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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ATF1

Summary for ATF1

Gene information	Gene symbol	ATF1
	Ensembl ID	ENSG00000123268
	Entrez ID	466
	Gene name	activating transcription factor 1
	Synonyms	TREB36
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ATF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.651696	2.78e-02
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.277847	1.39e-26
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.272218	1.85e-24

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Expression of ATF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATF1	hsa-miR-3163	99.5388	NM_005171
ATF1	hsa-miR-340-5p	99.2456	NM_005171
ATF1	hsa-miR-4775	99.148	NM_005171
ATF1	hsa-miR-5689	98.2965	NM_005171
ATF1	hsa-miR-8485	98.2369	NM_005171
ATF1	hsa-miR-548g-3p	98.0712	NM_005171
ATF1	hsa-miR-548c-3p	96.9564	NM_005171
ATF1	hsa-miR-548av-3p	96.6358	NM_005171
ATF1	hsa-miR-548j-3p	96.6221	NM_005171
ATF1	hsa-miR-548aj-3p	96.2079	NM_005171
ATF1	hsa-miR-548x-3p	96.2079	NM_005171
ATF1	hsa-miR-548ae-3p	95.9232	NM_005171
ATF1	hsa-miR-548aq-3p	95.9232	NM_005171
ATF1	hsa-miR-548am-3p	95.9232	NM_005171
ATF1	hsa-miR-548ah-3p	95.9232	NM_005171
ATF1	hsa-miR-616-5p	94.5543	NM_005171
ATF1	hsa-miR-371b-5p	94.5543	NM_005171
ATF1	hsa-miR-373-5p	94.5543	NM_005171
ATF1	hsa-miR-3613-3p	94.446	NM_005171
ATF1	hsa-miR-6759-3p	94.3162	NM_005171
ATF1	hsa-miR-190a-3p	92.857	NM_005171
ATF1	hsa-miR-9-5p	90.9827	NM_005171
ATF1	hsa-miR-217-5p	90.5907	NM_005171
ATF1	hsa-miR-6807-3p	90.5907	NM_005171
ATF1	hsa-miR-922	90.4147	NM_005171
ATF1	hsa-miR-500b-5p	90.3849	NM_005171
ATF1	hsa-miR-362-5p	90.3849	NM_005171
ATF1	hsa-miR-32-3p	90.248	NM_005171
ATF1	hsa-miR-487b-5p	90.2091	NM_005171
ATF1	hsa-miR-487a-5p	90.2091	NM_005171
ATF1	hsa-miR-4668-3p	89.2938	NM_005171
ATF1	hsa-miR-6817-5p	89.1283	NM_005171
ATF1	hsa-miR-4769-3p	89.1283	NM_005171
ATF1	hsa-miR-6773-3p	87.7835	NM_005171
ATF1	hsa-miR-5688	86.9786	NM_005171
ATF1	hsa-miR-5011-5p	86.974	NM_005171
ATF1	hsa-miR-6516-5p	86.4365	NM_005171
ATF1	hsa-miR-192-5p	85.7092	NM_005171
ATF1	hsa-miR-215-5p	85.7092	NM_005171
ATF1	hsa-miR-410-3p	85.3969	NM_005171
ATF1	hsa-miR-30a-5p	82.3722	NM_005171
ATF1	hsa-miR-30d-5p	82.3722	NM_005171
ATF1	hsa-miR-30c-5p	82.3722	NM_005171
ATF1	hsa-miR-30e-5p	82.3722	NM_005171
ATF1	hsa-miR-30b-5p	82.3722	NM_005171
ATF1	hsa-miR-1277-5p	82.3202	NM_005171
ATF1	hsa-miR-6505-5p	81.7935	NM_005171
ATF1	hsa-miR-495-3p	81.4526	NM_005171
ATF1	hsa-miR-323a-3p	81.0154	NM_005171
ATF1	hsa-miR-1290	80.9376	NM_005171

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Motifs and transcription factors (TFs) regulating ATF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATF1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ATF1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ATF1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ATF1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ATF1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ATF1	transfac_pro__M07387	ZBTB7A (directAnnotation).
ATF1	transfac_pro__M07436	WT1 (directAnnotation).
ATF1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ATF1	transfac_pro__M00716	ZBTB14 (directAnnotation).
ATF1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ATF1	hdpi__HIP2	UBE2K (directAnnotation).
ATF1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ATF1	transfac_pro__M04893	TAF1 (directAnnotation).
ATF1	transfac_pro__M03876	ZBTB33 (directAnnotation).
ATF1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ATF1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ATF1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ATF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATF1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ATF1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ATF1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ATF1	transfac_pro__M04950	EGR1 (directAnnotation).
ATF1	transfac_pro__M01182	HINFP (directAnnotation).
ATF1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ATF1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ATF1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
ATF1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ATF1	cisbp__M00968	MTF2 (directAnnotation).
ATF1	cisbp__M00341	PAX6 (directAnnotation).
ATF1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ATF1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ATF1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ATF1	transfac_pro__M01199	TRIM28 (directAnnotation).
ATF1	metacluster_151.2	ZNF23 (directAnnotation).
ATF1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ATF1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ATF1	metacluster_111.3	up	Malignant cells	GSE153697	NA
ATF1	jaspar__MA0604.1	up	Malignant cells	GSE153697	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."