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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARL8B

Summary for ARL8B

Gene information	Gene symbol	ARL8B
	Ensembl ID	ENSG00000134108
	Entrez ID	55207
	Gene name	ADP ribosylation factor like GTPase 8B
	Synonyms	ARL10C\|FLJ10702\|Gie1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ARL8B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.265341	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.319525	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.371496	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.255037	4.18e-36

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Expression of ARL8B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARL8B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARL8B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARL8B	hsa-miR-4717-3p	99.0599	NM_018184
ARL8B	hsa-miR-5589-3p	98.2415	NM_018184
ARL8B	hsa-miR-4714-5p	97.0439	NM_018184
ARL8B	hsa-miR-23a-3p	96.4025	NM_018184
ARL8B	hsa-miR-23c	96.4025	NM_018184
ARL8B	hsa-miR-23b-3p	96.4025	NM_018184
ARL8B	hsa-miR-320d	95.2362	NM_018184
ARL8B	hsa-miR-4429	95.2362	NM_018184
ARL8B	hsa-miR-320b	95.2362	NM_018184
ARL8B	hsa-miR-320a-3p	95.2362	NM_018184
ARL8B	hsa-miR-320c	95.2362	NM_018184
ARL8B	hsa-miR-4426	94.7813	NM_018184
ARL8B	hsa-miR-148a-3p	94.4899	NM_018184
ARL8B	hsa-miR-152-3p	94.4899	NM_018184
ARL8B	hsa-miR-148b-3p	94.4899	NM_018184
ARL8B	hsa-miR-4999-5p	94.1255	NM_018184
ARL8B	hsa-miR-4662b	94.0225	NM_018184
ARL8B	hsa-miR-4647	94.0225	NM_018184
ARL8B	hsa-miR-6834-3p	92.9058	NM_018184
ARL8B	hsa-miR-6749-3p	92.8709	NM_018184
ARL8B	hsa-miR-4796-5p	92.6225	NM_018184
ARL8B	hsa-miR-5197-3p	92.3336	NM_018184
ARL8B	hsa-miR-539-5p	92.139	NM_018184
ARL8B	hsa-miR-4299	92.0695	NM_018184
ARL8B	hsa-miR-4733-5p	91.7451	NM_018184
ARL8B	hsa-miR-5009-3p	91.5564	NM_018184
ARL8B	hsa-miR-377-3p	91.3474	NM_018184
ARL8B	hsa-miR-4799-5p	91.284	NM_018184
ARL8B	hsa-miR-2467-3p	91.0178	NM_018184
ARL8B	hsa-miR-146a-3p	90.9964	NM_018184
ARL8B	hsa-miR-7856-5p	90.8389	NM_018184
ARL8B	hsa-miR-548ar-3p	90.5959	NM_018184
ARL8B	hsa-miR-7-5p	90.5806	NM_018184
ARL8B	hsa-miR-664a-3p	90.5708	NM_018184
ARL8B	hsa-miR-548f-3p	90.3115	NM_018184
ARL8B	hsa-miR-548az-3p	90.3115	NM_018184
ARL8B	hsa-miR-548a-3p	90.3115	NM_018184
ARL8B	hsa-miR-548e-3p	90.3115	NM_018184
ARL8B	hsa-miR-548bc	90.3115	NM_018184
ARL8B	hsa-miR-4699-3p	90.2531	NM_018184
ARL8B	hsa-miR-545-5p	89.5055	NM_018184
ARL8B	hsa-miR-4423-3p	89.0639	NM_018184
ARL8B	hsa-miR-6867-5p	88.8299	NM_018184
ARL8B	hsa-miR-12136	88.8189	NM_018184
ARL8B	hsa-miR-5582-5p	88.803	NM_018184
ARL8B	hsa-miR-4291	88.7984	NM_018184
ARL8B	hsa-miR-3977	88.7203	NM_018184
ARL8B	hsa-miR-7155-5p	88.5868	NM_018184
ARL8B	hsa-miR-6847-5p	88.2231	NM_018184
ARL8B	hsa-miR-6844	88.1855	NM_018184

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Motifs and transcription factors (TFs) regulating ARL8B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARL8B	metacluster_7.13	ZFX (directAnnotation).
ARL8B	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ARL8B	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
ARL8B	metacluster_151.2	ZNF23 (directAnnotation).
ARL8B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARL8B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARL8B	transfac_pro__M06071	ZNF814 (directAnnotation).
ARL8B	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
ARL8B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ARL8B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARL8B	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ARL8B	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ARL8B	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ARL8B	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ARL8B	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ARL8B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ARL8B	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ARL8B	transfac_pro__M04866	HDAC2 (directAnnotation).
ARL8B	jaspar__MA1122.1	TFDP1 (directAnnotation).
ARL8B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ARL8B	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ARL8B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ARL8B	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ARL8B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARL8B	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ARL8B	jaspar__MA1721.1	ZNF93 (directAnnotation).
ARL8B	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ARL8B	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ARL8B	transfac_pro__M01199	TRIM28 (directAnnotation).
ARL8B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARL8B	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ARL8B	transfac_pro__M01253	CNOT3 (directAnnotation).
ARL8B	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ARL8B	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ARL8B	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ARL8B	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ARL8B	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ARL8B	cisbp__M00968	MTF2 (directAnnotation).
ARL8B	jaspar__MA0748.2	YY2 (directAnnotation).
ARL8B	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ARL8B	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ARL8B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARL8B	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ARL8B	transfac_pro__M00938	E2F1 (directAnnotation).
ARL8B	transfac_pro__M04893	TAF1 (directAnnotation).
ARL8B	transfac_pro__M04817	ZBTB33 (directAnnotation).
ARL8B	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ARL8B	metacluster_175.1	ZNF283 (directAnnotation).
ARL8B	cisbp__M00788	ZFY (inferredBy_Orthology).
ARL8B	tfdimers__MD00364	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."