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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ASAH1

Summary for ASAH1

Gene information	Gene symbol	ASAH1
	Ensembl ID	ENSG00000104763
	Entrez ID	427
	Gene name	N-acylsphingosine amidohydrolase 1
	Synonyms	AC\|ACDase\|ASAH\|FLJ21558\|PHP32
	Gene type	protein_coding
	UniProtAcc	Q13510

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Dataset with differentially expressed gene: ASAH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Progenitors	0.484184	5.26e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.309066	2.39e-08
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.313898	6.65e-13
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.270232	1.40e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.376677	1.59e-07
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.607944	3.28e-13
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.395725	1.04e-12
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.283853	2.06e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.354473	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.54168	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.722068	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.41652	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.326666	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.6443	0.00e+00

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Expression of ASAH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ASAH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ASAH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ASAH1	hsa-let-7f-2-3p	95.4099	NM_001127505
ASAH1	hsa-miR-1185-2-3p	94.5065	NM_001127505
ASAH1	hsa-miR-1185-1-3p	94.5065	NM_001127505
ASAH1	hsa-miR-6794-5p	91.3091	NM_001127505
ASAH1	hsa-miR-4716-3p	91.3091	NM_001127505
ASAH1	hsa-miR-4762-3p	90.6321	NM_001127505
ASAH1	hsa-miR-380-3p	90.6046	NM_001127505
ASAH1	hsa-miR-625-5p	89.8019	NM_001127505
ASAH1	hsa-miR-3686	89.1664	NM_001127505
ASAH1	hsa-miR-5003-3p	89.156	NM_001127505
ASAH1	hsa-miR-9985	89.0808	NM_001127505
ASAH1	hsa-miR-27a-3p	89.0808	NM_001127505
ASAH1	hsa-miR-27b-3p	89.0808	NM_001127505
ASAH1	hsa-miR-4699-3p	88.5811	NM_001127505
ASAH1	hsa-miR-4803	88.2949	NM_001127505
ASAH1	hsa-miR-3120-3p	88.0172	NM_001127505
ASAH1	hsa-let-7b-3p	85.6075	NM_001127505
ASAH1	hsa-let-7a-3p	85.6075	NM_001127505
ASAH1	hsa-miR-98-3p	85.6075	NM_001127505
ASAH1	hsa-let-7f-1-3p	85.6075	NM_001127505
ASAH1	hsa-miR-4278	85.4343	NM_001127505
ASAH1	hsa-miR-6831-5p	83.6126	NM_001127505
ASAH1	hsa-miR-3927-3p	82.1325	NM_001127505
ASAH1	hsa-miR-4789-5p	81.8184	NM_001127505

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Motifs and transcription factors (TFs) regulating ASAH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ASAH1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
ASAH1	transfac_pro__M01861	ATF1 (directAnnotation).
ASAH1	metacluster_52.11	ZNF184 (directAnnotation).
ASAH1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
ASAH1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
ASAH1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
ASAH1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ASAH1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
ASAH1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ASAH1	jaspar__MA0748.2	YY2 (directAnnotation).
ASAH1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ASAH1	hdpi__FLI1	FLI1 (directAnnotation).
ASAH1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ASAH1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
ASAH1	swissregulon__hs__CEBPB	CEBPB (directAnnotation).
ASAH1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
ASAH1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ASAH1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ASAH1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ASAH1	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
ASAH1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
ASAH1	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
ASAH1	taipale__NR4A2_full_AGGTCANNNNNTGACCT_repr	NR4A2 (directAnnotation).
ASAH1	transfac_pro__M06404	ZNF497 (directAnnotation).
ASAH1	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
ASAH1	transfac_pro__M04855	IRF4 (directAnnotation).
ASAH1	metacluster_13.1	ZNF7 (directAnnotation).
ASAH1	transfac_pro__M04870	HDAC2 (directAnnotation).
ASAH1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ASAH1	hocomoco__HSF1_HUMAN.H11MO.1.A	HSF1 (directAnnotation).
ASAH1	transfac_pro__M04706	RELA (directAnnotation).
ASAH1	metacluster_21.4	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
ASAH1	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
ASAH1	hocomoco__HSF1_MOUSE.H11MO.1.A	HSF1 (inferredBy_Orthology).
ASAH1	hdpi__NFATC3	NFATC3 (directAnnotation).
ASAH1	cisbp__M02748	NFATC1 (directAnnotation).
ASAH1	transfac_pro__M07981	ATF3 (inferredBy_Orthology).
ASAH1	c2h2_zfs__M0385	MTF1 (inferredBy_Orthology).
ASAH1	transfac_pro__M05985	ZNF394 (inferredBy_Orthology).
ASAH1	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
ASAH1	transfac_pro__M06807	SALL2 (inferredBy_Orthology).
ASAH1	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
ASAH1	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
ASAH1	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
ASAH1	metacluster_56.3	HSF2 (directAnnotation).
ASAH1	metacluster_56.5	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
ASAH1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRWMAACAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
ASAH1	transfac_pro__M07384	HIF1A (directAnnotation).
ASAH1	transfac_pro__M06432	ZNF571 (directAnnotation).
ASAH1	transfac_pro__M06595	ZNF799 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."