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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARL6IP1

Summary for ARL6IP1

Gene information	Gene symbol	ARL6IP1
	Ensembl ID	ENSG00000170540
	Entrez ID	23204
	Gene name	ADP ribosylation factor like GTPase 6 interacting protein 1
	Synonyms	AIP1\|ARL6IP\|ARMER\|KIAA0069\|SPG61
	Gene type	protein_coding
	UniProtAcc	Q15041

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Dataset with differentially expressed gene: ARL6IP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.364709	1.12e-23
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.417813	7.20e-21
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.574793	2.81e-11
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.389392	1.80e-07
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.907666	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.287441	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.426943	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.318615	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.450803	1.70e-09
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.1194	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.730402	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.482979	0.00e+00

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Expression of ARL6IP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARL6IP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARL6IP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARL6IP1	hsa-miR-1244	95.7378	NM_001313858
ARL6IP1	hsa-miR-6843-3p	95.2234	NM_001313858
ARL6IP1	hsa-miR-6848-3p	95.2234	NM_001313858
ARL6IP1	hsa-miR-148b-3p	94.9425	NM_001313858
ARL6IP1	hsa-miR-152-3p	94.9425	NM_001313858
ARL6IP1	hsa-miR-148a-3p	94.9425	NM_001313858
ARL6IP1	hsa-miR-548o-3p	94.7725	NM_001313858
ARL6IP1	hsa-miR-1323	94.6856	NM_001313858
ARL6IP1	hsa-miR-616-5p	94.5682	NM_015161
ARL6IP1	hsa-miR-373-5p	94.5682	NM_015161
ARL6IP1	hsa-miR-371b-5p	94.5682	NM_015161
ARL6IP1	hsa-miR-548av-3p	93.0915	NM_015161
ARL6IP1	hsa-miR-936	93.0199	NM_015161
ARL6IP1	hsa-miR-548ar-3p	91.5316	NM_015161
ARL6IP1	hsa-miR-548f-3p	90.7727	NM_015161
ARL6IP1	hsa-miR-548a-3p	90.7727	NM_015161
ARL6IP1	hsa-miR-548e-3p	90.7727	NM_015161
ARL6IP1	hsa-miR-548bc	90.7727	NM_015161
ARL6IP1	hsa-miR-548az-3p	90.7727	NM_015161
ARL6IP1	hsa-miR-454-3p	89.353	NM_001313858
ARL6IP1	hsa-miR-548f-5p	89.2805	NM_015161
ARL6IP1	hsa-miR-3663-5p	88.0575	NM_015161
ARL6IP1	hsa-miR-4699-3p	87.9571	NM_001313858
ARL6IP1	hsa-miR-1324	87.9202	NM_015161
ARL6IP1	hsa-miR-548aj-5p	87.585	NM_015161
ARL6IP1	hsa-miR-548g-5p	87.585	NM_015161
ARL6IP1	hsa-miR-548x-5p	87.585	NM_015161
ARL6IP1	hsa-miR-4713-5p	87.4621	NM_015161
ARL6IP1	hsa-miR-6515-3p	86.229	NM_015161
ARL6IP1	hsa-miR-3666	85.5252	NM_001313858
ARL6IP1	hsa-miR-130b-3p	85.5252	NM_001313858
ARL6IP1	hsa-miR-130a-3p	85.5252	NM_001313858
ARL6IP1	hsa-miR-301a-3p	85.5252	NM_001313858
ARL6IP1	hsa-miR-301b-3p	85.5252	NM_001313858
ARL6IP1	hsa-miR-4295	85.5252	NM_001313858
ARL6IP1	hsa-miR-555	85.2813	NM_015161
ARL6IP1	hsa-miR-488-5p	84.1122	NM_015161
ARL6IP1	hsa-miR-5692a	83.1325	NM_001313858
ARL6IP1	hsa-miR-3120-3p	82.9127	NM_001313858
ARL6IP1	hsa-miR-222-5p	81.9739	NM_015161
ARL6IP1	hsa-miR-548e-5p	80.8415	NM_015161
ARL6IP1	hsa-miR-6792-5p	80.7331	NM_015161
ARL6IP1	hsa-miR-3059-3p	80.35	NM_015161
ARL6IP1	hsa-miR-197-3p	80.222	NM_015161

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Motifs and transcription factors (TFs) regulating ARL6IP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARL6IP1	metacluster_7.13	ZFX (directAnnotation).
ARL6IP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARL6IP1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ARL6IP1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ARL6IP1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ARL6IP1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ARL6IP1	metacluster_141.4	GLIS2 (directAnnotation).
ARL6IP1	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
ARL6IP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ARL6IP1	metacluster_172.6	CHD2; E2F1 (directAnnotation).
ARL6IP1	hdpi__TIMELESS	TIMELESS (directAnnotation).
ARL6IP1	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
ARL6IP1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
ARL6IP1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ARL6IP1	jaspar__MA0502.2	NFYB (directAnnotation).
ARL6IP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARL6IP1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ARL6IP1	hdpi__TP73	TP73 (directAnnotation).
ARL6IP1	metacluster_182.10	ZFX (directAnnotation).
ARL6IP1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ARL6IP1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ARL6IP1	cisbp__M00788	ZFY (inferredBy_Orthology).
ARL6IP1	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
ARL6IP1	metacluster_22.25	NFE2L2 (directAnnotation).
ARL6IP1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
ARL6IP1	metacluster_22.17	NFE2 (directAnnotation).
ARL6IP1	tfdimers__MD00516	SOX10 (directAnnotation).
ARL6IP1	metacluster_22.39	NFE2L2 (directAnnotation).
ARL6IP1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ARL6IP1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ARL6IP1	transfac_pro__M04748	GABPA (directAnnotation).
ARL6IP1	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
ARL6IP1	transfac_pro__M05697	ZNF235 (directAnnotation).
ARL6IP1	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
ARL6IP1	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
ARL6IP1	jaspar__MA1125.1	ZNF384 (directAnnotation).
ARL6IP1	metacluster_22.29	NFE2 (directAnnotation).
ARL6IP1	transfac_pro__M04887	TCF12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."