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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ASXL1

Summary for ASXL1

Gene information	Gene symbol	ASXL1
	Ensembl ID	ENSG00000171456
	Entrez ID	171023
	Gene name	ASXL transcriptional regulator 1
	Synonyms	KIAA0978
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ASXL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.252856	1.47e-30
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.400939	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.253634	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.335806	2.92e-16
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.343704	0.00e+00

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Expression of ASXL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ASXL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ASXL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ASXL1	hsa-miR-5683	98.6931	NM_015338
ASXL1	hsa-miR-1185-2-3p	98.3593	NM_015338
ASXL1	hsa-let-7f-2-3p	98.3593	NM_015338
ASXL1	hsa-miR-1185-1-3p	98.3593	NM_015338
ASXL1	hsa-miR-8485	97.9776	NM_015338
ASXL1	hsa-miR-603	97.2517	NM_015338
ASXL1	hsa-miR-6747-3p	96.0648	NM_015338
ASXL1	hsa-miR-381-3p	94.3139	NM_015338
ASXL1	hsa-miR-300	94.3139	NM_015338
ASXL1	hsa-miR-539-3p	93.6218	NM_001164603
ASXL1	hsa-miR-485-3p	93.6218	NM_001164603
ASXL1	hsa-miR-298	92.7106	NM_015338
ASXL1	hsa-miR-3662	91.652	NM_015338
ASXL1	hsa-miR-1252-3p	91.2203	NM_015338
ASXL1	hsa-miR-4519	90.3082	NM_015338
ASXL1	hsa-miR-940	89.7578	NM_015338
ASXL1	hsa-miR-6893-5p	89.7578	NM_015338
ASXL1	hsa-miR-6808-5p	89.7578	NM_015338
ASXL1	hsa-miR-6499-3p	89.3228	NM_015338
ASXL1	hsa-miR-4778-5p	88.4618	NM_015338
ASXL1	hsa-miR-9-5p	87.6095	NM_015338
ASXL1	hsa-miR-1207-5p	87.4346	NM_015338
ASXL1	hsa-miR-668-3p	86.8787	NM_015338
ASXL1	hsa-miR-4524a-3p	86.3703	NM_015338
ASXL1	hsa-miR-760	85.9031	NM_015338
ASXL1	hsa-miR-3941	85.81	NM_015338
ASXL1	hsa-miR-4763-3p	83.8643	NM_015338
ASXL1	hsa-miR-3942-3p	83.8355	NM_015338
ASXL1	hsa-miR-362-3p	83.6479	NM_015338
ASXL1	hsa-miR-329-3p	83.6479	NM_015338
ASXL1	hsa-miR-217-5p	83.3032	NM_015338
ASXL1	hsa-miR-3177-5p	83.2683	NM_015338
ASXL1	hsa-miR-6083	83.1289	NM_015338
ASXL1	hsa-miR-138-1-3p	83.0089	NM_015338
ASXL1	hsa-miR-4456	81.6235	NM_015338
ASXL1	hsa-miR-7-5p	81.5937	NM_015338
ASXL1	hsa-miR-504-5p	80.2024	NM_015338
ASXL1	hsa-miR-4725-5p	80.2024	NM_015338
ASXL1	hsa-miR-4495	80.1566	NM_015338

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Motifs and transcription factors (TFs) regulating ASXL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ASXL1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ASXL1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
ASXL1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ASXL1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ASXL1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ASXL1	metacluster_3.14	WT1; WT1 (directAnnotation).
ASXL1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ASXL1	cisbp__M07938	E2F1 (directAnnotation).
ASXL1	transfac_pro__M04918	EGR1 (directAnnotation).
ASXL1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ASXL1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ASXL1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ASXL1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ASXL1	transfac_pro__M00430	E2F1 (directAnnotation).
ASXL1	transfac_pro__M04893	TAF1 (directAnnotation).
ASXL1	transfac_pro__M01199	TRIM28 (directAnnotation).
ASXL1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ASXL1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
ASXL1	hdpi__HIP2	UBE2K (directAnnotation).
ASXL1	metacluster_191.5	SPDEF (inferredBy_Orthology).
ASXL1	transfac_pro__M00938	E2F1 (directAnnotation).
ASXL1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ASXL1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ASXL1	hdpi__ELF2	ELF2 (directAnnotation).
ASXL1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ASXL1	cisbp__M00968	MTF2 (directAnnotation).
ASXL1	transfac_pro__M02898	SMAD3 (directAnnotation).
ASXL1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ASXL1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ASXL1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ASXL1	jaspar__MA1122.1	TFDP1 (directAnnotation).
ASXL1	transfac_pro__M07310	SP5 (directAnnotation).
ASXL1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ASXL1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ASXL1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ASXL1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ASXL1	cisbp__M00249	WT1 (directAnnotation).
ASXL1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
ASXL1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ASXL1	hdpi__TP73	TP73 (directAnnotation).
ASXL1	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
ASXL1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ASXL1	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
ASXL1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."