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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARHGAP5

Summary for ARHGAP5

Gene information	Gene symbol	ARHGAP5
	Ensembl ID	ENSG00000100852
	Entrez ID	394
	Gene name	Rho GTPase activating protein 5
	Synonyms	GFI2\|p190-B\|p190BRhoGAP\|RhoGAP5
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ARHGAP5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.638763	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.895404	0.00e+00

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Expression of ARHGAP5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARHGAP5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARHGAP5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARHGAP5	hsa-miR-590-3p	99.8294	NM_001030055
ARHGAP5	hsa-miR-4775	99.7002	NM_001030055
ARHGAP5	hsa-miR-494-3p	99.4604	NM_001030055
ARHGAP5	hsa-miR-3163	98.7731	NM_001030055
ARHGAP5	hsa-miR-3148	97.904	NM_001030055
ARHGAP5	hsa-miR-549a-3p	95.2914	NM_001030055
ARHGAP5	hsa-miR-7-1-3p	94.9395	NM_001030055
ARHGAP5	hsa-miR-7-2-3p	94.9395	NM_001030055
ARHGAP5	hsa-miR-376a-5p	94.9366	NM_001030055
ARHGAP5	hsa-miR-3908	94.7488	NM_001030055
ARHGAP5	hsa-miR-5688	94.4438	NM_001030055
ARHGAP5	hsa-miR-224-3p	94.3385	NM_001030055
ARHGAP5	hsa-miR-522-3p	94.3385	NM_001030055
ARHGAP5	hsa-miR-548c-3p	94.3067	NM_001030055
ARHGAP5	hsa-miR-8066	94.1043	NM_001030055
ARHGAP5	hsa-miR-4760-5p	94.0291	NM_001030055
ARHGAP5	hsa-miR-486-5p	93.7568	NM_001030055
ARHGAP5	hsa-miR-8061	93.6613	NM_001030055
ARHGAP5	hsa-miR-551b-5p	93.4433	NM_001030055
ARHGAP5	hsa-miR-1251-3p	93.3324	NM_001030055
ARHGAP5	hsa-miR-5585-3p	93.1125	NM_001030055
ARHGAP5	hsa-miR-9-3p	93.04	NM_001030055
ARHGAP5	hsa-miR-7152-5p	92.9242	NM_001030055
ARHGAP5	hsa-miR-137-3p	92.7802	NM_001030055
ARHGAP5	hsa-miR-495-3p	92.7215	NM_001030055
ARHGAP5	hsa-miR-4699-3p	92.4215	NM_001030055
ARHGAP5	hsa-miR-1277-5p	92.2642	NM_001030055
ARHGAP5	hsa-miR-369-3p	92.0494	NM_001030055
ARHGAP5	hsa-miR-576-5p	91.6123	NM_001030055
ARHGAP5	hsa-miR-548at-5p	91.426	NM_001030055
ARHGAP5	hsa-miR-186-5p	90.8222	NM_001030055
ARHGAP5	hsa-miR-3121-3p	90.4632	NM_001030055
ARHGAP5	hsa-miR-3613-3p	90.4469	NM_001030055
ARHGAP5	hsa-miR-3529-3p	90.3625	NM_001030055
ARHGAP5	hsa-miR-377-3p	90.2692	NM_001030055
ARHGAP5	hsa-miR-1252-3p	90.1332	NM_001030055
ARHGAP5	hsa-miR-144-3p	89.7133	NM_001030055
ARHGAP5	hsa-miR-5692c	89.6797	NM_001030055
ARHGAP5	hsa-miR-5692b	89.6797	NM_001030055
ARHGAP5	hsa-miR-513b-5p	89.1082	NM_001030055
ARHGAP5	hsa-miR-4668-5p	89.0726	NM_001030055
ARHGAP5	hsa-miR-4282	88.9281	NM_001030055
ARHGAP5	hsa-miR-8063	88.8391	NM_001030055
ARHGAP5	hsa-miR-642b-5p	88.2758	NM_001030055
ARHGAP5	hsa-miR-7161-3p	88.1445	NM_001030055
ARHGAP5	hsa-miR-186-3p	88.1249	NM_001030055
ARHGAP5	hsa-miR-371b-5p	87.6557	NM_001030055
ARHGAP5	hsa-miR-373-5p	87.6557	NM_001030055
ARHGAP5	hsa-miR-616-5p	87.6557	NM_001030055
ARHGAP5	hsa-miR-603	87.6218	NM_001030055

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Motifs and transcription factors (TFs) regulating ARHGAP5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARHGAP5	jaspar__MA1933.1	SREBF2 (directAnnotation).
ARHGAP5	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ARHGAP5	metacluster_52.11	ZNF184 (directAnnotation).
ARHGAP5	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
ARHGAP5	metacluster_35.7	HINFP (inferredBy_Orthology).
ARHGAP5	metacluster_135.11	NR2C2 (directAnnotation).
ARHGAP5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARHGAP5	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARHGAP5	metacluster_7.13	ZFX (directAnnotation).
ARHGAP5	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ARHGAP5	cisbp__M00968	MTF2 (directAnnotation).
ARHGAP5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARHGAP5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARHGAP5	cisbp__M00341	PAX6 (directAnnotation).
ARHGAP5	metacluster_198.3	ZFP64 (directAnnotation).
ARHGAP5	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARHGAP5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ARHGAP5	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARHGAP5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARHGAP5	cisbp__M00788	ZFY (inferredBy_Orthology).
ARHGAP5	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ARHGAP5	metacluster_175.1	ZNF283 (directAnnotation).
ARHGAP5	hdpi__ZNF304	ZNF304 (directAnnotation).
ARHGAP5	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ARHGAP5	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ARHGAP5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARHGAP5	transfac_pro__M01199	TRIM28 (directAnnotation).
ARHGAP5	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ARHGAP5	metacluster_151.2	ZNF23 (directAnnotation).
ARHGAP5	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARHGAP5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARHGAP5	transfac_pro__M03806	ZBTB7C (directAnnotation).
ARHGAP5	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."