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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ASB8

Summary for ASB8

Gene information	Gene symbol	ASB8
	Ensembl ID	ENSG00000177981
	Entrez ID	140461
	Gene name	ankyrin repeat and SOCS box containing 8
	Synonyms	FLJ21255\|MGC5540
	Gene type	protein_coding
	UniProtAcc	Q9H765

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Dataset with differentially expressed gene: ASB8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.281101	3.03e-42
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.29757	0.00e+00

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Expression of ASB8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ASB8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ASB8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ASB8	hsa-miR-4685-5p	97.267	NM_001319300
ASB8	hsa-miR-6837-5p	97.267	NM_001319300
ASB8	hsa-miR-3664-3p	96.2584	NM_001319296
ASB8	hsa-miR-3922-3p	95.6345	NM_001319300
ASB8	hsa-miR-3176	95.5896	NM_001319300
ASB8	hsa-miR-6826-5p	92.5552	NM_001319301
ASB8	hsa-miR-95-5p	90.4932	NM_001319296
ASB8	hsa-miR-497-3p	89.6837	NM_001319296
ASB8	hsa-miR-1288-5p	87.1287	NM_001319296
ASB8	hsa-miR-3130-3p	87.0325	NM_001319296
ASB8	hsa-miR-6882-5p	86.6681	NM_001319296
ASB8	hsa-miR-12132	86.3073	NM_001319296
ASB8	hsa-miR-32-3p	86.1109	NM_001319296
ASB8	hsa-miR-335-3p	86.0089	NM_001319301
ASB8	hsa-miR-607	85.4081	NM_001319296
ASB8	hsa-miR-4652-3p	85.1481	NM_001319296
ASB8	hsa-miR-26a-2-3p	84.8222	NM_001319300
ASB8	hsa-miR-26a-1-3p	84.8222	NM_001319300
ASB8	hsa-miR-4735-5p	84.8054	NM_001319296
ASB8	hsa-miR-4743-3p	84.5094	NM_001319296
ASB8	hsa-miR-12136	84.04	NM_001319296
ASB8	hsa-miR-551b-5p	83.8268	NM_001319296
ASB8	hsa-miR-12130	82.2924	NM_001319296
ASB8	hsa-miR-4677-5p	81.9268	NM_001319301
ASB8	hsa-miR-767-5p	81.8593	NM_001319301
ASB8	hsa-miR-3940-5p	81.4303	NM_001319296
ASB8	hsa-miR-4507	81.4303	NM_001319296
ASB8	hsa-miR-3169	80.9393	NM_001319296
ASB8	hsa-miR-4766-5p	80.1469	NM_001319296

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Motifs and transcription factors (TFs) regulating ASB8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ASB8	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ASB8	cisbp__M00788	ZFY (inferredBy_Orthology).
ASB8	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ASB8	transfac_pro__M01199	TRIM28 (directAnnotation).
ASB8	hdpi__HIP2	UBE2K (directAnnotation).
ASB8	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ASB8	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ASB8	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ASB8	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
ASB8	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ASB8	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ASB8	hdpi__RARA	RARA (directAnnotation).
ASB8	hdpi__ELF2	ELF2 (directAnnotation).
ASB8	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
ASB8	jaspar__MA1583.1	ZFP57 (directAnnotation).
ASB8	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ASB8	cisbp__M01863	ZNF711 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."