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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARMCX3

Summary for ARMCX3

Gene information	Gene symbol	ARMCX3
	Ensembl ID	ENSG00000102401
	Entrez ID	51566
	Gene name	armadillo repeat containing X-linked 3
	Synonyms	ALEX3\|GASP6
	Gene type	protein_coding
	UniProtAcc	Q9UH62

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Dataset with differentially expressed gene: ARMCX3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.279609	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.268199	1.49e-04
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.499584	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.498067	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.287917	3.50e-05
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.335405	5.35e-05

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Expression of ARMCX3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARMCX3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARMCX3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARMCX3	hsa-miR-3682-3p	97.9998	NM_016607
ARMCX3	hsa-miR-6875-3p	95.0932	NM_016607
ARMCX3	hsa-miR-664a-3p	94.4093	NM_016607
ARMCX3	hsa-miR-4659a-3p	93.2657	NM_016607
ARMCX3	hsa-miR-4659b-3p	93.2657	NM_016607
ARMCX3	hsa-miR-660-5p	90.832	NM_016607
ARMCX3	hsa-miR-4307	90.6955	NM_016607
ARMCX3	hsa-miR-4474-5p	89.4785	NM_016607
ARMCX3	hsa-miR-6773-3p	89.1854	NM_016607
ARMCX3	hsa-miR-12136	89.012	NM_016607
ARMCX3	hsa-miR-6760-3p	88.8701	NM_016607
ARMCX3	hsa-miR-6754-3p	88.4438	NM_016607
ARMCX3	hsa-miR-338-3p	88.2885	NM_016607
ARMCX3	hsa-miR-6880-5p	87.9528	NM_016607
ARMCX3	hsa-miR-6074	87.816	NM_016607
ARMCX3	hsa-miR-885-3p	87.6543	NM_016607
ARMCX3	hsa-miR-628-3p	86.003	NM_016607
ARMCX3	hsa-miR-589-3p	85.8214	NM_016607
ARMCX3	hsa-miR-7157-5p	85.6329	NM_016607
ARMCX3	hsa-miR-8073	85.5233	NM_016607
ARMCX3	hsa-miR-221-5p	85.5233	NM_016607
ARMCX3	hsa-miR-298	85.3146	NM_016607
ARMCX3	hsa-miR-4310	85.0504	NM_016607
ARMCX3	hsa-miR-371b-5p	83.096	NM_016607
ARMCX3	hsa-miR-373-5p	83.096	NM_016607
ARMCX3	hsa-miR-616-5p	83.096	NM_016607
ARMCX3	hsa-miR-412-3p	82.7323	NM_016607
ARMCX3	hsa-miR-3117-5p	81.771	NM_016607
ARMCX3	hsa-miR-3617-3p	81.4346	NM_016607
ARMCX3	hsa-miR-12123	81.1351	NM_016607
ARMCX3	hsa-miR-548y	80.4691	NM_016607
ARMCX3	hsa-miR-548h-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548b-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548au-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548w	80.4691	NM_016607
ARMCX3	hsa-miR-548ar-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548bb-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548c-5p	80.4691	NM_016607
ARMCX3	hsa-miR-559	80.4691	NM_016607
ARMCX3	hsa-miR-548ap-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548ak	80.4691	NM_016607
ARMCX3	hsa-miR-548ab	80.4691	NM_016607
ARMCX3	hsa-miR-548ad-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548i	80.4691	NM_016607
ARMCX3	hsa-miR-548j-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548as-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548ay-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548a-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548am-5p	80.4691	NM_016607
ARMCX3	hsa-miR-548aq-5p	80.4691	NM_016607

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Motifs and transcription factors (TFs) regulating ARMCX3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARMCX3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ARMCX3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARMCX3	transfac_pro__M07397	ZNF148 (directAnnotation).
ARMCX3	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ARMCX3	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ARMCX3	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ARMCX3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ARMCX3	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ARMCX3	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ARMCX3	transfac_pro__M01175	ZBTB7B (directAnnotation).
ARMCX3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARMCX3	tfdimers__MD00151	CHURC1 (directAnnotation).
ARMCX3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ARMCX3	transfac_pro__M01303	SP1 (directAnnotation).
ARMCX3	transfac_pro__M01714	KLF15 (directAnnotation).
ARMCX3	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ARMCX3	metacluster_3.14	WT1; WT1 (directAnnotation).
ARMCX3	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ARMCX3	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ARMCX3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ARMCX3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ARMCX3	transfac_pro__M07436	WT1 (directAnnotation).
ARMCX3	transfac_pro__M02281	SP1 (directAnnotation).
ARMCX3	transfac_public__M00491	PATZ1 (directAnnotation).
ARMCX3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ARMCX3	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ARMCX3	transfac_pro__M01861	ATF1 (directAnnotation).
ARMCX3	transfac_pro__M04826	EP300 (directAnnotation).
ARMCX3	metacluster_81.7	CREB1 (directAnnotation).
ARMCX3	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
ARMCX3	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
ARMCX3	transfac_pro__M06063	ZNF99 (directAnnotation).
ARMCX3	cisbp__M01725	SREBF2 (inferredBy_Orthology).
ARMCX3	metacluster_57.2	BACH1; MITF; MITF; TFE3; TFE3; TFE3; TFEB; USF2 (directAnnotation). MITF; TFE3; USF1; USF2 (inferredBy_Orthology).
ARMCX3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ARMCX3	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ARMCX3	transfac_pro__M07329	SP7 (directAnnotation).
ARMCX3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ARMCX3	transfac_pro__M01837	KLF11 (directAnnotation).
ARMCX3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ARMCX3	swissregulon__hs__KLF6	KLF6 (directAnnotation).
ARMCX3	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."