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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: ATF6

Summary for ATF6

Gene informationGene symbol

ATF6

Ensembl ID

ENSG00000118217

Entrez ID

22926

Gene nameactivating transcription factor 6
SynonymsATF6A
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: ATF6

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-0.3486515.52e-21

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMalignant cells0.3390723.97e-26

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells0.2599050.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreMalignant cells0.3048240.00e+00

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Expression of ATF6 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ATF6

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATF6

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ATF6hsa-miR-548c-3p95.1746NM_007348
ATF6hsa-miR-6809-5p94.3337NM_007348
ATF6hsa-miR-31-5p93.523NM_007348
ATF6hsa-miR-212-5p92.2038NM_007348
ATF6hsa-miR-205292.1038NM_007348
ATF6hsa-miR-453091.7318NM_007348
ATF6hsa-miR-5197-5p89.3954NM_007348
ATF6hsa-miR-10526-3p88.8232NM_007348
ATF6hsa-miR-130388.4994NM_007348
ATF6hsa-miR-4753-3p86.2469NM_007348
ATF6hsa-miR-613484.0849NM_007348
ATF6hsa-miR-447083.7417NM_007348
ATF6hsa-miR-195-5p83.4695NM_007348
ATF6hsa-miR-16-5p83.4695NM_007348
ATF6hsa-miR-15b-5p83.4695NM_007348
ATF6hsa-miR-15a-5p83.4695NM_007348
ATF6hsa-miR-519382.7771NM_007348
ATF6hsa-miR-7106-5p82.6362NM_007348
ATF6hsa-miR-312382.6213NM_007348
ATF6hsa-miR-3682-5p82.1822NM_007348
ATF6hsa-miR-29b-1-5p82.0268NM_007348
ATF6hsa-miR-6730-5p81.991NM_007348
ATF6hsa-miR-424-5p81.9293NM_007348
ATF6hsa-miR-497-5p81.9293NM_007348
ATF6hsa-miR-6838-5p81.9293NM_007348
ATF6hsa-miR-3152-3p81.5645NM_007348
ATF6hsa-miR-548n81.118NM_007348
ATF6hsa-miR-548x-3p80.4921NM_007348
ATF6hsa-miR-548aj-3p80.4921NM_007348
ATF6hsa-miR-539-5p80.1874NM_007348
ATF6hsa-miR-5004-5p80.0592NM_007348
ATF6hsa-miR-4743-3p80.0392NM_007348
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Motifs and transcription factors (TFs) regulating ATF6

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ATF6transfac_pro__M01861ATF1 (directAnnotation).
ATF6taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2ELK1; GCM1 (directAnnotation).
ATF6transfac_public__M00039CREB1 (directAnnotation).
ATF6transfac_pro__M00691ATF1 (directAnnotation).
ATF6transfac_pro__M08803CREM (directAnnotation).
ATF6taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_reprZNF385D (directAnnotation).
ATF6transfac_pro__M05798ZNF517 (directAnnotation).
ATF6transfac_pro__M05538ZNF536 (inferredBy_Orthology).
ATF6taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAPETV4; GCM1 (directAnnotation).
ATF6transfac_pro__M04826EP300 (directAnnotation).
ATF6taipale_tf_pairs__ELF2_NATGCGGAAGTR_HTELF2 (directAnnotation).
ATF6metacluster_141.6MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ATF6jaspar__MA1708.1ETV7 (directAnnotation).
ATF6jaspar__MA0748.2YY2 (directAnnotation).
ATF6transfac_pro__M00492STAT1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."