	transfac_pro__M01253	CNOT3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."