Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: ARID3A

Summary for ARID3A

Gene information	Gene symbol	ARID3A
	Ensembl ID	ENSG00000116017
	Entrez ID	1820
	Gene name	AT-rich interaction domain 3A
	Synonyms	BRIGHT\|DRIL1
	Gene type	protein_coding
	UniProtAcc	Q99856

Top

Dataset with differentially expressed gene: ARID3A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.266546	1.35e-07
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	B cells	-0.411687	1.53e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.287962	0.00e+00

Top

Expression of ARID3A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ARID3A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ARID3A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARID3A	hsa-miR-5011-5p	100	NM_005224
ARID3A	hsa-miR-190a-3p	100	NM_005224
ARID3A	hsa-miR-4753-3p	97.0271	NM_005224
ARID3A	hsa-miR-627-3p	87.7709	NM_005224
ARID3A	hsa-miR-4500	87.246	NM_005224
ARID3A	hsa-miR-6885-3p	86.8082	NM_005224
ARID3A	hsa-miR-3163	86.1293	NM_005224
ARID3A	hsa-miR-670-5p	86.0368	NM_005224
ARID3A	hsa-miR-345-3p	85.8327	NM_005224
ARID3A	hsa-miR-9983-3p	84.839	NM_005224
ARID3A	hsa-miR-6817-3p	83.9528	NM_005224
ARID3A	hsa-let-7b-5p	83.9009	NM_005224
ARID3A	hsa-let-7a-5p	83.9009	NM_005224
ARID3A	hsa-miR-98-5p	83.9009	NM_005224
ARID3A	hsa-let-7g-5p	83.9009	NM_005224
ARID3A	hsa-let-7c-5p	83.9009	NM_005224
ARID3A	hsa-let-7e-5p	83.9009	NM_005224
ARID3A	hsa-let-7i-5p	83.9009	NM_005224
ARID3A	hsa-let-7f-5p	83.9009	NM_005224
ARID3A	hsa-miR-3166	83.1918	NM_005224
ARID3A	hsa-miR-3919	82.4544	NM_005224
ARID3A	hsa-miR-3121-3p	82.1147	NM_005224
ARID3A	hsa-miR-130b-5p	81.6169	NM_005224

Page: 1

Top

Motifs and transcription factors (TFs) regulating ARID3A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARID3A	transfac_pro__M04761	HSF1 (directAnnotation).
ARID3A	jaspar__MA1125.1	ZNF384 (directAnnotation).
ARID3A	taipale_tf_pairs__PBX4_HOXA10_CCATAAATCA_CAP	HOXA10; PBX4 (directAnnotation).
ARID3A	taipale_tf_pairs__ERF_SREBF2_NNCACGTGACMGGAARNN_CAP_repr	ERF; SREBF2 (directAnnotation).
ARID3A	hocomoco__CPEB1_HUMAN.H11MO.0.D	CPEB1 (directAnnotation).
ARID3A	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
ARID3A	metacluster_46.5	HLF; TEF (directAnnotation).
ARID3A	transfac_pro__M01297	HOXA13 (directAnnotation).
ARID3A	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
ARID3A	metacluster_9.49	POU3F4 (inferredBy_Orthology).
ARID3A	tfdimers__MD00006	FOXA1; FOXA2; FOXA3; NR3C1; PGR (directAnnotation).
ARID3A	metacluster_47.1	E4F1; SPDEF; SPDEF (directAnnotation).
ARID3A	taipale_tf_pairs__MEIS1_DRGX_TGACASTAATKR_CAP_repr	DRGX; MEIS1 (directAnnotation).
ARID3A	transfac_pro__M06995	NFE2L3 (directAnnotation).
ARID3A	cisbp__M01815	CEBPE (inferredBy_Orthology).
ARID3A	transfac_pro__M06521	ZFP62 (directAnnotation).
ARID3A	tfdimers__MD00472	EP300; HOXA13 (directAnnotation).
ARID3A	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
ARID3A	metacluster_178.10	POU2F2; POU4F1; POU4F1; POU4F2; POU4F2; POU4F3; POU4F3 (directAnnotation). CCDC160; HDX; POU1F1; POU2F1; POU2F2; POU3F1; POU3F2; POU3F3; POU3F4; POU4F1; POU4F2; POU4F3; POU5F1; POU5F1B; POU5F2; POU6F1; POU6F2 (inferredBy_Orthology).
ARID3A	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
ARID3A	tfdimers__MD00423	ARID3A; PAX4 (directAnnotation).
ARID3A	kznf__ZKSCAN2_Imbeault2017_OM_RCADE	ZKSCAN2 (directAnnotation).
ARID3A	tfdimers__MD00285	PDX1; SMAD1 (directAnnotation).
ARID3A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARID3A	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
ARID3A	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ARID3A	transfac_pro__M01973	PLAG1 (directAnnotation).
ARID3A	tfdimers__MD00391	KLF4 (directAnnotation).
ARID3A	tfdimers__MD00151	CHURC1 (directAnnotation).
ARID3A	cisbp__M00139	ZNF281 (inferredBy_Orthology).
ARID3A	transfac_public__M00491	PATZ1 (directAnnotation).
ARID3A	transfac_pro__M01122	ZNF219 (directAnnotation).
ARID3A	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ARID3A	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ARID3A	transfac_pro__M00986	CHURC1 (directAnnotation).
ARID3A	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
ARID3A	cisbp__M00249	WT1 (directAnnotation).
ARID3A	transfac_pro__M01714	KLF15 (directAnnotation).
ARID3A	cisbp__M00135	ZBTB7B (inferredBy_Orthology).
ARID3A	swissregulon__hs__PATZ1	PATZ1 (directAnnotation).
ARID3A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ARID3A	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
ARID3A	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
ARID3A	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
ARID3A	transfac_pro__M01303	SP1 (directAnnotation).
ARID3A	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
ARID3A	transfac_pro__M07397	ZNF148 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
ARID3A	tfdimers__MD00423	down	B cells	GSE161801_PI	post
ARID3A	metacluster_159.3	up	Mono/Macro	GSE164551	NA

Page: 1

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."