Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE140440 | DU145 and PCÂ cell lines | Cell line | Prostate cancer | Prostate cancer | Chemotherapy | docetaxel | NA | Malignant cells | -2.06877 | 4.65e-03 |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | -0.486711 | 0.00e+00 |
GSE150930 | patients | Peripheral blood mononuclear cells | Chronic lymphocytic leukemia | Mucosa-assisted lymphoid tissue (MALT) lymphoma | Immunotherapy | rituximab + cyclophosphamide + fludarabine | NA | Malignant cells | -0.260048 | 2.83e-06 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Mono/Macro | 0.30375 | 5.17e-04 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Mono/Macro | -0.44527 | 2.11e-05 |
GSE189460 | patients | Bone marrow aspirate | Multiple myeloma | Multiple myeloma (MM) | Targeted therapy | bortezomib + melphalan + prednisolone | pre | Malignant cells | -0.272693 | 1.32e-06 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | pre | Malignant cells | 0.724129 | 0.00e+00 |
GSE139386 | H3122 cell line | Cell line | Lung cancer | EML4-ALK fusion-positive non-small cell lung cancer (NSCLC) | Targeted therapy | ceritinib | NA | Malignant cells | -0.319743 | 0.00e+00 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | -0.288795 | 7.04e-27 |
Gene symbol | motif | TF_highConf |
ATF5 | taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT | ELF2 (directAnnotation). |
ATF5 | metacluster_21.5 | HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology). |
ATF5 | tfdimers__MD00275 | POU2F1; TFAP2A (directAnnotation). |
ATF5 | metacluster_70.16 | POU5F1; POU5F1 (directAnnotation). |
ATF5 | tfdimers__MD00295 | EBF1; STAT6 (directAnnotation). |
ATF5 | metacluster_55.3 | E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology). |
ATF5 | transfac_pro__M00652 | NRF1 (directAnnotation). |
ATF5 | taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP | ATF4; TEF (directAnnotation). |
ATF5 | kznf__ZNF384_Schmitges2016_RCADE | ZNF384 (directAnnotation). |
ATF5 | tfdimers__MD00176 | E2F1; IRF3 (directAnnotation). |
ATF5 | metacluster_9.13 | LHX8 (directAnnotation). |
ATF5 | metacluster_2.7 | IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology). |
ATF5 | taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP | ATF4; CEBPD (directAnnotation). |
ATF5 | metacluster_167.5 | EHF; ELF5; NFATC3; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIC; SPIC; STAT5A (directAnnotation). ETS1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIC (inferredBy_Orthology). |
ATF5 | taipale_cyt_meth__HSF5_NRCGTTCTAGAAYGYN_eDBD_repr | HSF5 (directAnnotation). |
ATF5 | transfac_pro__M06468 | ZNF808 (directAnnotation). |
ATF5 | jaspar__MA1125.1 | ZNF384 (directAnnotation). |
ATF5 | jaspar__MA1939.1 | SREBF2 (directAnnotation). |
ATF5 | hdpi__TFAM | TFAM (directAnnotation). |
ATF5 | tfdimers__MD00550 | PITX3; TEAD1 (directAnnotation). |
ATF5 | taipale_tf_pairs__HOXB13_TBX21_ARGTGNNNNNNATAAA_CAP_repr | HOXB13; TBX21 (directAnnotation). |
ATF5 | tfdimers__MD00056 | EP300; ZEB1 (directAnnotation). |
ATF5 | tfdimers__MD00174 | PDX1; STAT6 (directAnnotation). |
ATF5 | metacluster_2.6 | IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology). |
ATF5 | taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1 | SPIB; TEAD4 (directAnnotation). |
ATF5 | transfac_pro__M06795 | ZNF780B (directAnnotation). |
ATF5 | transfac_pro__M05453 | ZBTB26 (directAnnotation). |
ATF5 | transfac_pro__M06712 | ZNF287 (directAnnotation). |
ATF5 | tfdimers__MD00446 | PDX1; TFAP2C (directAnnotation). |
ATF5 | transfac_pro__M06153 | ZNF83 (directAnnotation). |
ATF5 | tfdimers__MD00433 | NKX3-2; ZNF217 (directAnnotation). |
ATF5 | taipale_tf_pairs__TEAD4_SPDEF_RGWATSCGGATGNNNNTCCKNNN_CAP_repr | SPDEF; TEAD4 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |