Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATL1

Summary for ATL1

Gene information	Gene symbol	ATL1
	Ensembl ID	ENSG00000198513
	Entrez ID	51062
	Gene name	atlastin GTPase 1
	Synonyms	AD-FSP\|FSP1\|SPG3\|SPG3A
	Gene type	protein_coding
	UniProtAcc	Q8WXF7

Top

Dataset with differentially expressed gene: ATL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.301927	0.00e+00

Top

Expression of ATL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ATL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ATL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATL1	hsa-miR-3689f	96.4534	NM_181598
ATL1	hsa-miR-3689b-5p	96.4534	NM_181598
ATL1	hsa-miR-3689a-5p	96.4534	NM_181598
ATL1	hsa-miR-3689e	96.4534	NM_181598
ATL1	hsa-miR-5011-5p	94.7766	NM_181598
ATL1	hsa-miR-6804-3p	94.2683	NM_001127713
ATL1	hsa-miR-141-3p	93.6227	NM_181598
ATL1	hsa-miR-2113	93.3205	NM_181598
ATL1	hsa-miR-200a-3p	92.9316	NM_181598
ATL1	hsa-miR-3914	91.6372	NM_181598
ATL1	hsa-miR-548ar-3p	91.4765	NM_181598
ATL1	hsa-miR-5011-3p	91.0191	NM_181598
ATL1	hsa-miR-4482-5p	90.1546	NM_001127713
ATL1	hsa-miR-3130-5p	90.1546	NM_001127713
ATL1	hsa-miR-218-5p	89.6271	NM_181598
ATL1	hsa-miR-548bc	85.8356	NM_181598
ATL1	hsa-miR-548a-3p	85.8356	NM_181598
ATL1	hsa-miR-548f-3p	85.8356	NM_181598
ATL1	hsa-miR-548e-3p	85.8356	NM_181598
ATL1	hsa-miR-548az-3p	85.8356	NM_181598
ATL1	hsa-miR-8066	84.3998	NM_181598
ATL1	hsa-miR-4262	83.4985	NM_001127713
ATL1	hsa-miR-500a-3p	82.9356	NM_001127713
ATL1	hsa-miR-98-3p	81.2149	NM_001127713
ATL1	hsa-let-7f-1-3p	81.2149	NM_001127713
ATL1	hsa-let-7b-3p	81.2149	NM_001127713
ATL1	hsa-let-7a-3p	81.2149	NM_001127713

Page: 1

Top

Motifs and transcription factors (TFs) regulating ATL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATL1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ATL1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATL1	transfac_pro__M07397	ZNF148 (directAnnotation).
ATL1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ATL1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ATL1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ATL1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ATL1	metacluster_7.13	ZFX (directAnnotation).
ATL1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ATL1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ATL1	transfac_pro__M01175	ZBTB7B (directAnnotation).
ATL1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ATL1	tfdimers__MD00151	CHURC1 (directAnnotation).
ATL1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ATL1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ATL1	transfac_pro__M01303	SP1 (directAnnotation).
ATL1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ATL1	transfac_pro__M01714	KLF15 (directAnnotation).
ATL1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ATL1	transfac_pro__M02089	E2F3 (directAnnotation).
ATL1	metacluster_3.14	WT1; WT1 (directAnnotation).
ATL1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ATL1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ATL1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ATL1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ATL1	transfac_pro__M07436	WT1 (directAnnotation).
ATL1	transfac_pro__M02281	SP1 (directAnnotation).
ATL1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ATL1	transfac_pro__M02898	SMAD3 (directAnnotation).
ATL1	transfac_public__M00491	PATZ1 (directAnnotation).
ATL1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."