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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ARL5B

Summary for ARL5B

Gene information	Gene symbol	ARL5B
	Ensembl ID	ENSG00000165997
	Entrez ID	221079
	Gene name	ADP ribosylation factor like GTPase 5B
	Synonyms	ARL8
	Gene type	protein_coding
	UniProtAcc	Q96KC2

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Dataset with differentially expressed gene: ARL5B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.287364	4.13e-09
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	-0.425668	1.64e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.355516	5.46e-21
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.346937	4.46e-05
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.263289	2.70e-10

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Expression of ARL5B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARL5B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARL5B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARL5B	hsa-miR-607	96.6998	NM_178815
ARL5B	hsa-miR-1277-5p	96.6282	NM_178815
ARL5B	hsa-miR-4282	95.5121	NM_178815
ARL5B	hsa-miR-12122	95.137	NM_178815
ARL5B	hsa-miR-512-3p	94.3469	NM_178815
ARL5B	hsa-miR-145-3p	93.842	NM_178815
ARL5B	hsa-miR-3121-3p	93.4226	NM_178815
ARL5B	hsa-miR-12136	92.7188	NM_178815
ARL5B	hsa-miR-1297	92.0416	NM_178815
ARL5B	hsa-miR-4775	92.0103	NM_178815
ARL5B	hsa-miR-4447	91.7101	NM_178815
ARL5B	hsa-miR-432-5p	91.3756	NM_178815
ARL5B	hsa-miR-4473	91.1584	NM_178815
ARL5B	hsa-miR-548at-5p	90.7157	NM_178815
ARL5B	hsa-miR-4652-3p	90.4755	NM_178815
ARL5B	hsa-miR-8075	89.884	NM_178815
ARL5B	hsa-miR-3658	89.6959	NM_178815
ARL5B	hsa-miR-181b-3p	89.5016	NM_178815
ARL5B	hsa-miR-181b-2-3p	89.5016	NM_178815
ARL5B	hsa-miR-520d-5p	89.2796	NM_178815
ARL5B	hsa-miR-524-5p	89.2796	NM_178815
ARL5B	hsa-miR-4472	89.0471	NM_178815
ARL5B	hsa-miR-4744	88.7287	NM_178815
ARL5B	hsa-miR-5010-5p	88.4336	NM_178815
ARL5B	hsa-miR-4525	88.4336	NM_178815
ARL5B	hsa-miR-4699-5p	87.9869	NM_178815
ARL5B	hsa-miR-3671	87.2248	NM_178815
ARL5B	hsa-miR-26a-5p	87.0727	NM_178815
ARL5B	hsa-miR-26b-5p	87.0727	NM_178815
ARL5B	hsa-miR-6507-5p	86.9941	NM_178815
ARL5B	hsa-miR-4420	86.4795	NM_178815
ARL5B	hsa-miR-28-3p	86.3787	NM_178815
ARL5B	hsa-miR-4693-5p	85.7806	NM_178815
ARL5B	hsa-miR-6131	85.5536	NM_178815
ARL5B	hsa-miR-506-3p	85.0334	NM_178815
ARL5B	hsa-miR-124-3p	85.0334	NM_178815
ARL5B	hsa-miR-4760-5p	84.6454	NM_178815
ARL5B	hsa-miR-570-3p	83.6284	NM_178815
ARL5B	hsa-miR-8061	83.4374	NM_178815
ARL5B	hsa-miR-548p	83.2721	NM_178815
ARL5B	hsa-miR-548an	83.0489	NM_178815
ARL5B	hsa-miR-4511	83.0003	NM_178815
ARL5B	hsa-miR-6505-3p	82.9761	NM_178815
ARL5B	hsa-miR-3923	82.7949	NM_178815
ARL5B	hsa-miR-4790-3p	82.793	NM_178815
ARL5B	hsa-miR-4999-5p	82.4774	NM_178815
ARL5B	hsa-miR-4465	81.7118	NM_178815
ARL5B	hsa-miR-5581-3p	80.6188	NM_178815
ARL5B	hsa-miR-625-5p	80.2632	NM_178815
ARL5B	hsa-miR-145-5p	80.2316	NM_178815

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Motifs and transcription factors (TFs) regulating ARL5B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARL5B	transfac_pro__M07270	TEAD4 (directAnnotation).
ARL5B	taipale_tf_pairs__FOXJ3_ELF1_NNARAAAACCGAAWMN_CAP	ELF1; FOXJ3 (directAnnotation).
ARL5B	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ARL5B	transfac_pro__M06404	ZNF497 (directAnnotation).
ARL5B	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
ARL5B	taipale_tf_pairs__FOXJ2_ELF1_RMAGAAAACCGAANN_CAP_repr	ELF1; FOXJ2 (directAnnotation).
ARL5B	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
ARL5B	cisbp__M02748	NFATC1 (directAnnotation).
ARL5B	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGNNNNNNYMATTA_CAP	ETV2; HOXA2 (directAnnotation).
ARL5B	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
ARL5B	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
ARL5B	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
ARL5B	metacluster_117.5	ZFP41 (directAnnotation). GATA5; ZFP41 (inferredBy_Orthology).
ARL5B	transfac_pro__M06661	ZNF426 (directAnnotation).
ARL5B	taipale_tf_pairs__FOXO1_ELF1_NNGAAAACCGAANM_CAP	ELF1; FOXO1 (directAnnotation).
ARL5B	hdpi__FLI1	FLI1 (directAnnotation).
ARL5B	transfac_pro__M05419	ZBTB45 (directAnnotation).
ARL5B	transfac_pro__M05935	ZNF382 (directAnnotation).
ARL5B	transfac_pro__M06165	ZNF570 (inferredBy_Orthology).
ARL5B	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
ARL5B	transfac_pro__M05884	ZNF439 (directAnnotation).
ARL5B	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ARL5B	jaspar__MA1650.1	ZBTB14 (directAnnotation).
ARL5B	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ARL5B	tfdimers__MD00364	WT1 (directAnnotation).
ARL5B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARL5B	transfac_public__M00114	CREB1 (directAnnotation).
ARL5B	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ARL5B	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
ARL5B	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
ARL5B	tfdimers__MD00297	POU5F1; ZEB1 (directAnnotation).
ARL5B	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
ARL5B	metacluster_111.5	E4F1; E4F1 (directAnnotation).
ARL5B	transfac_pro__M01239	RELA (directAnnotation).
ARL5B	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
ARL5B	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ARL5B	"Guanosine-5'-Diphosphate"	DB04315	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."