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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARL13B

Summary for ARL13B

Gene information	Gene symbol	ARL13B
	Ensembl ID	ENSG00000169379
	Entrez ID	200894
	Gene name	ADP ribosylation factor like GTPase 13B
	Synonyms	ARL2L1\|DKFZp761H079\|JBTS8
	Gene type	protein_coding
	UniProtAcc	Q3SXY8

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Dataset with differentially expressed gene: ARL13B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.587274	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.521392	0.00e+00

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Expression of ARL13B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARL13B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARL13B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARL13B	hsa-miR-4775	99.3032	NM_182896
ARL13B	hsa-miR-4282	99.0321	NM_001321328
ARL13B	hsa-miR-3163	98.6447	NM_001174150
ARL13B	hsa-miR-6516-3p	97.8446	NM_182896
ARL13B	hsa-miR-656-3p	97.0436	NM_001321328
ARL13B	hsa-miR-524-5p	96.758	NM_001174150
ARL13B	hsa-miR-520d-5p	96.758	NM_001174150
ARL13B	hsa-miR-6818-5p	96.5299	NM_182896
ARL13B	hsa-miR-153-5p	95.8138	NM_001321328
ARL13B	hsa-miR-3658	94.9629	NM_001321328
ARL13B	hsa-miR-96-3p	94.6521	NM_182896
ARL13B	hsa-miR-10393-5p	94.2982	NM_182896
ARL13B	hsa-miR-607	93.7315	NM_001321328
ARL13B	hsa-miR-548l	93.6121	NM_182896
ARL13B	hsa-miR-6507-5p	92.7381	NM_001321328
ARL13B	hsa-miR-559	92.5362	NM_001321328
ARL13B	hsa-miR-133b	92.3458	NM_001174150
ARL13B	hsa-miR-133a-3p	92.3458	NM_001174150
ARL13B	hsa-miR-944	91.9815	NM_001321328
ARL13B	hsa-miR-548n	91.9245	NM_001321328
ARL13B	hsa-miR-4659b-3p	91.629	NM_001174150
ARL13B	hsa-miR-4659a-3p	91.629	NM_001174150
ARL13B	hsa-miR-548as-5p	91.579	NM_001321328
ARL13B	hsa-miR-548a-5p	91.579	NM_001321328
ARL13B	hsa-miR-548j-5p	91.579	NM_001321328
ARL13B	hsa-miR-548o-5p	91.579	NM_001321328
ARL13B	hsa-miR-548y	91.579	NM_001321328
ARL13B	hsa-miR-548c-5p	91.579	NM_001321328
ARL13B	hsa-miR-548w	91.579	NM_001321328
ARL13B	hsa-miR-548ak	91.579	NM_001321328
ARL13B	hsa-miR-548ab	91.579	NM_001321328
ARL13B	hsa-miR-548bb-5p	91.579	NM_001321328
ARL13B	hsa-miR-548au-5p	91.579	NM_001321328
ARL13B	hsa-miR-548i	91.579	NM_001321328
ARL13B	hsa-miR-548ae-5p	91.579	NM_001321328
ARL13B	hsa-miR-548ay-5p	91.579	NM_001321328
ARL13B	hsa-miR-548ad-5p	91.579	NM_001321328
ARL13B	hsa-miR-548ar-5p	91.579	NM_001321328
ARL13B	hsa-miR-548h-5p	91.579	NM_001321328
ARL13B	hsa-miR-548ap-5p	91.579	NM_001321328
ARL13B	hsa-miR-548d-5p	91.579	NM_001321328
ARL13B	hsa-miR-548b-5p	91.579	NM_001321328
ARL13B	hsa-miR-548am-5p	91.579	NM_001321328
ARL13B	hsa-miR-548aq-5p	91.5105	NM_001321328
ARL13B	hsa-miR-8063	91.2016	NM_001321328
ARL13B	hsa-miR-4729	90.7789	NM_182896
ARL13B	hsa-miR-4668-3p	90.6378	NM_182896
ARL13B	hsa-miR-548c-3p	90.4127	NM_001321328
ARL13B	hsa-miR-586	90.3536	NM_182896
ARL13B	hsa-miR-372-5p	90.0455	NM_001321328

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Motifs and transcription factors (TFs) regulating ARL13B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARL13B	metacluster_135.11	NR2C2 (directAnnotation).
ARL13B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARL13B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARL13B	metacluster_198.3	ZFP64 (directAnnotation).
ARL13B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARL13B	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARL13B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARL13B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ARL13B	hdpi__TP73	TP73 (directAnnotation).
ARL13B	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ARL13B	cisbp__M02645	ETS1 (directAnnotation).
ARL13B	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ARL13B	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
ARL13B	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ARL13B	transfac_pro__M04862	NRF1 (directAnnotation).
ARL13B	jaspar__MA0748.2	YY2 (directAnnotation).
ARL13B	transfac_pro__M01298	MECP2 (directAnnotation).
ARL13B	metacluster_182.10	ZFX (directAnnotation).
ARL13B	transfac_pro__M00492	STAT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."