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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ASCL1

Summary for ASCL1

Gene information	Gene symbol	ASCL1
	Ensembl ID	ENSG00000139352
	Entrez ID	429
	Gene name	achaete-scute family bHLH transcription factor 1
	Synonyms	ASH1\|bHLHa46\|HASH1
	Gene type	protein_coding
	UniProtAcc	P50553

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Dataset with differentially expressed gene: ASCL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.276411	2.16e-37

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Expression of ASCL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ASCL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ASCL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ASCL1	hsa-miR-4778-3p	98.2485	NM_004316
ASCL1	hsa-miR-6873-3p	98.0373	NM_004316
ASCL1	hsa-miR-6833-3p	96.9782	NM_004316
ASCL1	hsa-miR-548an	96.7774	NM_004316
ASCL1	hsa-miR-4768-5p	96.0705	NM_004316
ASCL1	hsa-miR-497-3p	95.6754	NM_004316
ASCL1	hsa-miR-4789-5p	94.4717	NM_004316
ASCL1	hsa-miR-4659a-3p	94.4631	NM_004316
ASCL1	hsa-miR-4659b-3p	94.4631	NM_004316
ASCL1	hsa-let-7c-3p	94.0533	NM_004316
ASCL1	hsa-miR-2682-5p	93.973	NM_004316
ASCL1	hsa-miR-34b-5p	93.973	NM_004316
ASCL1	hsa-miR-449c-5p	93.973	NM_004316
ASCL1	hsa-miR-6079	93.786	NM_004316
ASCL1	hsa-miR-1179	92.1517	NM_004316
ASCL1	hsa-miR-4666a-5p	91.8555	NM_004316
ASCL1	hsa-miR-3714	91.4508	NM_004316
ASCL1	hsa-miR-374a-5p	91.2355	NM_004316
ASCL1	hsa-miR-504-3p	91.1432	NM_004316
ASCL1	hsa-miR-548l	90.3866	NM_004316
ASCL1	hsa-miR-6828-5p	90.0459	NM_004316
ASCL1	hsa-miR-655-3p	89.2034	NM_004316
ASCL1	hsa-miR-374c-5p	89.2034	NM_004316
ASCL1	hsa-miR-374b-5p	89.1835	NM_004316
ASCL1	hsa-miR-2054	86.8713	NM_004316
ASCL1	hsa-miR-651-3p	86.0162	NM_004316
ASCL1	hsa-miR-6516-5p	82.5268	NM_004316
ASCL1	hsa-miR-6823-5p	82.5099	NM_004316
ASCL1	hsa-miR-3605-3p	82.052	NM_004316
ASCL1	hsa-miR-548ap-3p	80.8316	NM_004316
ASCL1	hsa-miR-548aa	80.8316	NM_004316
ASCL1	hsa-miR-548t-3p	80.8316	NM_004316
ASCL1	hsa-miR-4520-3p	80.3415	NM_004316

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Motifs and transcription factors (TFs) regulating ASCL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ASCL1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ASCL1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
ASCL1	metacluster_3.14	WT1; WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."