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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ASCC1

Summary for ASCC1

Gene information	Gene symbol	ASCC1
	Ensembl ID	ENSG00000138303
	Entrez ID	51008
	Gene name	activating signal cointegrator 1 complex subunit 1
	Synonyms	ASC1p50\|CGI-18\|Em:AC022392.3\|p50
	Gene type	protein_coding
	UniProtAcc	Q8N9N2

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Dataset with differentially expressed gene: ASCC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.377065	2.61e-31

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Expression of ASCC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ASCC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ASCC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ASCC1	hsa-miR-4516	94.9151	NM_001198799
ASCC1	hsa-miR-4436b-5p	94.0439	NM_001198798
ASCC1	hsa-miR-186-5p	93.558	NM_001198798
ASCC1	hsa-miR-6761-5p	91.1088	NM_001198799
ASCC1	hsa-miR-5004-5p	91.1037	NM_001198798
ASCC1	hsa-miR-4434	89.5839	NM_001198799
ASCC1	hsa-miR-5703	89.5839	NM_001198799
ASCC1	hsa-miR-6866-5p	89.2409	NM_001198798
ASCC1	hsa-miR-1304-3p	87.4424	NM_001198798
ASCC1	hsa-miR-4483	86.6575	NM_001198798
ASCC1	hsa-miR-4307	85.6692	NM_001198798
ASCC1	hsa-miR-4452	84.8616	NM_001198799
ASCC1	hsa-miR-6827-5p	84.0523	NM_001198799
ASCC1	hsa-miR-4768-3p	83.9246	NM_001198799
ASCC1	hsa-miR-4251	83.4084	NM_001198799
ASCC1	hsa-miR-31-5p	83.3286	NM_001198798
ASCC1	hsa-miR-452-5p	83.0332	NM_001198798
ASCC1	hsa-miR-892c-3p	83.0332	NM_001198798
ASCC1	hsa-miR-4676-3p	83.0332	NM_001198798
ASCC1	hsa-miR-496	82.1747	NM_001198798
ASCC1	hsa-miR-3065-3p	82.0997	NM_001198799
ASCC1	hsa-miR-1293	82.0527	NM_001198798

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Motifs and transcription factors (TFs) regulating ASCC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ASCC1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."