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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARHGEF12

Summary for ARHGEF12

Gene information	Gene symbol	ARHGEF12
	Ensembl ID	ENSG00000196914
	Entrez ID	23365
	Gene name	Rho guanine nucleotide exchange factor 12
	Synonyms	KIAA0382\|LARG
	Gene type	protein_coding
	UniProtAcc	Q9NZN5

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Dataset with differentially expressed gene: ARHGEF12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.832248	1.34e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.360925	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.258754	2.90e-23
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.352755	2.69e-08
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.672092	0.00e+00

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Expression of ARHGEF12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARHGEF12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARHGEF12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARHGEF12	hsa-miR-548c-3p	98.6601	NM_001198665
ARHGEF12	hsa-miR-5011-5p	98.4186	NM_001198665
ARHGEF12	hsa-miR-190a-3p	98.2502	NM_001198665
ARHGEF12	hsa-miR-4698	94.9716	NM_001198665
ARHGEF12	hsa-miR-5187-3p	94.207	NM_001198665
ARHGEF12	hsa-miR-4282	93.7428	NM_001198665
ARHGEF12	hsa-miR-9851-3p	93.3191	NM_001198665
ARHGEF12	hsa-miR-545-5p	92.549	NM_001198665
ARHGEF12	hsa-miR-508-3p	91.9613	NM_001198665
ARHGEF12	hsa-miR-593-5p	91.6191	NM_001198665
ARHGEF12	hsa-miR-6073	91.1258	NM_001198665
ARHGEF12	hsa-miR-3148	90.9618	NM_001198665
ARHGEF12	hsa-miR-659-3p	90.3281	NM_001198665
ARHGEF12	hsa-miR-607	89.9881	NM_001198665
ARHGEF12	hsa-miR-193a-3p	89.9591	NM_001198665
ARHGEF12	hsa-miR-193b-3p	89.9591	NM_001198665
ARHGEF12	hsa-miR-148a-3p	89.7124	NM_001198665
ARHGEF12	hsa-miR-148b-3p	89.7124	NM_001198665
ARHGEF12	hsa-miR-152-3p	89.7124	NM_001198665
ARHGEF12	hsa-miR-1276	89.1813	NM_001198665
ARHGEF12	hsa-miR-1284	89.0154	NM_001198665
ARHGEF12	hsa-miR-4477a	88.338	NM_001198665
ARHGEF12	hsa-miR-3180-5p	88.2523	NM_001198665
ARHGEF12	hsa-miR-4303	87.6902	NM_001198665
ARHGEF12	hsa-miR-570-3p	87.4029	NM_001198665
ARHGEF12	hsa-miR-4652-3p	86.6443	NM_001198665
ARHGEF12	hsa-miR-96-5p	86.5381	NM_001198665
ARHGEF12	hsa-miR-7-2-3p	86.0773	NM_001198665
ARHGEF12	hsa-miR-7-1-3p	86.0773	NM_001198665
ARHGEF12	hsa-miR-146a-3p	85.753	NM_001198665
ARHGEF12	hsa-miR-488-5p	85.4603	NM_001198665
ARHGEF12	hsa-miR-3919	85.4354	NM_001198665
ARHGEF12	hsa-miR-4782-5p	85.3814	NM_001198665
ARHGEF12	hsa-miR-5706	85.3814	NM_001198665
ARHGEF12	hsa-miR-12133	85.0715	NM_001198665
ARHGEF12	hsa-miR-1271-5p	85.0715	NM_001198665
ARHGEF12	hsa-miR-4760-3p	84.5268	NM_001198665
ARHGEF12	hsa-miR-4291	84.0297	NM_001198665
ARHGEF12	hsa-miR-3671	83.7268	NM_001198665
ARHGEF12	hsa-miR-3176	83.2628	NM_001198665
ARHGEF12	hsa-miR-3922-3p	83.2628	NM_001198665
ARHGEF12	hsa-miR-5002-5p	82.9089	NM_001198665
ARHGEF12	hsa-miR-525-5p	82.8276	NM_001198665
ARHGEF12	hsa-miR-520a-5p	82.8276	NM_001198665
ARHGEF12	hsa-miR-4793-5p	82.575	NM_001198665
ARHGEF12	hsa-miR-9902	82.5633	NM_001198665
ARHGEF12	hsa-miR-4522	82.4099	NM_001198665
ARHGEF12	hsa-miR-4789-5p	82.2456	NM_001198665
ARHGEF12	hsa-miR-3926	82.1792	NM_001198665
ARHGEF12	hsa-miR-6765-3p	81.7858	NM_001198665

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Motifs and transcription factors (TFs) regulating ARHGEF12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARHGEF12	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ARHGEF12	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
ARHGEF12	metacluster_52.11	ZNF184 (directAnnotation).
ARHGEF12	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ARHGEF12	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ARHGEF12	transfac_pro__M00716	ZBTB14 (directAnnotation).
ARHGEF12	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ARHGEF12	transfac_pro__M04893	TAF1 (directAnnotation).
ARHGEF12	transfac_pro__M03876	ZBTB33 (directAnnotation).
ARHGEF12	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ARHGEF12	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARHGEF12	metacluster_135.11	NR2C2 (directAnnotation).
ARHGEF12	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARHGEF12	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARHGEF12	metacluster_7.13	ZFX (directAnnotation).
ARHGEF12	cisbp__M00968	MTF2 (directAnnotation).
ARHGEF12	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARHGEF12	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARHGEF12	cisbp__M00341	PAX6 (directAnnotation).
ARHGEF12	metacluster_198.3	ZFP64 (directAnnotation).
ARHGEF12	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ARHGEF12	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARHGEF12	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARHGEF12	cisbp__M00788	ZFY (inferredBy_Orthology).
ARHGEF12	hdpi__ZNF304	ZNF304 (directAnnotation).
ARHGEF12	transfac_pro__M01199	TRIM28 (directAnnotation).
ARHGEF12	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARHGEF12	transfac_pro__M03806	ZBTB7C (directAnnotation).
ARHGEF12	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARHGEF12	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
ARHGEF12	transfac_pro__M01968	FOXO1 (directAnnotation).
ARHGEF12	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
ARHGEF12	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ARHGEF12	jaspar__MA1122.1	TFDP1 (directAnnotation).
ARHGEF12	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ARHGEF12	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
ARHGEF12	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."