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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATG12

Summary for ATG12

Gene information	Gene symbol	ATG12
	Ensembl ID	ENSG00000145782
	Entrez ID	9140
	Gene name	autophagy related 12
	Synonyms	APG12\|APG12L
	Gene type	protein_coding
	UniProtAcc	O94817

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Dataset with differentially expressed gene: ATG12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.292454	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.28501	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.277106	4.97e-27
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.628163	0.00e+00

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Expression of ATG12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATG12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ATG12	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating ATG12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATG12	hsa-miR-4684-3p	97.2056	NM_004707
ATG12	hsa-miR-30b-5p	97.0382	NM_004707
ATG12	hsa-miR-30a-5p	97.0382	NM_004707
ATG12	hsa-miR-30e-5p	97.0382	NM_004707
ATG12	hsa-miR-30d-5p	97.0382	NM_004707
ATG12	hsa-miR-30c-5p	97.0382	NM_004707
ATG12	hsa-miR-1305	95.4394	NM_004707
ATG12	hsa-miR-4474-5p	92.5433	NM_004707
ATG12	hsa-miR-3654	91.695	NM_004707
ATG12	hsa-miR-545-5p	90.8193	NM_004707
ATG12	hsa-miR-3163	90.3795	NM_001277783
ATG12	hsa-miR-4704-3p	88.6033	NM_004707
ATG12	hsa-miR-3169	87.7658	NM_004707
ATG12	hsa-miR-1258	87.2578	NM_004707
ATG12	hsa-miR-512-5p	86.7133	NM_004707
ATG12	hsa-miR-4740-5p	85.941	NM_001277783
ATG12	hsa-miR-198	85.7929	NM_004707
ATG12	hsa-miR-1827	84.3456	NM_004707
ATG12	hsa-miR-4712-3p	83.9481	NM_004707
ATG12	hsa-miR-1184	83.1241	NM_004707
ATG12	hsa-miR-570-3p	82.9844	NM_004707
ATG12	hsa-miR-642b-3p	82.3029	NM_001277783
ATG12	hsa-miR-642a-3p	82.3029	NM_001277783
ATG12	hsa-miR-23a-3p	81.9554	NM_004707
ATG12	hsa-miR-23b-3p	81.9554	NM_004707
ATG12	hsa-miR-23c	81.9554	NM_004707
ATG12	hsa-miR-1257	81.2558	NM_004707
ATG12	hsa-miR-325	80.9756	NM_004707
ATG12	hsa-miR-556-5p	80.7359	NM_004707

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Motifs and transcription factors (TFs) regulating ATG12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATG12	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ATG12	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
ATG12	transfac_pro__M06854	ZNF600 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."