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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ASAP2

Summary for ASAP2

Gene information	Gene symbol	ASAP2
	Ensembl ID	ENSG00000151693
	Entrez ID	8853
	Gene name	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
	Synonyms	CENTB3\|DDEF2\|KIAA0400\|PAP\|SHAG1
	Gene type	protein_coding
	UniProtAcc	O43150

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Dataset with differentially expressed gene: ASAP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.61804	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.324493	3.22e-16

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Expression of ASAP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ASAP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ASAP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ASAP2	hsa-miR-7154-5p	99.6903	NM_001135191
ASAP2	hsa-miR-3121-3p	96.6571	NM_001135191
ASAP2	hsa-miR-29b-3p	95.1547	NM_001135191
ASAP2	hsa-miR-29a-3p	95.1547	NM_001135191
ASAP2	hsa-miR-29c-3p	95.1547	NM_001135191
ASAP2	hsa-miR-5682	94.8807	NM_001135191
ASAP2	hsa-miR-199a-3p	94.8706	NM_001135191
ASAP2	hsa-miR-3129-5p	94.8706	NM_001135191
ASAP2	hsa-miR-199b-3p	94.8706	NM_001135191
ASAP2	hsa-miR-10523-5p	94.4373	NM_001135191
ASAP2	hsa-miR-5003-5p	94.066	NM_001135191
ASAP2	hsa-miR-384	93.5216	NM_001135191
ASAP2	hsa-miR-487a-3p	93.4052	NM_001135191
ASAP2	hsa-miR-154-3p	93.4052	NM_001135191
ASAP2	hsa-miR-548n	92.9032	NM_001135191
ASAP2	hsa-miR-155-5p	92.8046	NM_001135191
ASAP2	hsa-miR-497-3p	92.5772	NM_001135191
ASAP2	hsa-miR-5195-3p	92.059	NM_001135191
ASAP2	hsa-miR-145-5p	92.059	NM_001135191
ASAP2	hsa-miR-548x-3p	91.4423	NM_001135191
ASAP2	hsa-miR-548aj-3p	91.4423	NM_001135191
ASAP2	hsa-miR-3924	91.1621	NM_001135191
ASAP2	hsa-miR-1263	91.1429	NM_001135191
ASAP2	hsa-miR-1206	89.9319	NM_001135191
ASAP2	hsa-miR-3128	89.736	NM_001135191
ASAP2	hsa-miR-1468-3p	89.7273	NM_001135191
ASAP2	hsa-miR-433-3p	89.5786	NM_001135191
ASAP2	hsa-miR-5571-3p	89.4357	NM_001135191
ASAP2	hsa-miR-548ae-3p	89.3406	NM_001135191
ASAP2	hsa-miR-548j-3p	89.3406	NM_001135191
ASAP2	hsa-miR-548ah-3p	89.3406	NM_001135191
ASAP2	hsa-miR-548am-3p	89.3406	NM_001135191
ASAP2	hsa-miR-548aq-3p	89.3406	NM_001135191
ASAP2	hsa-miR-1185-1-3p	89.2555	NM_001135191
ASAP2	hsa-let-7f-2-3p	89.2555	NM_001135191
ASAP2	hsa-miR-1185-2-3p	89.2555	NM_001135191
ASAP2	hsa-miR-8080	89.078	NM_001135191
ASAP2	hsa-miR-3163	88.6833	NM_001135191
ASAP2	hsa-miR-3685	88.5204	NM_001135191
ASAP2	hsa-miR-19a-3p	88.0744	NM_001135191
ASAP2	hsa-miR-19b-3p	88.0744	NM_001135191
ASAP2	hsa-miR-4534	87.8893	NM_001135191
ASAP2	hsa-miR-190a-5p	87.7655	NM_001135191
ASAP2	hsa-miR-190b-5p	87.7655	NM_001135191
ASAP2	hsa-miR-876-5p	87.5755	NM_001135191
ASAP2	hsa-miR-552-5p	87.4865	NM_001135191
ASAP2	hsa-miR-520f-3p	87.3084	NM_001135191
ASAP2	hsa-miR-3140-3p	87.253	NM_001135191
ASAP2	hsa-miR-3167	87.1767	NM_001135191
ASAP2	hsa-miR-340-5p	86.5203	NM_001135191

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Motifs and transcription factors (TFs) regulating ASAP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ASAP2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ASAP2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ASAP2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ASAP2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
ASAP2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ASAP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ASAP2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ASAP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ASAP2	transfac_pro__M00652	NRF1 (directAnnotation).
ASAP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ASAP2	transfac_pro__M04866	HDAC2 (directAnnotation).
ASAP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
ASAP2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ASAP2	jaspar__MA0079.5	SP1 (directAnnotation).
ASAP2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
ASAP2	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
ASAP2	transfac_pro__M01253	CNOT3 (directAnnotation).
ASAP2	transfac_pro__M04817	ZBTB33 (directAnnotation).
ASAP2	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."