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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATG5

Summary for ATG5

Gene information	Gene symbol	ATG5
	Ensembl ID	ENSG00000057663
	Entrez ID	9474
	Gene name	autophagy related 5
	Synonyms	APG5\|APG5L\|ASP\|hAPG5
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ATG5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.260745	4.20e-11
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.368421	2.89e-16
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.337699	2.04e-15
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.252975	7.42e-06

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Expression of ATG5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATG5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ATG5	Epigenetic Alteration of DNA, RNA or Protein
ATG5	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating ATG5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATG5	hsa-miR-605-5p	98.7865	NM_001286108
ATG5	hsa-miR-651-3p	97.6533	NM_001286108
ATG5	hsa-miR-12124	97.1866	NM_001286108
ATG5	hsa-miR-4775	96.4588	NM_004849
ATG5	hsa-miR-4742-5p	94.783	NM_004849
ATG5	hsa-miR-567	94.3016	NM_004849
ATG5	hsa-miR-4282	92.7885	NM_004849
ATG5	hsa-miR-629-5p	92.7675	NM_004849
ATG5	hsa-miR-6858-3p	91.9686	NM_001286108
ATG5	hsa-miR-4477b	91.181	NM_001286108
ATG5	hsa-miR-7851-3p	90.8258	NM_004849
ATG5	hsa-miR-133a-5p	90.514	NM_001286108
ATG5	hsa-miR-3133	89.9595	NM_001286108
ATG5	hsa-miR-3611	89.9463	NM_004849
ATG5	hsa-miR-2115-3p	89.4174	NM_004849
ATG5	hsa-miR-4533	88.7002	NM_001286108
ATG5	hsa-miR-30b-5p	88.5735	NM_001286108
ATG5	hsa-miR-30e-5p	88.5735	NM_001286108
ATG5	hsa-miR-30a-5p	88.5735	NM_001286108
ATG5	hsa-miR-30d-5p	88.5735	NM_001286108
ATG5	hsa-miR-30c-5p	88.5735	NM_001286108
ATG5	hsa-miR-153-5p	86.534	NM_004849
ATG5	hsa-miR-4329	86.1798	NM_001286108
ATG5	hsa-miR-6839-3p	83.8571	NM_004849
ATG5	hsa-miR-6809-3p	83.1131	NM_004849
ATG5	hsa-miR-448	82.2182	NM_001286108
ATG5	hsa-miR-153-3p	82.2182	NM_001286108
ATG5	hsa-miR-5702	81.6687	NM_004849
ATG5	hsa-miR-6074	81.5539	NM_004849
ATG5	hsa-miR-543	81.3826	NM_001286108
ATG5	hsa-miR-3646	81.2874	NM_001286108
ATG5	hsa-miR-548at-5p	80.9007	NM_001286108
ATG5	hsa-miR-4753-3p	80.8937	NM_004849
ATG5	hsa-miR-1178-3p	80.8932	NM_004849
ATG5	hsa-miR-34a-5p	80.7719	NM_001286108
ATG5	hsa-miR-449a	80.7719	NM_001286108
ATG5	hsa-miR-6853-3p	80.3854	NM_004849

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Motifs and transcription factors (TFs) regulating ATG5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATG5	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ATG5	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ATG5	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ATG5	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ATG5	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ATG5	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
ATG5	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ATG5	transfac_pro__M04826	EP300 (directAnnotation).
ATG5	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ATG5	swissregulon__hs__ELF2	ELF2 (directAnnotation).
ATG5	hdpi__ETV4	ETV4 (directAnnotation).
ATG5	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
ATG5	hdpi__FLI1	FLI1 (directAnnotation).
ATG5	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ATG5	hdpi__TP73	TP73 (directAnnotation).
ATG5	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
ATG5	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
ATG5	cisbp__M02645	ETS1 (directAnnotation).
ATG5	jaspar__MA1708.1	ETV7 (directAnnotation).
ATG5	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
ATG5	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
ATG5	hdpi__ELF2	ELF2 (directAnnotation).
ATG5	swissregulon__hs__ELK1	ELK1 (directAnnotation).
ATG5	metacluster_183.4	ETS1 (inferredBy_Orthology).
ATG5	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
ATG5	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
ATG5	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
ATG5	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ATG5	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
ATG5	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
ATG5	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ATG5	metacluster_81.7	CREB1 (directAnnotation).
ATG5	transfac_pro__M01298	MECP2 (directAnnotation).
ATG5	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ATG5	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
ATG5	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ATG5	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."

1	LncRNA MALAT1 potentiates autophagy associated cisplatin resistance by regulating the microRNA 30b/autophagy related gene 5 axis in gastric cancer
2	MiR-181a suppresses autophagy and sensitizes gastric cancer cells to cisplatin
3	Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells
4	"miR-216b enhances the efficacy of vemurafenib by targeting Beclin-1, UVRAG and ATG5 in melanoma"