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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARL15

Summary for ARL15

Gene information	Gene symbol	ARL15
	Ensembl ID	ENSG00000185305
	Entrez ID	54622
	Gene name	ADP ribosylation factor like GTPase 15
	Synonyms	ARFRP2\|FLJ20051
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ARL15

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.70724	6.34e-06

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Expression of ARL15 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARL15

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARL15

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARL15	hsa-miR-4729	97.9911	NM_019087
ARL15	hsa-miR-6833-3p	97.6587	NM_019087
ARL15	hsa-miR-4768-5p	97.5796	NM_019087
ARL15	hsa-miR-6873-3p	94.8637	NM_019087
ARL15	hsa-miR-3919	94.6212	NM_019087
ARL15	hsa-miR-4797-3p	94.6164	NM_019087
ARL15	hsa-miR-4700-3p	93.2444	NM_019087
ARL15	hsa-miR-5696	93.0876	NM_019087
ARL15	hsa-miR-3166	92.8893	NM_019087
ARL15	hsa-miR-6074	92.4627	NM_019087
ARL15	hsa-miR-4460	92.3376	NM_019087
ARL15	hsa-miR-4749-5p	92.159	NM_019087
ARL15	hsa-miR-4499	91.6691	NM_019087
ARL15	hsa-miR-335-3p	91.1963	NM_019087
ARL15	hsa-miR-12127	91.1833	NM_019087
ARL15	hsa-miR-6718-5p	91.0598	NM_019087
ARL15	hsa-miR-203b-5p	91.0598	NM_019087
ARL15	hsa-miR-577	90.9644	NM_019087
ARL15	hsa-miR-4436a	90.5004	NM_019087
ARL15	hsa-miR-5000-3p	90.5004	NM_019087
ARL15	hsa-miR-4706	89.761	NM_019087
ARL15	hsa-miR-4694-3p	89.2473	NM_019087
ARL15	hsa-miR-4786-3p	88.4529	NM_019087
ARL15	hsa-miR-5692c	88.4479	NM_019087
ARL15	hsa-miR-5692b	88.4479	NM_019087
ARL15	hsa-miR-3163	88.1206	NM_019087
ARL15	hsa-miR-606	87.0608	NM_019087
ARL15	hsa-miR-376a-3p	86.794	NM_019087
ARL15	hsa-miR-376b-3p	86.794	NM_019087
ARL15	hsa-miR-4670-3p	86.4908	NM_019087
ARL15	hsa-miR-7110-3p	86.4473	NM_019087
ARL15	hsa-miR-4727-3p	86.4118	NM_019087
ARL15	hsa-miR-497-3p	86.3219	NM_019087
ARL15	hsa-miR-3922-5p	86.0341	NM_019087
ARL15	hsa-miR-3688-3p	85.7889	NM_019087
ARL15	hsa-miR-452-3p	85.3017	NM_019087
ARL15	hsa-miR-3662	85.1958	NM_019087
ARL15	hsa-miR-3148	85.1413	NM_019087
ARL15	hsa-miR-648	84.646	NM_019087
ARL15	hsa-miR-588	83.951	NM_019087
ARL15	hsa-miR-4701-5p	83.951	NM_019087
ARL15	hsa-miR-5197-3p	83.8335	NM_019087
ARL15	hsa-miR-338-5p	83.4994	NM_019087
ARL15	hsa-miR-3121-3p	83.3572	NM_019087
ARL15	hsa-miR-6892-5p	83.3268	NM_019087
ARL15	hsa-miR-378a-5p	81.5329	NM_019087
ARL15	hsa-miR-1200	81.5329	NM_019087
ARL15	hsa-miR-199a-3p	80.8259	NM_019087
ARL15	hsa-miR-199b-3p	80.8259	NM_019087
ARL15	hsa-miR-3129-5p	80.8259	NM_019087

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Motifs and transcription factors (TFs) regulating ARL15

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARL15	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ARL15	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ARL15	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."